Acid stress chaperone HdeA (P0AES9)

Identification
Name:Acid stress chaperone HdeA
Synonyms:Not Available
Gene Name:hdeA
Enzyme Class:Not Available
Biological Properties
General Function:cellular response to stress
Specific Function:Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Important for survival of enteric bacteria in the acidic environment of the host stomach. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
cellular response to acidic pH
cellular response to stress
chaperone binding
outer membrane-bounded periplasmic space
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>333
atgaaaaaagtattaggcgttattcttggtggtctgcttcttctgccagttgtgagcaat
gcagcggatgcgcaaaaagcagctgataacaaaaaaccggtcaactcctggacctgtgaa
gatttcctggctgtggacgaatccttccagccaactgcagttggttttgctgaagcgctg
aacaacaaagataaaccagaagatgcggttttagatgttcagggtattgcaaccgtaacc
ccagctatcgttcaggcttgtactcaggataaacaagccaactttaaagataaagttaaa
ggcgaatgggacaaaattaagaaagatatgtaa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:110
Protein Molecular Weight:11857
Protein Theoretical pI:Not Available
PDB File:1BG8
Signaling Regions:
  • 1-21
Transmembrane Regions:Not Available
Protein Sequence:
>Acid stress chaperone HdeA
MKKVLGVILGGLLLLPVVSNAADAQKAADNKKPVNSWTCEDFLAVDESFQPTAVGFAEAL
NNKDKPEDAVLDVQGIATVTPAIVQACTQDKQANFKDKVKGEWDKIKKDM
References
External Links:
ResourceLink
Uniprot ID:P0AES9
Uniprot Name:HDEA_ECOLI
PDB ID:1BG8
CCDB:HDEA_ECOLI
General Reference:Not Available