ECMDB: Transcriptional regulator ModE (P0A9G8)

Identification

Name:

Transcriptional regulator ModE

Synonyms:

Not Available

Gene Name:

modE

Enzyme Class:

Not Available

Biological Properties

General Function:

transcription, DNA-templated

Specific Function:

The ModE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA region, upstream of the modABC operon, which contains an 8-base inverted repeat 5'-TAACGTTA-3' flanked by two CAT boxes. Acts also as an enhancer of the expression of genes coding for molybdoenzymes, both directly and indirectly. ModE also interacts with tungstate.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Not Available

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
ATP binding
ATP-binding cassette (ABC) transporter complex
cytoplasm
DNA binding
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
molybdate ion transmembrane transporter activity
molybdenum ion binding
sequence-specific DNA binding transcription factor activity
transcription, DNA-templated

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>789
atgcaggccgaaatccttctcacccttaagctccaacaaaaattattcgccgacccgcgc
cgcatttcgctactaaaacacattgcgctttccggttccattagccagggagcgaaagat
gccggtattagctataaaagcgcctgggatgccattaacgagatgaatcagttaagtgag
catattctggtcgagcgcgcaacaggcggtaaaggtggcggcggcgcagtactgacccgc
tatggtcagcgactgattcagctctatgacttactggcgcaaatccagcaaaaagccttt
gatgtgttaagtgacgatgacgccctgccgctgaacagcctgctggccgcgatctcacgt
ttttcactgcaaaccagcgcccgtaaccagtggttcggtaccatcaccgcccgcgatcat
gatgacgttcaacagcatgttgatgtcttactggctgacggaaaaacacgcctgaaagtc
gcaattaccgcacaaagcggcgcgcgtctggggctggatgaaggcaaagaagtgttgata
ttgctaaaagcgccgtgggtaggtattactcaggacgaggcggtcgcgcaaaacgctgac
aaccaattaccgggtattattagtcatattgagcgcggcgcagagcagtgcgaagtatta
atggcgctacccgacgggcaaacactgtgcgccacagtgccggtaaatgaagcgacttct
cttcagcaaggacagaatgtcacggcctactttaatgccgacagcgtgattatcgccacg
ctgtgctaa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

262

Protein Molecular Weight:

28280

Protein Theoretical pI:

Not Available

PDB File:

1B9M

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>Transcriptional regulator ModE
MQAEILLTLKLQQKLFADPRRISLLKHIALSGSISQGAKDAGISYKSAWDAINEMNQLSE
HILVERATGGKGGGGAVLTRYGQRLIQLYDLLAQIQQKAFDVLSDDDALPLNSLLAAISR
FSLQTSARNQWFGTITARDHDDVQQHVDVLLADGKTRLKVAITAQSGARLGLDEGKEVLI
LLKAPWVGITQDEAVAQNADNQLPGIISHIERGAEQCEVLMALPDGQTLCATVPVNEATS
LQQGQNVTAYFNADSVIIATLC

References

External Links:

Resource	Link
Uniprot ID:	P0A9G8
Uniprot Name:	MODE_ECOLI
PDB ID:	1B9M
CCDB:	MODE_ECOLI

General Reference:

Not Available