2.02012-08-03 15:09:30 -06002015-06-03 17:21:25 -0600ECMDB21406M2MDB0018012-Mercapto-1-methylimidazole2-Mercapto-1-methylimidazole is a thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme. [PubChem]1,3-Dihydro-1-methyl-2H-imidazole-2-thione1-Methyl-1,3-dihydro-2H-imidazole-2-thione1-Methyl-1,3-dihydroimidazole-2-thione1-Methyl-2-imidazolethiol1-Methyl-2-mercapto-Imidazole1-Methyl-2-mercaptoimidazole1-Methyl-4-Imidazoline-2-thione1-Methyl-Imidazole-2-thio1-Methyl-Imidazole-2-thiol1-Methylimidazole-2(3H)-thione1-Methylimidazole-2-thiol1-Methylimidazole-2-thione1-Metylo 2 merkaptoimidazolem2-MercaptomethylimidazoleBasolanDanantizolFavistanFrentiroxMercaptazoleMercasolylMercazoleMercazolylMerkastanMerkazolilMetazoloMethamazoleMethiamazoleMethimazolMethimazoleMethylmercaptoimidazoleMetizolMetothyrinMetothyrineMetotirinN-Methyl-2-mercaptoimidazoleStrumazolStrumazoleTapazoleTapuzoleThacapzolThiamazolThiamazoleThiamazolumThimazoleThycapsolThycapzolThymidazolThymidazoleTiamazolUSAF EL-30C4H6N2S114.169114.0251688921-methyl-2,3-dihydro-1H-imidazole-2-thionemethimazole60-56-0CN1C=CNC1=SInChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)PMRYVIKBURPHAH-UHFFFAOYSA-NSolidCytoplasmlogp-0.38logs-1.00solubility1.13e+01 g/lmelting_point146 oClogp0.75pka_strongest_acidic10.41pka_strongest_basic-3iupac1-methyl-2,3-dihydro-1H-imidazole-2-thioneaverage_mass114.169mono_mass114.025168892smilesCN1C=CNC1=SformulaC4H6N2SinchiInChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)inchikeyPMRYVIKBURPHAH-UHFFFAOYSA-Npolar_surface_area15.27refractivity33.23polarizability11.64rotatable_bond_count0acceptor_count0donor_count1physiological_charge0formal_charge0Specdb::CMs9432Specdb::CMs162415Specdb::NmrOneD153250Specdb::NmrOneD153251Specdb::NmrOneD153252Specdb::NmrOneD153253Specdb::NmrOneD153254Specdb::NmrOneD153255Specdb::NmrOneD153256Specdb::NmrOneD153257Specdb::NmrOneD153258Specdb::NmrOneD153259Specdb::NmrOneD153260Specdb::NmrOneD153261Specdb::NmrOneD153262Specdb::NmrOneD153263Specdb::NmrOneD153264Specdb::NmrOneD153265Specdb::NmrOneD153266Specdb::NmrOneD153267Specdb::NmrOneD153268Specdb::NmrOneD153269Specdb::MsMs440999Specdb::MsMs441000Specdb::MsMs441001Specdb::MsMs441002Specdb::MsMs446600Specdb::MsMs446601Specdb::MsMs446602Specdb::MsMs446603Specdb::MsMs446604Specdb::MsMs2239831Specdb::MsMs2254956Specdb::MsMs2255639Specdb::MsMs2257009Specdb::MsMs2257564Specdb::MsMs2258993Specdb::MsMs2259598Specdb::MsMs34403Specdb::MsMs34404Specdb::MsMs34405Specdb::MsMs3218857Specdb::MsMs3218858Specdb::MsMs3218859Specdb::MsMs27845Specdb::MsMs27846Specdb::MsMs2784713499071131173C07190MMZIshii, N., Nakahigashi, K., Baba, T., Robert, M., Soga, T., Kanai, A., Hirasawa, T., Naba, M., Hirai, K., Hoque, A., Ho, P. Y., Kakazu, Y., Sugawara, K., Igarashi, S., Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., Arakawa, K., Iwata, N., Toya, Y., Nakayama, Y., Nishioka, T., Shimizu, K., Mori, H., Tomita, M. (2007). "Multiple high-throughput analyses monitor the response of E. coli to perturbations." Science 316:593-597.1737977648 mM Na2HPO4, 22 mM KH2PO4, 10 mM NaCl, 45 mM (NH4)2SO4, supplemented with 1 mM MgSO4, 1 mg/l thiamine·HCl, 5.6 mg/l CaCl2, 8 mg/l FeCl3, 1 mg/l MnCl2·4H2O, 1.7 mg/l ZnCl2, 0.43 mg/l CuCl2·2H2O, 0.6 mg/l CoCl2·2H2O and 0.6 mg/l Na2MoO4·2H2O. 4 g/L GlucoBioreactor, pH controlled, O2 and CO2 controlled, dilution rate: 0.2/h186.0uM0.037 oCBW25113Stationary Phase, glucose limited7440000Ishii, N., Nakahigashi, K., Baba, T., Robert, M., Soga, T., Kanai, A., Hirasawa, T., Naba, M., Hirai, K., Hoque, A., Ho, P. Y., Kakazu, Y., Sugawara, K., Igarashi, S., Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., Arakawa, K., Iwata, N., Toya, Y., Nakayama, Y., Nishioka, T., Shimizu, K., Mori, H., Tomita, M. (2007). "Multiple high-throughput analyses monitor the response of E. coli to perturbations." Science 316:593-597.17379776