Phosphopentomutase (P0A6K6)

Identification
Name:Phosphopentomutase
Synonyms:
  • Phosphodeoxyribomutase
Gene Name:deoB
Enzyme Class:
Biological Properties
General Function:Involved in catalytic activity
Specific Function:Phosphotransfer between the C1 and C5 carbon atoms of pentose
Cellular Location:Cytoplasm
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.0Deoxyribose 1-phosphate ↔ 1.0Deoxyribose 5-phosphate
ReactionCard
1.0alpha-D-Ribose 1-phosphate+1.0Thumb ↔ 1.0Thumb
1.0alpha-D-Ribose 1-phosphate + 1.0Ribose-1-phosphate ↔ 1.0D-Ribose-5-phosphate
ReactionCard
SMPDB Reactions:
1.0Thumb → 1.0Thumb
1.0D-Ribose-5-phosphate → 1.0Ribose-1-phosphate
ReactionCard
1.0Thumb → 1.0Deoxyribose 5-phosphate
1.0Deoxyribose 1-phosphate → 1.0Deoxyribose 5-phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.0Ribose-1-phosphate ↔ 1.0D-Ribose-5-phosphate
ReactionCard
1.0Thumb ↔ 1.0Thumb
1.0Deoxyribose 1-phosphate ↔ 1.0Deoxyribose 5-phosphate
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb
1.0Ribose-1-phosphate → 1.0D-Ribose-5-phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB02033D-Ribose-5-phosphateMetaboCard
ECMDB01351Deoxyribose 1-phosphateMetaboCard
ECMDB01031Deoxyribose 5-phosphateMetaboCard
ECMDB11688Ribose 1,5-bisphosphateMetaboCard
ECMDB04147Ribose-1-phosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
binding
catalytic activity
cation binding
intramolecular transferase activity
intramolecular transferase activity, phosphotransferases
ion binding
isomerase activity
magnesium ion binding
metal ion binding
phosphopentomutase activity
Process
biosynthetic process
cellular biosynthetic process
cellular metabolic compound salvage
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
Gene Properties
Blattner:b4383
Gene OrientationClockwise
Centisome Percentage:99.52
Left Sequence End4617626
Right Sequence End4618849
Gene Sequence:
>1224 bp
ATGAAAAAAATCGCGCTTATTATCGGCAGCATGATCGCGGGCGGTATTATTTCTGCGGCA
GGTTTTACCTGGGTTGCAAAGGCGGAACCGCCTGCAGAAAAAACGTCGACCGCAGAACGT
AAAATCTTATTCTGGTACGACCCAATGTATCCCAATACGCGGTTCGATAAACCAGGTAAA
TCGCCGTTTATGGATATGGATCTGGTGCCGAAATATGCCGATGAAGAGAGTTCTGCGTCT
GGTGTGCGCATTGACCCGACTCAGACGCAGAATCTGGGGGTGAAAACGGCTACCGTCACG
CGCGGACCGCTGACTTTTGCCCAGAGTTTCCCGGCGAATGTCAGTTACAACGAGTATCAG
TATGCCATTGTGCAGGCTCGCGCTGCCGGGTTTATCGACAAGGTGTATCCGCTTACCGTG
GGCGATAAAGTACAAAAGGGCACACCGCTTCTCGACCTGACCATTCCTGACTGGGTGGAA
GCGCAGAGTGAGTATTTACTGCTGCGCGAAACCGGCGGTACGGCGACCCAGACTGAAGGC
ATTCTTGAGCGGCTGCGACTGGCGGGAATGCCGGAGGCGGATATTCGCCGCCTGATCGCC
ACGCAAAAAATCCAGACTCGCTTTACGCTCAAAGCGCCCATTGATGGCGTGATCACCGCG
TTTGATCTGCGCGCGGGAATGAATATCGCCAAAGATAACGTGGTAGCGAAAATTCAGGGT
ATGGACCCGGTGTGGGTCACTGCTGCGATCCCGGAGTCTATCGCCTGGCTGGTGAAAGAT
GCCTCGCAGTTTACCCTCACCGTTCCGGCGCGACCGGATAAAACACTCACCATCCGCAAA
TGGACGCTGCTACCTGGCGTGGATGCCGCGACCCGCACGCTGCAGCTGCGTCTGGAAGTC
GACAACGCCGACGAGGCGCTAAAACCGGGCATGAACGCCTGGTTGCAACTCAACACCGCC
AGCGAACCGATGCTGCTCATTCCGTCACAAGCGCTGATTGATACCGGCAGCGAACAGCGG
GTGATTACCGTTGATGCCGACGGGCGCTTTGTACCGAAACGCGTTGCTGTTTTCCAGGCA
TCGCAAGGCGTCACCGCATTACGCTCTGGTCTGGCGGAAGGTGAAAAGGTGGTTTCCAGC
GGCCTGTTCCTGATTGATTCCGAAGCCAATATTTCTGGCGCACTGGAGCGGATGCGCTCT
GAAAGTGCTACCCATGCGCATTGA
Protein Properties
Pfam Domain Function:
Protein Residues:407
Protein Molecular Weight:44370
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Phosphopentomutase
MKRAFIMVLDSFGIGATEDAERFGDVGADTLGHIAEACAKGEADNGRKGPLNLPNLTRLG
LAKAHEGSTGFIPAGMDGNAEVIGAYAWAHEMSSGKDTPSGHWEIAGVPVLFEWGYFSDH
ENSFPQELLDKLVERANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIAC
HEETFGLDKLYELCEIAREELTNGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAP
TVLQKLVDEKHGQVVSVGKIADIYANCGITKKVKATGLDALFDATIKEMKEAGDNTIVFT
NFVDFDSSWGHRRDVAGYAAGLELFDRRLPELMSLLRDDDILILTADHGCDPTWTGTDHT
REHIPVLVYGPKVKPGSLGHRETFADIGQTLAKYFGTSDMEYGKAMF
References
External Links:
ResourceLink
Uniprot ID:P0A6K6
Uniprot Name:DEOB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4062198
Ecogene ID:EG10220
Ecocyc:EG10220
ColiBase:b4383
Kegg Gene:b4383
EchoBASE ID:EB0216
CCDB:DEOB_ECOLI
BacMap:16132200
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L., Blattner, F. R. (1995). "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Nucleic Acids Res 23:2105-2119. Pubmed: 7610040
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Valentin-Hansen, P., Hammer, K., Love Larsen, J. E., Svendsen, I. (1984). "The internal regulated promoter of the deo operon of Escherichia coli K-12." Nucleic Acids Res 12:5211-5224. Pubmed: 6087276
  • Zhang, J., Sprung, R., Pei, J., Tan, X., Kim, S., Zhu, H., Liu, C. F., Grishin, N. V., Zhao, Y. (2009). "Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli." Mol Cell Proteomics 8:215-225. Pubmed: 18723842