Identification
Name:Gamma-glutamyltranspeptidase
Synonyms:
  • Gamma-glutamyltranspeptidase large chain
  • Gamma-glutamyltranspeptidase small chain
Gene Name:ggt
Enzyme Class:
Biological Properties
General Function:Involved in gamma-glutamyltransferase activity
Specific Function:(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid
Cellular Location:Periplasm
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb
1.0Thumb+1.0L-Amino acid1.0Thumb+1.0(5-L-Glutamyl)-L-amino acid
1.0Glutathione + 1.0L-Amino acid ↔ 1.0Cysteinylglycine + 1.0(5-L-Glutamyl)-L-amino acid
ReactionCard
1.0(5-L-Glutamyl)-peptide+1.0Thumb1.0Peptide+1.0Thumb
1.0(5-L-Glutamyl)-peptide + 1.0Taurine ↔ 1.0Peptide + 1.05-L-Glutamyl-taurine
ReactionCard
1.0R-S-Glutathione+1.0Thumb1.0R-S-Cysteinylglycine+1.0Thumb
1.0R-S-Glutathione + 1.0Water ↔ 1.0R-S-Cysteinylglycine + 1.0L-Glutamate
ReactionCard
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb
1.0(5-L-Glutamyl)-peptide+1.0Thumb1.0Peptide+1.0Thumb
1.0(5-L-Glutamyl)-peptide + 1.0Se-Methylselenocysteine ↔ 1.0Peptide + 1.0gamma-Glutamyl-Se-methylselenocysteine
ReactionCard
1.0(5-L-Glutamyl)-peptide+1.0Amino acid1.0Peptide+1.05-L-Glutamyl amino acid
1.0(5-L-Glutamyl)-peptide + 1.0Amino acid ↔ 1.0Peptide + 1.05-L-Glutamyl amino acid
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0(5-L-Glutamyl)-peptide1.0Thumb+1.0Peptide
1.0Taurine + 1.0(5-L-Glutamyl)-peptide → 1.05-L-Glutamyl-taurine + 1.0Peptide
ReactionCard
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb
Complex Reactions:
1.0A (5-L-glutamyl)-peptide+1.0an amino acid1.0a peptide+1.0a 5-L-glutamyl amino acid
1.0A (5-L-glutamyl)-peptide + 1.0an amino acid → 1.0a peptide + 1.0a 5-L-glutamyl amino acid
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB200663-Cyano-L-alanineMetaboCard
ECMDB041955-L-Glutamyl-taurineMetaboCard
ECMDB21004beta-AminopropionitrileMetaboCard
ECMDB00078CysteinylglycineMetaboCard
ECMDB20150gamma-Glutamyl-beta-aminopropiononitrileMetaboCard
ECMDB20151gamma-Glutamyl-beta-cyanoalanineMetaboCard
ECMDB10716gamma-Glutamyl-Se-methylselenocysteineMetaboCard
ECMDB00125GlutathioneMetaboCard
ECMDB00148L-GlutamateMetaboCard
ECMDB21009Se-MethylselenocysteineMetaboCard
ECMDB00251TaurineMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
catalytic activity
gamma-glutamyltransferase activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring amino-acyl groups
Gene Properties
Blattner:b3447
Gene OrientationCounterclockwise
Centisome Percentage:77.23
Left Sequence End3583104
Right Sequence End3584846
Gene Sequence:
>1743 bp
ATGATAAAACCGACGTTTTTACGCCGGGTGGCCATTGCTGCTCTGCTCTCAGGAAGTTGT
TTTAGCGCCGCCGCCGCGCCTCCTGCGCCGCCCGTCTCGTATGGTGTGGAGGAAGATGTC
TTCCACCCGGTACGCGCGAAACAGGGAATGGTAGCGTCTGTGGACGCCACTGCCACTCAG
GTGGGGGTGGATATTCTCAAGGAGGGCGGGAATGCCGTTGATGCCGCCGTGGCGGTGGGC
TACGCGCTGGCGGTAACGCATCCGCAGGCAGGGAATCTGGGCGGTGGTGGTTTTATGTTA
ATCCGCTCGAAAAATGGCAATACCACGGCTATCGATTTCCGCGAAATGGCACCCGCCAAA
GCGACCCGCGATATGTTCCTCGATGATCAGGGCAACCCGGACAGCAAAAAATCACTCACT
TCGCATCTGGCTTCCGGCACACCGGGTACGGTAGCAGGTTTCTCGCTGGCGCTGGATAAA
TACGGCACCATGCCGCTGAACAAAGTCGTGCAGCCCGCGTTTAAACTGGCACGCGATGGT
TTTATCGTTAACGACGCGCTGGCTGACGATCTCAAAACCTACGGTAGCGAAGTGTTGCCG
AATCACGAAAACAGTAAAGCTATCTTCTGGAAAGAGGGCGAGCCGCTGAAAAAGGGCGAC
ACGCTGGTGCAGGCGAACCTGGCAAAGAGCCTGGAGATGATTGCTGAAAACGGCCCGGAC
GAATTCTATAAAGGCACGATTGCGGAACAGATCGCCCAGGAGATGCAGAAAAACGGTGGC
TTGATCACTAAAGAAGATTTAGCAGCCTATAAAGCGGTCGAACGCACTCCGATAAGCGGC
GATTATCGCGGGTATCAGGTTTACTCCATGCCACCGCCATCCTCCGGCGGGATCCATATC
GTACAAATCCTCAATATTCTGGAAAACTTCGATATGAAGAAATACGGCTTTGGCAGCGCC
GATGCGATGCAAATCATGGCAGAAGCGGAGAAATACGCCTACGCCGACCGCTCGGAATAT
CTTGGCGACCCGGATTTTGTCAAAGTACCGTGGCAGGCGCTGACCAATAAAGCCTATGCC
AAATCTATTGCCGATCAAATTGATATCAATAAAGCGAAGCCATCCAGCGAAATTCGCCCC
GGCAAGCTTGCGCCTTATGAGAGTAATCAAACTACCCATTACTCAGTGGTGGATAAAGAT
GGTAACGCGGTGGCGGTGACCTATACGCTGAACACCACCTTCGGTACGGGCATTGTCGCG
GGCGAGAGCGGTATTCTGCTTAATAACCAGATGGATGATTTCTCCGCCAAACCGGGCGTA
CCGAACGTTTACGGGCTGGTGGGCGGTGATGCCAACGCCGTCGGGCCGAACAAACGCCCG
CTGTCGTCGATGTCGCCGACCATTGTGGTGAAAGACGGTAAAACCTGGCTGGTTACCGGT
AGCCCAGGCGGTAGCCGGATCATCACTACAGTGCTGCAAATGGTGGTGAATAGCATCGAT
TATGGCTTGAACGTCGCCGAAGCGACCAATGCGCCGCGTTTCCACCATCAGTGGTTGCCG
GACGAGCTGCGTGTCGAAAAAGGGTTTAGCCCGGATACGCTCAAGCTGCTGGAAGCAAAA
GGTCAGAAAGTGGCGCTGAAAGAGGCGATGGGCAGTACACAAAGCATTATGGTTGGGCCG
GACGGTGAGTTGTACGGCGCATCCGACCCGCGCTCGGTGGATGATTTAACGGCGGGGTAC
TAA
Protein Properties
Pfam Domain Function:
Protein Residues:580
Protein Molecular Weight:61768
Protein Theoretical pI:5
Signaling Regions:
  • 1-25
Transmembrane Regions:
  • None
Protein Sequence:
>Gamma-glutamyltranspeptidase
MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQ
VGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAK
ATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDG
FIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPD
EFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHI
VQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYA
KSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIVA
GESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDYGLNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAK
GQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
References
External Links:
ResourceLink
Uniprot ID:P18956
Uniprot Name:GGT_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85676596
Ecogene ID:EG10374
Ecocyc:EG10374
ColiBase:b3447
Kegg Gene:b3447
EchoBASE ID:EB0369
CCDB:GGT_ECOLI
BacMap:16131319
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hashimoto, W., Suzuki, H., Nohara, S., Kumagai, H. (1992). "Escherichia coli gamma-glutamyltranspeptidase mutants deficient in processing to subunits." Biochem Biophys Res Commun 189:173-178. Pubmed: 1360205
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Sofia, H. J., Burland, V., Daniels, D. L., Plunkett, G. 3rd, Blattner, F. R. (1994). "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes." Nucleic Acids Res 22:2576-2586. Pubmed: 8041620
  • Suzuki, H., Kumagai, H., Echigo, T., Tochikura, T. (1989). "DNA sequence of the Escherichia coli K-12 gamma-glutamyltranspeptidase gene, ggt." J Bacteriol 171:5169-5172. Pubmed: 2570061