ECMDB

Identification

Name:

4,5-DOPA dioxygenase extradiol

Synonyms:

Not Available

Gene Name:

ygiD

Enzyme Class:

1.13.11.29

Biological Properties

General Function:

cellular aromatic compound metabolic process

Specific Function:

In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Tyrosine metabolism ec00350

KEGG Reactions:

1.0

↔

1.0

1.03,4-Dihydroxy-L-phenylalanine + 1.0Oxygen ↔ 1.04-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
ReactionCard

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
cellular aromatic compound metabolic process
cytoplasm
ferrous iron binding
stizolobate synthase activity
zinc ion binding

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>789
atgtcttcaacacgtatgccagcattgtttttaggtcacggtagtccgatgaacgtgctg
gaagataatttgtatacccgcagctggcagaagttggggatgacattgccacgcccgcaa
gcgattgtggtggtttcggctcactggtttacccgtggaacaggagtgaccgcgatggag
acgccgcccacgattcatgactttggtggcttcccgcaggcgctgtacgatacgcattat
cctgctccgggttcgcctgcgctggcacagcgtctggttgagctgttagcgccgatcccg
gtgacgctggataaagaagcctggggctttgaccacggctcgtggggcgtgctgattaag
atgtatcctgacgctgatatcccgatggtgcagttgagtatcgacagtagcaaacctgcc
gcctggcatttcgaaatggggcgcaaactggcagcgctgcgagatgaaggaataatgttg
gtcgccagcggtaacgtggtgcataacctgcgcacagtgaagtggcacggtgatagttca
ccgtatccgtgggcgacgtcgtttaatgagtatgtgaaagcgaatctgacgtggcaaggg
ccagtggaacaacatcctctggtgaattacctcgaccatgaaggtggcacgttatcgaac
ccaacgccagagcattatttgccgttgttgtatgtgttaggtgcgtgggatgggcaggag
ccaattaccattccggttgagggtatagaaatgggcagcctgagtatgctgtcggtgcag
ataggctaa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

262

Protein Molecular Weight:

28891

Protein Theoretical pI:

Not Available

PDB File:

2PW6

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>4,5-DOPA dioxygenase extradiol
MSSTRMPALFLGHGSPMNVLEDNLYTRSWQKLGMTLPRPQAIVVVSAHWFTRGTGVTAME
TPPTIHDFGGFPQALYDTHYPAPGSPALAQRLVELLAPIPVTLDKEAWGFDHGSWGVLIK
MYPDADIPMVQLSIDSSKPAAWHFEMGRKLAALRDEGIMLVASGNVVHNLRTVKWHGDSS
PYPWATSFNEYVKANLTWQGPVEQHPLVNYLDHEGGTLSNPTPEHYLPLLYVLGAWDGQE
PITIPVEGIEMGSLSMLSVQIG

References

External Links:

Resource	Link
Uniprot ID:	P24197
Uniprot Name:	YGID_ECOLI
PDB ID:	2PW6
CCDB:	YGID_ECOLI

General Reference:

Not Available

4,5-DOPA dioxygenase extradiol (P24197)