Ribosomal RNA small subunit methyltransferase C (P39406)

Identification
Name:Ribosomal RNA small subunit methyltransferase C
Synonyms:
  • 16S rRNA m2G1207 methyltransferase
  • rRNA (guanine-N(2)-)-methyltransferase rsmC
Gene Name:rsmC
Enzyme Class:
Biological Properties
General Function:Involved in nucleic acid binding
Specific Function:Specifically methylates the guanosine in position 1207 of 16S rRNA in the 30S particle
Cellular Location:Cytoplasm (Potential)
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
KEGG Reactions:
1.0Thumb+1.0rRNA ↔ 1.0Thumb+1.0rRNA containing N2-methylguanine
1.0S-Adenosylmethionine + 1.0rRNA ↔ 1.0S-Adenosylhomocysteine + 1.0rRNA containing N2-methylguanine
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00939S-AdenosylhomocysteineMetaboCard
ECMDB01185S-AdenosylmethionineMetaboCard
GO Classification:
Function
binding
catalytic activity
methyltransferase activity
N-methyltransferase activity
nucleic acid binding
rRNA (guanine-N2-)-methyltransferase activity
transferase activity
transferase activity, transferring one-carbon groups
Process
cellular macromolecule metabolic process
cellular metabolic process
macromolecule metabolic process
metabolic process
methylation
ncRNA metabolic process
one-carbon metabolic process
RNA metabolic process
rRNA metabolic process
rRNA processing
Gene Properties
Blattner:b4371
Gene OrientationCounterclockwise
Centisome Percentage:99.25
Left Sequence End4604692
Right Sequence End4605723
Gene Sequence:
>1032 bp
ATGGCGACCATAAAGGATGTAGCCCGACTGGCAGGCGTTTCAGTCGCCACCGTTTCCCGC
GTCATTAATAATTCACCCAAAGCCAGCGAAGCTTCCCGGCTGGCTGTGCATAGTGCAATG
GAGTCTCTTAGCTATCACCCGAACGCCAACGCCCGTGCGCTGGCGCAGCAGACCACTGAA
ACGGTCGGTCTGGTCGTTGGTGATGTTTCCGATCCGTTTTTCGGTGCAATGGTGAAAGCG
GTCGAACAGGTGGCTTATCACACCGGTAATTTTTTATTGATTGGCAACGGTTACCACAAC
GAACAAAAAGAGCGTCAGGCCATTGAGCAACTGATCCGCCATCGCTGTGCTGCGTTGGTC
GTCCATGCCAAAATGATCCCGGATGCTGATTTAGCCTCATTAATGAAACAAATGCCCGGT
ATGGTGCTGATCAACCGTATCCTGCCTGGCTTTGAAAACCGTTGTATTGCTCTGGACGAT
CGTTACGGTGCCTGGCTGGCAACGCGTCATTTAATTCAGCAAGGTCATACCCGCATTGGT
TATCTGTGCTCTAACCACTCTATTTCTGACGCCGAAGATCGTCTGCAAGGGTATTACGAT
GCCCTTGCTGAAAGTGGTATTGCGGCCAATGACCGGCTGGTGACATTTGGCGAACCAGAC
GAAAGCGGCGGCGAACAGGCAATGACCGAGCTTTTGGGACGAGGAAGAAATTTCACTGCG
GTAGCCTGTTATAACGATTCAATGGCGGCGGGTGCGATGGGCGTTCTCAATGATAATGGT
ATTGATGTACCGGGTGAGATTTCGTTAATTGGCTTTGATGATGTGCTGGTGTCACGCTAT
GTGCGTCCGCGCCTGACCACCGTGCGTTACCCAATCGTGACGATGGCGACCCAGGCTGCC
GAACTGGCTTTGGCGCTGGCGGATAATCGCCCTCTCCCGGAAATCACTAATGTCTTTAGT
CCGACGCTGGTACGTCGTCATTCAGTGTCAACTCCGTCGCTGGAGGCAAGTCATCATGCA
ACCAGCGACTAA
Protein Properties
Pfam Domain Function:
Protein Residues:343
Protein Molecular Weight:37624
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Ribosomal RNA small subunit methyltransferase C
MSAFTPASEVLLRHSDDFEQSRILFAGDLQDDLPARLDTAASRAHTQQFHHWQVLSRQMG
DNARFSLVATADDVADCDTLIYYWPKNKPEAQFQLMNLLSLLPVGTDIFVVGENRSGVRS
AEQMLADYAPLNKVDSARRCGLYFGRLEKQPVFDAEKFWGEYSVDGLTVKTLPGVFSRDG
LDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSVAFARHSPKIRLTLCDVSAPAVEASRATL
AANGVEGEVFASNVFSEVKGRFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELR
IVANAFLPYPDVLDETFGFHEVIAQTGRFKVYRAIMTRQAKKG
References
External Links:
ResourceLink
Uniprot ID:P39406
Uniprot Name:RSMC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85675653
Ecogene ID:EG12596
Ecocyc:EG12596
ColiBase:b4371
Kegg Gene:b4371
EchoBASE ID:EB2481
CCDB:RSMC_ECOLI
BacMap:16132189
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L., Blattner, F. R. (1995). "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Nucleic Acids Res 23:2105-2119. Pubmed: 7610040
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Sunita, S., Purta, E., Durawa, M., Tkaczuk, K. L., Swaathi, J., Bujnicki, J. M., Sivaraman, J. (2007). "Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC." Nucleic Acids Res 35:4264-4274. Pubmed: 17576679
  • Tscherne, J. S., Nurse, K., Popienick, P., Ofengand, J. (1999). "Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli." J Biol Chem 274:924-929. Pubmed: 9873033