2.02012-08-09 09:16:17 -06002015-09-13 15:15:33 -0600ECMDB21448M2MDB001843PhosphonoacetateA simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.Phosphonoacetic acidC2H5O5P140.0319139.9874597822-phosphonoacetic acidphosphonoacetic acid4408-78-0OC(=O)CP(O)(O)=OInChI=1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)XUYJLQHKOGNDPB-UHFFFAOYSA-NSolidCytoplasmlogp-2.58logs-0.75solubility2.51e+01 g/lmelting_point143-146 oClogp-1.6pka_strongest_acidic1.64iupac2-phosphonoacetic acidaverage_mass140.0319mono_mass139.987459782smilesOC(=O)CP(O)(O)=OformulaC2H5O5PinchiInChI=1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)inchikeyXUYJLQHKOGNDPB-UHFFFAOYSA-Npolar_surface_area94.83refractivity23.63polarizability9.63rotatable_bond_count2acceptor_count5donor_count3physiological_charge-2formal_charge0Microbial metabolism in diverse environmentsec01120Phosphonate and phosphinate metabolismec00440Specdb::CMs1211Specdb::CMs22302Specdb::CMs31503Specdb::CMs38715Specdb::CMs131854Specdb::CMs139588Specdb::NmrOneD1991Specdb::NmrOneD41602Specdb::NmrOneD41603Specdb::NmrOneD41604Specdb::NmrOneD41605Specdb::NmrOneD41606Specdb::NmrOneD41607Specdb::NmrOneD41608Specdb::NmrOneD41609Specdb::NmrOneD41610Specdb::NmrOneD41611Specdb::NmrOneD41612Specdb::NmrOneD41613Specdb::NmrOneD41614Specdb::NmrOneD41615Specdb::NmrOneD41616Specdb::NmrOneD41617Specdb::NmrOneD41618Specdb::NmrOneD41619Specdb::NmrOneD41620Specdb::NmrOneD41621Specdb::NmrOneD166375Specdb::NmrOneD166578Specdb::MsMs2364Specdb::MsMs2365Specdb::MsMs2366Specdb::MsMs6008Specdb::MsMs6009Specdb::MsMs6010Specdb::MsMs6011Specdb::MsMs6012Specdb::MsMs10997Specdb::MsMs10998Specdb::MsMs10999Specdb::MsMs17669Specdb::MsMs17670Specdb::MsMs17671Specdb::MsMs446847Specdb::MsMs446848Specdb::MsMs446849Specdb::MsMs446850Specdb::MsMs446851Specdb::MsMs2236346Specdb::MsMs2237026Specdb::MsMs2238437Specdb::MsMs2391253Specdb::MsMs2391254Specdb::MsMs2391255Specdb::NmrTwoD1926HMDB04110546531C0568215732PAEPAEvan der Werf, M. J., Overkamp, K. M., Muilwijk, B., Coulier, L., Hankemeier, T. (2007). "Microbial metabolomics: toward a platform with full metabolome coverage." Anal Biochem 370:17-25.17765195Abendroth A, Lin I, Slobedman B, Ploegh H, Arvin AM: Varicella-zoster virus retains major histocompatibility complex class I proteins in the Golgi compartment of infected cells. J Virol. 2001 May;75(10):4878-88.11312359Sairenji T, Hinuma Y, Sekizawa T, Yoshida M: Appearance of early and late components of Epstein-Barr virus-associated membrane antigen in Daudi cells superinfected with P3HR-1 virus. J Gen Virol. 1978 Jan;38(1):111-20.202665Dellinger Douglas J; Sheehan David M; Christensen Nanna K; Lindberg James G; Caruthers Marvin H Solid-phase chemical synthesis of phosphonoacetate and thiophosphonoacetate oligodeoxynucleotides. Journal of the American Chemical Society (2003), 125(4), 940-50.http://hmdb.ca/system/metabolites/msds/000/003/691/original/HMDB04110.pdf?1358462704conserved proteinP0AFJ1yjdMhttp://ecmdb.ca/proteins/P0AFJ1.xmlPhosphonoacetate + Water <> Acetic acid + PhosphateR00318Phosphonoacetate + Water <> Acetic acid + Phosphate