Identification
Name:Dephospho-CoA kinase
Synonyms:
  • Dephosphocoenzyme A kinase
Gene Name:coaE
Enzyme Class:
Biological Properties
General Function:Involved in dephospho-CoA kinase activity
Specific Function:Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Cellular Location:Cytoplasm (Probable)
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb
SMPDB Reactions:
1.0Pantetheine 4'-phosphate+1.0Thumb+1.0Thumb1.0Thumb+1.0Pyrophosphate
1.0Pantetheine 4'-phosphate + 1.0Adenosine triphosphate + 1.0pantotheine 4'-phosphate → 1.0Dephospho-CoA + 1.0Pyrophosphate
ReactionCard
1.0Thumb+1.0Thumb1.0Adenosine diphosphate+1.0Thumb+1.0Thumb
1.0Adenosine triphosphate + 1.0Dephospho-CoA → 1.0Adenosine diphosphate + 1.0Coenzyme A + 1.0ADP
ReactionCard
1.0Thumb+1.0Thumb1.0Thumb+1.0Adenosine diphosphate+1.0Thumb+1.0Thumb
1.0Dephospho-CoA + 1.0Adenosine triphosphate → 1.0Hydrogen ion + 1.0Adenosine diphosphate + 1.0Coenzyme A + 1.0ADP
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
Metabolites:
ECMDB IDNameView
ECMDB231693'-dephospho-CoAMetaboCard
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
ECMDB01423Coenzyme AMetaboCard
ECMDB01373Dephospho-CoAMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB23216pantotheine 4'-phosphateMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
dephospho-CoA kinase activity
kinase activity
nucleoside binding
purine nucleoside binding
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular metabolic process
coenzyme A biosynthetic process
coenzyme biosynthetic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
Gene Properties
Blattner:b0103
Gene OrientationCounterclockwise
Centisome Percentage:2.43
Left Sequence End112599
Right Sequence End113219
Gene Sequence:
>621 bp
ATGAGGTATATAGTTGCCTTAACGGGAGGCATTGGCAGTGGCAAGAGTACCGTTGCCAAT
GCGTTTGCTGATCTCGGAATTAACGTCATTGATGCCGATATTATTGCGCGTCAGGTGGTT
GAACCAGGTGCACCTGCGCTACATGCCATTGCTGATCACTTTGGCGCTAACATGATTGCT
GCTGATGGAACATTGCAGCGCCGGGCCTTGCGCGAGCGGATCTTCGCCAACCCGGAAGAG
AAAAACTGGCTTAACGCCCTGCTGCATCCGCTGATTCAGCAAGAGACGCAACACCAGATC
CAGCAAGCTACTTCCCCCTATGTACTGTGGGTTGTGCCATTGCTGGTAGAAAACTCACTG
TATAAAAAAGCGAATCGAGTGCTTGTGGTGGATGTCAGCCCAGAAACGCAACTTAAGCGC
ACCATGCAGCGCGATGATGTAACTCGCGAGCATGTCGAACAAATCCTTGCTGCTCAGGCA
ACGCGCGAAGCCCGCCTTGCCGTGGCAGATGACGTCATTGATAATAACGGCGCACCGGAT
GCTATCGCATCGGATGTTGCCCGCCTGCACGCACACTATTTGCAGCTTGCGTCGCAGTTT
GTCTCACAGGAAAAACCGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:206
Protein Molecular Weight:22622
Protein Theoretical pI:6
PDB File:1VIY
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Dephospho-CoA kinase
MRYIVALTGGIGSGKSTVANAFADLGINVIDADIIARQVVEPGAPALHAIADHFGANMIA
ADGTLQRRALRERIFANPEEKNWLNALLHPLIQQETQHQIQQATSPYVLWVVPLLVENSL
YKKANRVLVVDVSPETQLKRTMQRDDVTREHVEQILAAQATREARLAVADDVIDNNGAPD
AIASDVARLHAHYLQLASQFVSQEKP
References
External Links:
ResourceLink
Uniprot ID:P0A6I9
Uniprot Name:COAE_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674328
PDB ID:1VIY
Ecogene ID:EG12312
Ecocyc:EG12312
ColiBase:b0103
Kegg Gene:b0103
EchoBASE ID:EB2218
CCDB:COAE_ECOLI
BacMap:16128096
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Fountoulakis, M., Takacs, M. F., Berndt, P., Langen, H., Takacs, B. (1999). "Enrichment of low abundance proteins of Escherichia coli by hydroxyapatite chromatography." Electrophoresis 20:2181-2195. Pubmed: 10493123
  • Fujita, N., Mori, H., Yura, T., Ishihama, A. (1994). "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region." Nucleic Acids Res 22:1637-1639. Pubmed: 8202364
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Mishra, P., Park, P. K., Drueckhammer, D. G. (2001). "Identification of yacE (coaE) as the structural gene for dephosphocoenzyme A kinase in Escherichia coli K-12." J Bacteriol 183:2774-2778. Pubmed: 11292795