Enterobactin exporter entS (P24077)

Identification
Name:Enterobactin exporter entS
Synonyms:
  • Protein p43
Gene Name:entS
Enzyme Class:Not Available
Biological Properties
General Function:Involved in siderophore transport
Specific Function:Exports the siderophore enterobactin out of the cell
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
  • Biosynthesis of siderophore group nonribosomal peptides PW000760
  • inner membrane transport PW000786
KEGG Pathways:
  • Biosynthesis of siderophore group nonribosomal peptides ec01053
Transports:
Transport References:
  • Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
Metabolites:
ECMDB IDNameView
ECMDB21212EnterochelinMetaboCard
ECMDB21225Hydrogen ionMetaboCard
GO Classification:Not Available
Gene Properties
Blattner:b0591
Gene OrientationClockwise
Centisome Percentage:13.40
Left Sequence End621523
Right Sequence End622773
Gene Sequence:
>1251 bp
ATGAATAAACAATCCTGGCTGCTTAACCTCAGCCTGTTGAAAACGCACCCGGCGTTTCGC
GCAGTATTCCTCGCTCGTTTCATCTCAATTGTGTCTCTGGGTTTGCTCGGCGTCGCGGTG
CCGGTGCAGATCCAGATGATGACACATTCCACCTGGCAGGTGGGGCTTTCGGTGACGCTG
ACCGGCGGCGCGATGTTTGTTGGCCTGATGGTCGGCGGTGTGCTGGCGGATCGCTATGAG
CGCAAAAAAGTGATTTTGCTGGCGCGCGGCACCTGTGGCATTGGCTTCATTGGACTGTGC
CTTAATGCACTGCTGCCGGAGCCGTCATTGCTGGCAATCTATTTACTTGGTTTATGGGAT
GGTTTTTTCGCATCGCTTGGCGTTACGGCGCTATTGGCGGCGACACCAGCACTGGTAGGG
CGTGAAAACTTAATGCAGGCCGGGGCGATCACCATGTTGACCGTGCGTCTGGGGTCGGTG
ATTTCGCCCATGATTGGCGGTTTATTGCTGGCGACCGGTGGCGTAGCCTGGAACTACGGG
CTGGCGGCGGCGGGCACGTTTATTACCTTGCTACCGTTGTTAAGCCTTCCGGCGTTGCCA
CCGCCACCGCAGCCGCGTGAGCATCCGTTGAAATCATTACTGGCAGGATTTCGTTTTCTG
CTTGCCAGCCCGCTGGTGGGCGGGATTGCGCTGCTGGGTGGTTTATTGACGATGGCGAGC
GCGGTGCGGGTACTGTATCCGGCGCTGGCTGACAACTGGCAGATGTCAGCGGCACAGATT
GGTTTTCTCTACGCGGCGATCCCGCTCGGCGCGGCTATTGGTGCGTTAACCAGCGGGAAG
CTGGCACATAGTGCGCGACCAGGGTTATTGATGCTGCTCTCCACGCTGGGATCGTTCCTC
GCCATTGGTCTGTTTGGCCTGATGCCGATGTGGATTTTAGGCGTGGTTTGTCTGGCGCTG
TTCGGCTGGTTGAGTGCGGTCAGCTCGTTGCTGCAATACACAATGCTGCAAACGCAAACC
CCGGAAGCGATGTTAGGGCGGATTAACGGTTTGTGGACGGCGCAGAACGTGACGGGCGAT
GCCATAGGCGCGGCGCTGCTGGGTGGTTTGGGCGCGATGATGACACCGGTTGCTTCCGCA
AGCGCGAGCGGTTTTGGTTTGTTGATTATCGGCGTGTTGTTATTGCTGGTGCTGGTGGAG
TTGCGACATTTTCGCCAGACGCCGCCGCAGGTGACAGCGTCCGACAGTTAA
Protein Properties
Pfam Domain Function:
Protein Residues:416
Protein Molecular Weight:43281
Protein Theoretical pI:10
Signaling Regions:
  • None
Transmembrane Regions:
  • 22-42
  • 56-76
  • 96-116
  • 119-139
  • 157-177
  • 179-199
  • 219-239
  • 257-277
  • 301-321
  • 357-377
  • 379-399
Protein Sequence:
>Enterobactin exporter entS
MNKQSWLLNLSLLKTHPAFRAVFLARFISIVSLGLLGVAVPVQIQMMTHSTWQVGLSVTL
TGGAMFVGLMVGGVLADRYERKKVILLARGTCGIGFIGLCLNALLPEPSLLAIYLLGLWD
GFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMIGGLLLATGGVAWNYG
LAAAGTFITLLPLLSLPALPPPPQPREHPLKSLLAGFRFLLASPLVGGIALLGGLLTMAS
AVRVLYPALADNWQMSAAQIGFLYAAIPLGAAIGALTSGKLAHSARPGLLMLLSTLGSFL
AIGLFGLMPMWILGVVCLALFGWLSAVSSLLQYTMLQTQTPEAMLGRINGLWTAQNVTGD
AIGAALLGGLGAMMTPVASASASGFGLLIIGVLLLLVLVELRHFRQTPPQVTASDS
References
External Links:
ResourceLink
Uniprot ID:P24077
Uniprot Name:ENTS_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674712
Ecogene ID:EG11104
Ecocyc:EG11104
ColiBase:b0591
Kegg Gene:b0591
EchoBASE ID:EB1096
CCDB:ENTS_ECOLI
BacMap:16128574
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Chenault, S. S., Earhart, C. F. (1991). "Organization of genes encoding membrane proteins of the Escherichia coli ferrienterobactin permease." Mol Microbiol 5:1405-1413. Pubmed: 1787794
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Furrer, J. L., Sanders, D. N., Hook-Barnard, I. G., McIntosh, M. A. (2002). "Export of the siderophore enterobactin in Escherichia coli: involvement of a 43 kDa membrane exporter." Mol Microbiol 44:1225-1234. Pubmed: 12068807
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Shea, C. M., McIntosh, M. A. (1991). "Nucleotide sequence and genetic organization of the ferric enterobactin transport system: homology to other periplasmic binding protein-dependent systems in Escherichia coli." Mol Microbiol 5:1415-1428. Pubmed: 1838574