2.02012-07-30 14:55:06 -06002015-06-03 17:21:00 -0600ECMDB21246M2MDB001654MolybdateMolybdate is a compound containing an oxoanion with molybdenum in its highest oxidation state of 6. Molybdenum can form a very large range of such oxoanions which can be discrete structures or polymeric extended structures, although the latter are only found in the solid state.The larger oxoanions are members of group of compounds termed polyoxometalates, and because they contain only one type of metal atom are often called isopolymetalates. The discrete molybdenum oxoanions range in size from the simplest MoO42_, found in potassium molybdate up to extremely large structures found in isopoly-molybdenum blues that contain for example 154 Mo atoms. The behaviour of molybdenum is different from the other elements in group 6. Molybdate is involved in the molybdenum cofactor biosynthesis pathway. Molybdate reacts with molybdopterin-AMP to produce molybdenum cofactor, AMP, and H2O.MolybdateMolybdate ionMolybdatesMolybdic acidMolybdic acid ionMoO4-2MoO42-MoO<sub>4</sub><sup>-2</sup>MoO<sub>4</sub><sup>2-</sup>Tetraoxidomolybdate(2)Tetraoxidomolybdate(6)Tetraoxidomolybdic acid(2)Tetraoxidomolybdic acid(6)[MoO4]2H2MoO4161.95163.900716398dihydroxydioxomolybdenumbis(ylium)dihydroxydioxomolybdenumbis(ylium)14259-85-9O[Mo](O)(=O)=OInChI=1S/Mo.2H2O.2O/h;2*1H2;;/q+2;;;;/p-2VLAPMBHFAWRUQP-UHFFFAOYSA-LSolidCytosolExtra-organismPeriplasmlogp-1.8pka_strongest_acidic-2.3iupacdihydroxydioxomolybdenumbis(ylium)average_mass161.95mono_mass163.900716398smilesO[Mo](O)(=O)=OformulaH2MoO4inchiInChI=1S/Mo.2H2O.2O/h;2*1H2;;/q+2;;;;/p-2inchikeyVLAPMBHFAWRUQP-UHFFFAOYSA-Lpolar_surface_area74.6refractivity8.02polarizability6.51rotatable_bond_count0acceptor_count4donor_count2physiological_charge0formal_charge2ABC transportersec02010GTP degradationGTP, produced in the nucleotide de novo biosyntheis pathway, interacts with a water molecule through a GTP cyclohydrolase resulting in a formate, hydrogen ion and a 7,8-dihydroneopterin 3'-triphosphate. The latter compound interacts with a water molecule through a dihydroneopterin triphosphate pyrophosphohydrolase resulting in the release of a pyrophosphate, a hydrogen ion and a 7,8-dihydroneopterin 3'-phosphate. The latter compound interacts with water spontaneously resulting in the release of a phosphate and a 7,8 dihydroneopterin. The latter compound interacts with a dihydroneopterin aldolase resulting in the release of a glycolaldehyde and a 6-hydroxymethyl-7,8-dihydropterin. This compound then is then diphosphorylated by reacting with a ATP driven 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase resulting in the release of a hydrogen ion, an AMP and 6-hydroxymethyl-7,8-dihydropterin diphosphate.
GTP interacts with a cyclic pyranopterin monophosphate synthase resulting in the release of a diphosphate and a cyclic pyranopterin phosphate. The latter compound interacts with a thiocarboxylated small subunit of molybdopterin synthase (a protein) and a water molecule through a molybdopterin synthase resulting in the release of 4 hydrogen ions, 2 small subunits of molybdopterin synthase and a molybdopterin. The molybdopterin interacts with an ATP and a hydrogen ion through a molybdopterin adenylyltransferase resulting in the release of a diphosphate and a molybdopterin adenine dinucleotide.PW001888Metabolicmolybdenum cofactor biosynthesisPWY-6823HMDB122602462123023C0623236264CPD-3MolybdateKeseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590.21097882Sulfate/thiosulfate import ATP-binding protein cysAP16676CYSA_ECOLIcysAhttp://ecmdb.ca/proteins/P16676.xmlSulfate transport system permease protein cysWP0AEB0CYSW_ECOLIcysWhttp://ecmdb.ca/proteins/P0AEB0.xmlMolybdenum transport system permease protein modBP0AF01MODB_ECOLImodBhttp://ecmdb.ca/proteins/P0AF01.xmlSulfate transport system permease protein cysTP16701CYST_ECOLIcysUhttp://ecmdb.ca/proteins/P16701.xmlSulfate-binding proteinP0AG78SUBI_ECOLIsbphttp://ecmdb.ca/proteins/P0AG78.xmlMolybdopterin molybdenumtransferaseP12281MOEA_ECOLImoeAhttp://ecmdb.ca/proteins/P12281.xmlThiosulfate-binding proteinP16700CYSP_ECOLIcysPhttp://ecmdb.ca/proteins/P16700.xmlMolybdenum import ATP-binding protein ModCP09833MODC_ECOLImodChttp://ecmdb.ca/proteins/P09833.xmlMolybdate-binding periplasmic proteinP37329MODA_ECOLImodAhttp://ecmdb.ca/proteins/P37329.xmlSulfate/thiosulfate import ATP-binding protein cysAP16676CYSA_ECOLIcysAhttp://ecmdb.ca/proteins/P16676.xmlSulfate transport system permease protein cysWP0AEB0CYSW_ECOLIcysWhttp://ecmdb.ca/proteins/P0AEB0.xmlMolybdenum transport system permease protein modBP0AF01MODB_ECOLImodBhttp://ecmdb.ca/proteins/P0AF01.xmlSulfate transport system permease protein cysTP16701CYST_ECOLIcysUhttp://ecmdb.ca/proteins/P16701.xmlSulfate-binding proteinP0AG78SUBI_ECOLIsbphttp://ecmdb.ca/proteins/P0AG78.xmlOuter membrane protein NP77747OMPN_ECOLIompNhttp://ecmdb.ca/proteins/P77747.xmlThiosulfate-binding proteinP16700CYSP_ECOLIcysPhttp://ecmdb.ca/proteins/P16700.xmlOuter membrane pore protein EP02932PHOE_ECOLIphoEhttp://ecmdb.ca/proteins/P02932.xmlOuter membrane protein FP02931OMPF_ECOLIompFhttp://ecmdb.ca/proteins/P02931.xmlMolybdenum import ATP-binding protein ModCP09833MODC_ECOLImodChttp://ecmdb.ca/proteins/P09833.xmlOuter membrane protein CP06996OMPC_ECOLIompChttp://ecmdb.ca/proteins/P06996.xmlMolybdate-binding periplasmic proteinP37329MODA_ECOLImodAhttp://ecmdb.ca/proteins/P37329.xmlAdenosine triphosphate + Water + Molybdate > ADP + Hydrogen ion + Molybdate + PhosphateABC-19-RXNAdenosine triphosphate + Water + Molybdate > ADP + Hydrogen ion + Molybdate + PhosphateABC-19-RXN2 Hydrogen ion + Molybdate + Adenylated molybdopterin > Adenosine monophosphate + Copper + Water + MolybdopterinAdenylated molybdopterin + Molybdate <> Molybdoenzyme molybdenum cofactor + Adenosine monophosphate + Water + Molybdoenzyme molybdenum cofactorR09735Adenosine triphosphate + Molybdate + Water > ADP + Phosphate + Molybdate + Hydrogen ionABC-19-RXNAdenosine triphosphate + Molybdate + Water > ADP + Phosphate + Molybdate + Hydrogen ionABC-19-RXNAdenylated molybdopterin + Molybdate > molybdenum cofactor + Adenosine monophosphate + WaterRXN-8348Adenosine triphosphate + Water + Molybdate > ADP + Inorganic phosphate + MolybdateAdenosine triphosphate + Water + Molybdate > ADP + Inorganic phosphate + MolybdateAdenylyl-molybdopterin + Molybdate > Molybdopterin + Adenosine monophosphateADP + Phosphate + 4 Hydrogen ion + Heme + Nickel(2+) + Iron chelate + Taurine + Molybdate + Magnesium + Fe3+ + Potassium + Polyamine + vitamin B12 + Sulfate + glycerol-3-phosphate + Phosphonate + D-Maltose <> Adenosine triphosphate +3 Hydrogen ion + WaterR00086RXN0-1061Adenylyl-molybdopterin + Hydrogen ion + Molybdate > Adenosine monophosphate + Water + molybdenum cofactorPW_R005941