Identification
Name:Exodeoxyribonuclease I
Synonyms:Not Available
Gene Name:sbcB
Enzyme Class:
Biological Properties
General Function:RNA phosphodiester bond hydrolysis, exonucleolytic
Specific Function:Degrades single-stranded DNA (ssDNA) in a highly processive manner (PubMed:23609540). Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase (PubMed:1329027).
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:
Metabolites:
ECMDB IDNameView
GO Classification:
Function
3'-5'-exoribonuclease activity
DNA catabolic process
DNA repair
exodeoxyribonuclease I activity
magnesium ion binding
nucleic acid phosphodiester bond hydrolysis
RNA phosphodiester bond hydrolysis, exonucleolytic
single-stranded DNA binding
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>1428
atgatgaatgacggtaagcaacaatctacctttttgtttcacgattacgaaacctttggc
acgcaccccgcgttagatcgccctgcacagttcgcagccattcgcaccgatagcgaattc
aatgtcatcggcgaacccgaagtcttttactgcaagcccgctgatgactatttaccccag
ccaggagccgtattaattaccggtattaccccgcaggaagcacgggcgaaaggagaaaac
gaagccgcgtttgccgcccgtattcactcgctttttaccgtaccgaagacctgtattctg
ggctacaacaatgtgcgtttcgacgacgaagtcacacgcaacattttttatcgtaatttc
tacgatccttacgcctggagctggcagcatgataactcgcgctgggatttactggatgtt
atgcgtgcctgttatgccctgcgcccggaaggaataaactggcctgaaaatgatgacggt
ctaccgagctttcgccttgagcatttaaccaaagcgaatggtattgaacatagcaacgcc
cacgatgcgatggctgatgtgtacgccactattgcgatggcaaagctggtaaaaacgcgt
cagccacgcctgtttgattatctctttacccatcgtaataaacacaaactgatggcgttg
attgatgttccgcagatgaaacccctggtgcacgtttccggaatgtttggagcatggcgc
ggcaataccagctgggtggcaccgctggcgtggcatcctgaaaatcgcaatgccgtaatt
atggtggatttggcaggagacatttcgccattactggaactggatagcgacacattgcgc
gagcgtttatataccgcaaaaaccgatcttggcgataacgccgccgttccggttaagctg
gtgcatatcaataaatgtccggtgctggcccaggcgaatacgctacgcccggaagatgcc
gaccgactgggaattaatcgtcagcattgcctcgataacctgaaaattctgcgtgaaaat
ccgcaagtgcgcgaaaaagtggtggcgatattcgcggaagccgaaccgtttacgccttca
gataacgtggatgcacagctttataacggctttttcagtgacgcagatcgtgcagcaatg
aaaattgtgctggaaaccgagccgcgtaatttaccggcactggatatcacttttgttgat
aaacggattgaaaagctgttgttcaattatcgggcacgcaacttcccggggacgctggat
tatgccgagcagcaacgctggctggagcaccgtcgccaggtcttcacgccagagtttttg
cagggttatgctgatgaattgcagatgctggtacaacaatatgccgatgacaaagagaaa
gtggcgctgttaaaagcactttggcagtacgcggaagagattgtctaa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:475
Protein Molecular Weight:54500
Protein Theoretical pI:Not Available
PDB File:1FXX
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Exodeoxyribonuclease I
MMNDGKQQSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPEVFYCKPADDYLPQ
PGAVLITGITPQEARAKGENEAAFAARIHSLFTVPKTCILGYNNVRFDDEVTRNIFYRNF
YDPYAWSWQHDNSRWDLLDVMRACYALRPEGINWPENDDGLPSFRLEHLTKANGIEHSNA
HDAMADVYATIAMAKLVKTRQPRLFDYLFTHRNKHKLMALIDVPQMKPLVHVSGMFGAWR
GNTSWVAPLAWHPENRNAVIMVDLAGDISPLLELDSDTLRERLYTAKTDLGDNAAVPVKL
VHINKCPVLAQANTLRPEDADRLGINRQHCLDNLKILRENPQVREKVVAIFAEAEPFTPS
DNVDAQLYNGFFSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRARNFPGTLD
YAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYADDKEKVALLKALWQYAEEIV
References
External Links:
ResourceLink
Uniprot ID:P04995
Uniprot Name:EX1_ECOLI
PDB ID:1FXX
CCDB:EX1_ECOLI
General Reference:Not Available