2.02015-06-04 19:13:10 -06002015-08-05 16:22:05 -0600ECMDB23840M2MDB004852alpha-D-Ribose 1,2-cyclic phosphate 5-phosphateA ribose bisphosphate that is the cyclic-1,2-phosphate derivative of 5-phospho-α-D-ribose5-O-phosphono-a-D-Ribofuranose 1,2-(hydrogen phosphate)5-O-phosphono-a-D-Ribofuranose 1,2-(hydrogen phosphoric acid)5-O-phosphono-alpha-D-Ribofuranose 1,2-(hydrogen phosphate)5-O-phosphono-alpha-D-Ribofuranose 1,2-(hydrogen phosphoric acid)5-O-phosphono-α-D-ribofuranose 1,2-(hydrogen phosphate)5-O-phosphono-α-D-ribofuranose 1,2-(hydrogen phosphoric acid)5-Phospho-α-D-ribose 1,2-cyclic phosphatea-D-Ribose 1,2-cyclic phosphate 5-phosphatea-D-Ribose 1,2-cyclic phosphoric acid 5-phosphoric acidalpha-D-Ribose 1,2-cyclic phosphoric acid 5-phosphoric acidPRCPα-D-ribose 1,2-cyclic phosphate 5-phosphateα-D-Ribose 1,2-cyclic phosphate 5-phosphateα-D-ribose 1,2-cyclic phosphoric acid 5-phosphoric acidα-D-Ribose 1,2-cyclic phosphoric acid 5-phosphoric acidC5H10O10P2292.073291.974920518{[(3aR,5R,6R,6aR)-2,6-dihydroxy-2-oxo-tetrahydro-2H-2λ⁵-furo[2,3-d][1,3,2]dioxaphosphol-5-yl]methoxy}phosphonic acid[(3aR,5R,6R,6aR)-2,6-dihydroxy-2-oxo-tetrahydro-2λ⁵-furo[2,3-d][1,3,2]dioxaphosphol-5-yl]methoxyphosphonic acidO[C@@H]1[C@@H](COP(O)(O)=O)O[C@@H]2OP(O)(=O)O[C@H]12InChI=1S/C5H10O10P2/c6-3-2(1-12-16(7,8)9)13-5-4(3)14-17(10,11)15-5/h2-6H,1H2,(H,10,11)(H2,7,8,9)/t2-,3-,4-,5-/m1/s1OXGUIUWFXGIWNM-TXICZTDVSA-Nlogp-1.16logs-1.15solubility2.06e+01 g/llogp-1.7pka_strongest_acidic1.04pka_strongest_basic-3.7iupac{[(3aR,5R,6R,6aR)-2,6-dihydroxy-2-oxo-tetrahydro-2H-2λ⁵-furo[2,3-d][1,3,2]dioxaphosphol-5-yl]methoxy}phosphonic acidaverage_mass292.073mono_mass291.974920518smilesO[C@@H]1[C@@H](COP(O)(O)=O)O[C@@H]2OP(O)(=O)O[C@H]12formulaC5H10O10P2inchiInChI=1S/C5H10O10P2/c6-3-2(1-12-16(7,8)9)13-5-4(3)14-17(10,11)15-5/h2-6H,1H2,(H,10,11)(H2,7,8,9)/t2-,3-,4-,5-/m1/s1inchikeyOXGUIUWFXGIWNM-TXICZTDVSA-Npolar_surface_area151.98refractivity47.93polarizability21.28rotatable_bond_count3acceptor_count7donor_count4physiological_charge-3formal_charge0Phosphonate and phosphinate metabolismec00440methylphosphonate degradation IThe pathway of methylphosphonate degradation starts with methylphosphonate being degrade by an ATP driven methylphosphonate degradation complex resulting in a alpha-D-ribose-1-methylphosphonate-5-triphosphate. This compound in turn is degraded by a water driven RPnTP hydrolase resulting in the release of a hydrogen ion, a pyrophosphate and a alpha-Dribose-1-methylphosphonate 5-phosphate. The latter compound is then involved with a carbon-phosphorous lyase resulting in the release of a methane and a 5-phospho-alpha-D-ribose 1,2-cyclic phosphate. This compound in turn gets degraded by a water driven 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase resulting in the release of a hydrogen ion and a alpha-D-ribose 1,5-biphosphate.PW002065MetabolicSpecdb::CMs1085621Specdb::EiMs3367Specdb::MsMs28442Specdb::MsMs28443Specdb::MsMs28444Specdb::MsMs35000Specdb::MsMs35001Specdb::MsMs35002C20440Phosphoribosyl 1,2-cyclic phosphodiesteraseP16692PHNP_ECOLIphnPhttp://ecmdb.ca/proteins/P16692.xmlAlpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyaseP16688PHNJ_ECOLIphnJhttp://ecmdb.ca/proteins/P16688.xmlalpha-D-Ribose 1-methylphosphonate 5-phosphate <> alpha-D-Ribose 1,2-cyclic phosphate 5-phosphate + MethaneR10204 alpha-D-Ribose 1-methylphosphonate 5-phosphate > Methane + alpha-D-Ribose 1,2-cyclic phosphate 5-phosphatePW_R006037alpha-D-Ribose 1,2-cyclic phosphate 5-phosphate + Water > Hydrogen ion + Ribose 1,5-bisphosphatePW_R006038alpha-D-Ribose 1-methylphosphonate 5-phosphate <> alpha-D-Ribose 1,2-cyclic phosphate 5-phosphate + Methanealpha-D-Ribose 1-methylphosphonate 5-phosphate <> alpha-D-Ribose 1,2-cyclic phosphate 5-phosphate + Methane