Lipopolysaccharide biosynthesis protein wzzE (P0AG00)

Identification
Name:Lipopolysaccharide biosynthesis protein wzzE
Synonyms:Not Available
Gene Name:wzzE
Enzyme Class:Not Available
Biological Properties
General Function:Involved in lipopolysaccharide biosynthetic process
Specific Function:Specific function unknown
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Complex Reactions:
1.0(enterobacterial common antigen)x2 undecaprenyl-diphosphate+1.0Thumb → 1.0(enterobacterial common antigen)x3 undecaprenyl-diphosphate+1.0Thumb+1.0Thumb
1.0(enterobacterial common antigen)x2 undecaprenyl-diphosphate + 1.0Undecaprenyl-diphospho N-acetylglucosamine-N-acetylmannosaminuronate-N-acetamido-4,6-dideoxy-D-galactose → 1.0(enterobacterial common antigen)x3 undecaprenyl-diphosphate + 1.0Hydrogen ion + 1.0Undecaprenyl diphosphate
ReactionCard
1.0(enterobacterial common antigen)x3 undecaprenyl-diphosphate+1.0Thumb → 1.0(enterobacterial common antigen)x4 undecaprenyl-diphosphate+1.0Thumb+1.0Thumb
1.0(enterobacterial common antigen)x3 undecaprenyl-diphosphate + 1.0Undecaprenyl-diphospho N-acetylglucosamine-N-acetylmannosaminuronate-N-acetamido-4,6-dideoxy-D-galactose → 1.0(enterobacterial common antigen)x4 undecaprenyl-diphosphate + 1.0Hydrogen ion + 1.0Undecaprenyl diphosphate
ReactionCard
2.0Thumb → 1.0(enterobacterial common antigen)x2 undecaprenyl-diphosphate+1.0Thumb+1.0Thumb
2.0Undecaprenyl-diphospho N-acetylglucosamine-N-acetylmannosaminuronate-N-acetamido-4,6-dideoxy-D-galactose → 1.0(enterobacterial common antigen)x2 undecaprenyl-diphosphate + 1.0Hydrogen ion + 1.0Undecaprenyl diphosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB21225Hydrogen ionMetaboCard
ECMDB01469Undecaprenyl diphosphateMetaboCard
ECMDB21297Undecaprenyl-diphospho N-acetylglucosamine-N-acetylmannosaminuronate-N-acetamido-4,6-dideoxy-D-galactoseMetaboCard
GO Classification:
Component
cell part
membrane
Process
lipid biosynthetic process
lipid metabolic process
lipopolysaccharide biosynthetic process
metabolic process
primary metabolic process
Gene Properties
Blattner:b3785
Gene OrientationClockwise
Centisome Percentage:85.50
Left Sequence End3967054
Right Sequence End3968100
Gene Sequence:
>1047 bp
ATGAACAGAACTGACGAACTCCGTACTGCGCGTATTGAGAGCCTGGTAACGCCCGCCGAA
CTCGCGCTACGGTATCCCGTAACGCCTGGCGTCGCCACCCATGTCACCGACTCCCGCCGC
AGAATTGAAAAAATACTGAATGGTGAAGATAAGCGACTGTTGGTCATTATTGGCCCCTGC
TCGATCCACGATCTCACCGCTGCAATGGAGTACGCCACCCGTCTGCAGTCGCTGCGCAAC
CAGTACCAGTCACGGCTGGAAATCGTAATGCGCACCTATTTTGAAAAACCACGAACTGTT
GTCGGCTGGAAAGGACTAATCTCCGATCCAGATTTAAACGGCAGCTATCGGGTAAATCAC
GGTCTGGAGCTGGCGCGCAAATTACTTTTACAGGTAAATGAGCTGGGCGTCCCAACCGCG
ACCGAGTTCCTCGATATGGTGACCGGTCAGTTTATTGCTGATTTAATCAGTTGGGGCGCG
ATTGGCGCACGTACTACCGAAAGTCAGATCCACCGCGAAATGGCTTCGGCACTCTCCTGT
CCGGTAGGTTTTAAAAATGGTACCGATGGCAATACGCGGATTGCTGTGGATGCTATCCGC
GCAGCCCGCGCCAGCCATATGTTCCTCTCGCCAGACAAAAATGGTCAGATGACCATCTAT
CAGACCAGCGGCAACCCGTATGGCCACATTATTATGCGTGGCGGCAAAAAACCGAATTAT
CATGCCGATGATATCGCCGCAGCCTGCGATACGCTGCACGAGTTTGATTTACCTGAACAT
CTGGTGGTGGATTTCAGCCACGGTAACTGCCAGAAGCAGCACCGTCGCCAGTTAGAAGTT
TGTGAGGATATTTGTCAGCAAATCCGCAATGGCTCTACGGCGATTGCTGGAATTATGGCG
GAAAGTTTCCTGCGCGAAGGAACGCAAAAAATCGTCGGCAGTCAGCCGCTCACTTACGGT
CAATCCATTACCGACCCGTGTCTGGGCTGGGAGGATACCGAACGCCTGGTCGAAAAACTC
GCCTCTGCGGTAGATACCCGCTTCTGA
Protein Properties
Pfam Domain Function:
Protein Residues:348
Protein Molecular Weight:39489
Protein Theoretical pI:7
Signaling Regions:
  • None
Transmembrane Regions:
  • 31-51
  • 323-343
Protein Sequence:
>Lipopolysaccharide biosynthesis protein wzzE
MTQPMPGKPAEDAENELDIRGLFRTLWAGKLWIIGMGLAFALIALAYTFFARQEWSSTAI
TDRPTVNMLGGYYSQQQFLRNLDVRSNMASADQPSVMDEAYKEFVMQLASWDTRREFWLQ
TDYYKQRMVGNSKADAALLDEMINNIQFIPGDFTRAVNDSVKLIAETAPDANNLLRQYVA
FASQRAASHLNDELKGAWAARTIQMKAQVKRQEEVAKAIYDRRMNSIEQALKIAEQHNIS
RSATDVPAEELPDSEMFLLGRPMLQARLENLQAVGPAFDLDYDQNRAMLNTLNVGPTLDP
RFQTYRYLRTPEEPVKRDSPRRAFLMIMWGIVGGLIGAGVALTRRCSK
References
External Links:
ResourceLink
Uniprot ID:P0AG00
Uniprot Name:WZZE_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1742785
Ecogene ID:EG11295
Ecocyc:EG11295
ColiBase:b3785
Kegg Gene:b3785
EchoBASE ID:EB1272
CCDB:WZZE_ECOLI
BacMap:90111649
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Daniels, D. L., Plunkett, G. 3rd, Burland, V., Blattner, F. R. (1992). "Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes." Science 257:771-778. Pubmed: 1379743
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Meier-Dieter, U., Barr, K., Starman, R., Hatch, L., Rick, P. D. (1992). "Nucleotide sequence of the Escherichia coli rfe gene involved in the synthesis of enterobacterial common antigen. Molecular cloning of the rfe-rff gene cluster." J Biol Chem 267:746-753. Pubmed: 1730666