Record Information
Version2.0
Creation Date2015-06-04 19:21:40 -0600
Update Date2015-09-17 15:42:02 -0600
Secondary Accession Numbers
  • ECMDB23841
Identification
Name:(S)-Lactaldehyde
Description:
Structure
Thumb
Synonyms:
  • (+-)-2-Hydroxypropanal
  • (S)-Lactaldehyde
  • 2-Hydroxypropanal
  • 2-Hydroxypropionaldehyde
  • a-Hydroxypropionaldehyde
  • alpha-Hydroxypropionaldehyde
  • Hydroxypropionaldehyde
  • L-2-Hydroxypropionaldehyde
  • L-Lactaldehyde
  • α-Hydroxypropionaldehyde
Chemical Formula:C3H6O2
Weight:Average: 74.079
Monoisotopic: 74.036779433
InChI Key:BSABBBMNWQWLLU-UHFFFAOYSA-N
InChI:InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3
CAS number:3913-64-2
IUPAC Name:(2S)-2-hydroxypropanal
Traditional IUPAC Name:L-lactaldehyde
SMILES:[H]C(=O)C(C)O
Chemical Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as alpha-hydroxyaldehydes. These are organic compounds containing an aldehyde substituted with a hydroxyl group on the adjacent carbon.
KingdomChemical entities
Super ClassOrganic compounds
ClassOrganic oxygen compounds
Sub ClassOrganooxygen compounds
Direct ParentAlpha-hydroxyaldehydes
Alternative Parents
Substituents
  • Alpha-hydroxyaldehyde
  • Secondary alcohol
  • Organic oxide
  • Hydrocarbon derivative
  • Short-chain aldehyde
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physical Properties
State:Not Available
Charge:0
Melting point:Not Available
Experimental Properties:
PropertyValueSource
Predicted Properties
PropertyValueSource
Water Solubility658.0 mg/mLALOGPS
logP-1ALOGPS
logP-0.63ChemAxon
logS0.95ALOGPS
pKa (Strongest Acidic)14ChemAxon
pKa (Strongest Basic)-3.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area37.3 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity17.91 m3·mol-1ChemAxon
Polarizability7.16 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Cytoplasm
Reactions:
SMPDB Pathways:
Propanoate metabolismPW000940 Pw000940Pw000940 greyscalePw000940 simple
KEGG Pathways:
  • Fructose and mannose metabolism ec00051
  • Glyoxylate and dicarboxylate metabolism ec00630
  • Microbial metabolism in diverse environments ec01120
  • Pentose and glucuronate interconversions ec00040
  • Propanoate metabolism ec00640
  • Pyruvate metabolism ec00620
EcoCyc Pathways:Not Available
Concentrations
Not Available
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-MSsplash10-056v-9000000000-fe4416498788a968e467View in MoNA
GC-MSGC-MS Spectrum - GC-MS (1 TMS)splash10-00fr-9300000000-12b08b93303d8cbf5c3aView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-004i-9000000000-1aa2338222aff31e5e0fView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-056r-9000000000-c450e557b2fe7c5dc5a1View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a6r-9000000000-dceca37df952939d1084View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-00di-9000000000-cd6930d73efb436bc0ffView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-00di-9000000000-97d1b594dd3b1d9b08b8View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a4i-9000000000-90fa8913085480b29a8aView in MoNA
References
References:Not Available
Synthesis Reference:Not Available
Material Safety Data Sheet (MSDS)Not Available
External Links:
ResourceLink
CHEBI ID18041
HMDB IDHMDB03052
Pubchem Compound ID439231
Kegg IDC00424
ChemSpider ID388368
Wikipedia IDLactaldehyde
BioCyc IDNot Available

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
(R)-propane-1,2-diol + NAD(+) = (R)- lactaldehyde + NADH
Gene Name:
fucO
Uniprot ID:
P0A9S1
Molecular weight:
40644
Reactions
(R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + NADH.
(S)-propane-1,2-diol + NAD(+) = (S)-lactaldehyde + NADH.
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions. In E.coli, an important role of gldA is also likely to regulate the intracellular level of dihydroxyacetone by catalyzing the reverse reaction, i.e. the conversion of dihydroxyacetone into glycerol. Possesses a broad substrate specificity, since it is also able to oxidize 1,2-propanediol and to reduce glycolaldehyde, methylglyoxal and hydroxyacetone into ethylene glycol, lactaldehyde and 1,2-propanediol, respectively
Gene Name:
gldA
Uniprot ID:
P0A9S5
Molecular weight:
38712
Reactions
Glycerol + NAD(+) = glycerone + NADH.
General function:
Involved in metal ion binding
Specific function:
L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde
Gene Name:
fucA
Uniprot ID:
P0AB87
Molecular weight:
23775
Reactions
L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.
General function:
Involved in oxidoreductase activity
Specific function:
Acts on lactaldehyde as well as other aldehydes
Gene Name:
aldA
Uniprot ID:
P25553
Molecular weight:
52272
Reactions
(S)-lactaldehyde + NAD(+) + H(2)O = (S)-lactate + NADH.
Glycolaldehyde + NAD(+) + H(2)O = glycolate + NADH.
General function:
Involved in metal ion binding
Specific function:
Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde
Gene Name:
rhaD
Uniprot ID:
P32169
Molecular weight:
30145
Reactions
L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.
General function:
Involved in carbon-carbon lyase activity
Specific function:
Catalyzes the reversible retro-aldol cleavage of 2-keto- 3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3- deoxy-L-mannonate, 2-keto-3-deoxy-L-lyxonate and 4-hydroxy-2- ketoheptane-1,7-dioate (HKHD) are also reasonably good substrates, although 2-keto-3-deoxy-L-rhamnonate is likely to be the physiological substrate
Gene Name:
rhmA
Uniprot ID:
P76469
Molecular weight:
28916
Reactions
2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (R)-lactaldehyde.