Ribose-5-phosphate isomerase A (P0A7Z0)

Identification
Name:Ribose-5-phosphate isomerase A
Synonyms:
  • Phosphoriboisomerase A
  • PRI
Gene Name:rpiA
Enzyme Class:
Biological Properties
General Function:Involved in ribose-5-phosphate isomerase activity
Specific Function:D-ribose 5-phosphate = D-ribulose 5-phosphate
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
  • Carbon fixation in photosynthetic organisms ec00710
  • Fructose and mannose metabolism ec00051
  • Metabolic pathways eco01100
  • Microbial metabolism in diverse environments ec01120
  • Pentose phosphate pathway ec00030
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.0D-Ribose-5-phosphate ↔ 1.0D-Ribulose 5-phosphate
ReactionCard
1.0Thumb ↔ 1.0D-Ribulose 5-phosphate
1.0D-Ribose-5-phosphate ↔ 1.0D-Ribulose 5-phosphate
ReactionCard
SMPDB Reactions:
1.0Thumb ↔ 1.0Thumb
1.0D-Ribulose 5-phosphate ↔ 1.0D-Ribose-5-phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.0D-Ribose-5-phosphate ↔ 1.0D-Ribulose 5-phosphate
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb
1.0D-Ribose-5-phosphate → 1.0D-Ribulose 5-phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB02033D-Ribose-5-phosphateMetaboCard
ECMDB04148D-Ribulose 5-phosphateMetaboCard
GO Classification:
Function
catalytic activity
intramolecular oxidoreductase activity
intramolecular oxidoreductase activity, interconverting aldoses and ketoses
isomerase activity
ribose-5-phosphate isomerase activity
Process
alcohol metabolic process
metabolic process
monosaccharide metabolic process
pentose metabolic process
pentose-phosphate shunt, non-oxidative branch
small molecule metabolic process
Gene Properties
Blattner:b2914
Gene OrientationCounterclockwise
Centisome Percentage:65.88
Left Sequence End3056688
Right Sequence End3057347
Gene Sequence:
>660 bp
GTGAAAGAGATTATTGATGGATTCCTTAAATTCCAGCGCGAGGCATTTCCGAAGCGGGAA
GCCTTGTTTAAACAGCTGGCGACACAGCAAAGCCCGCGCACACTTTTTATCTCCTGCTCC
GACAGCCGTCTGGTCCCTGAGCTGGTGACGCAACGTGAGCCTGGCGATCTGTTCGTTATT
CGCAACGCGGGCAATATCGTCCCTTCCTACGGGCCGGAACCCGGTGGCGTTTCTGCTTCG
GTGGAGTATGCCGTCGCTGCGCTTCGGGTATCTGACATTGTGATTTGTGGTCATTCCAAC
TGTGGCGCGATGACCGCCATTGCCAGCTGTCAGTGCATGGACCATATGCCTGCCGTCTCC
CACTGGCTGCGTTATGCCGATTCAGCCCGCGTCGTTAATGAGGCGCGCCCGCATTCCGAT
TTACCGTCAAAAGCTGCGGCGATGGTACGTGAAAACGTCATTGCTCAGTTGGCTAATTTG
CAAACTCATCCATCGGTGCGCCTGGCGCTCGAAGAGGGGCGGATCGCCCTGCACGGCTGG
GTCTACGACATTGAAAGCGGCAGCATCGCAGCTTTTGACGGCGCAACCCGCCAGTTTGTG
CCACTGGCCGCTAATCCTCGCGTTTGTGCCATACCGCTACGCCAACCGACCGCAGCGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:219
Protein Molecular Weight:22860
Protein Theoretical pI:5
PDB File:1KS2
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Ribose-5-phosphate isomerase A
MTQDELKKAVGWAALQYVQPGTIVGVGTGSTAAHFIDALGTMKGQIEGAVSSSDASTEKL
KSLGIHVFDLNEVDSLGIYVDGADEINGHMQMIKGGGAALTREKIIASVAEKFICIADAS
KQVDILGKFPLPVEVIPMARSAVARQLVKLGGRPEYRQGVVTDNGNVILDVHGMEILDPI
AMENAINAIPGVVTVGLFANRGADVALIGTPDGVKTIVK
References
External Links:
ResourceLink
Uniprot ID:P0A7Z0
Uniprot Name:RPIA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674481
PDB ID:1KS2
Ecogene ID:EG11443
Ecocyc:EG11443
ColiBase:b2914
Kegg Gene:b2914
EchoBASE ID:EB1413
CCDB:RPIA_ECOLI
BacMap:16130815
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Hove-Jensen, B., Maigaard, M. (1993). "Escherichia coli rpiA gene encoding ribose phosphate isomerase A." J Bacteriol 175:5628-5635. Pubmed: 8366047
  • Link, A. J., Robison, K., Church, G. M. (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18:1259-1313. Pubmed: 9298646
  • Rex, J. H., Aronson, B. D., Somerville, R. L. (1991). "The tdh and serA operons of Escherichia coli: mutational analysis of the regulatory elements of leucine-responsive genes." J Bacteriol 173:5944-5953. Pubmed: 1917830
  • Wilkins, M. R., Gasteiger, E., Tonella, L., Ou, K., Tyler, M., Sanchez, J. C., Gooley, A. A., Walsh, B. J., Bairoch, A., Appel, R. D., Williams, K. L., Hochstrasser, D. F. (1998). "Protein identification with N and C-terminal sequence tags in proteome projects." J Mol Biol 278:599-608. Pubmed: 9600841