Record Information
Version2.0
Creation Date2012-05-31 14:06:15 -0600
Update Date2015-09-13 12:56:14 -0600
Secondary Accession Numbers
  • ECMDB04139
Identification
Name:Potassium
Description:Potassium is an essential electrolyte and part of many minerals. Potassium ion is a major intracellular cation in bacteria, plants and animals. It is necessary for the function of all living cells. There are a number of of potassium transport systems that regulate the intracellular potassium concentration.
Structure
Thumb
Synonyms:
  • K+
  • Kalium
  • Potassium
  • Potassium (ion)
  • Potassium (K+)
  • Potassium cation
  • Potassium ion
  • Potassium ion (K+)
  • Potassium ion (K1+)
  • Potassium ion(+)
  • Potassium ion(1+)
  • Potassium monocation
  • Potassium(+)
  • Potassium(1+)
  • Potassium(1+) ion
  • Potassium(I) cation
Chemical Formula:K
Weight:Average: 39.0983
Monoisotopic: 38.963706861
InChI Key:NPYPAHLBTDXSSS-UHFFFAOYSA-N
InChI:InChI=1S/K/q+1
CAS number:7440-09-7
IUPAC Name:potassium(1+) ion
Traditional IUPAC Name:potassium(1+) ion
SMILES:[K+]
Chemical Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom.
KingdomChemical entities
Super ClassInorganic compounds
ClassHomogeneous metal compounds
Sub ClassHomogeneous alkali metal compounds
Direct ParentHomogeneous alkali metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous alkali metal
Molecular FrameworkNot Available
External Descriptors
Physical Properties
State:Solid
Charge:1
Melting point:63.2 °C
Experimental Properties:
PropertyValueSource
Predicted Properties
PropertyValueSource
logP0.2ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Cytoplasm
Reactions:
SMPDB Pathways:
Folate biosynthesisPW000908 Pw000908Pw000908 greyscalePw000908 simple
Pyrimidine metabolismPW000942 Pw000942Pw000942 greyscalePw000942 simple
Thiamin diphosphate biosynthesisPW002028 Pw002028Pw002028 greyscalePw002028 simple
purine nucleotides de novo biosynthesisPW000910 Pw000910Pw000910 greyscalePw000910 simple
purine nucleotides de novo biosynthesis 1435709748PW000960 Pw000960Pw000960 greyscalePw000960 simple
purine nucleotides de novo biosynthesis 2PW002033 Pw002033Pw002033 greyscalePw002033 simple
KEGG Pathways:
EcoCyc Pathways:Not Available
Concentrations
ConcentrationStrainMediaGrowth StatusGrowth SystemTemperatureDetails
9600± 1100 uMK1216 mM NaH2PO4; 32 mM Na2HPO4; 5 mM (NH4)2SO4; 40 mM NaCl; 5 mM KCl; 0.4 mM MgSO4, 55 mM glucoseStationary Phase (50 mM chloride in media)Shake flask37 oCPMID: 13909522
224000± 8000 uMK1216 mM NaH2PO4; 32 mM Na2HPO4; 5 mM (NH4)2SO4; 40 mM NaCl; 5 mM KCl; 0.4 mM MgSO4, 55 mM glucoseMid-Log Phase (50 mM chloride in media)Shake flask37 oCPMID: 13909522
225000± 25000 uMK-12Not AvailableNot AvailableNot AvailableNot Available1. Cybercell Database: http://ccdb.wishartlab.com/CCDB/cgi-bin/STAT_NEW.cgi
2. Phillips R., Kondev, J., Theriot, J. (2008) “Physical Biology of the Cell” Garland Science, New York, NY.
Find out more about how we convert literature concentrations.
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-9000000000-560fc6f738e9570ec8a2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-9000000000-560fc6f738e9570ec8a2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000i-9000000000-560fc6f738e9570ec8a2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-000i-9000000000-bcbe5ea7d5d32f6a9598View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-000i-9000000000-bcbe5ea7d5d32f6a9598View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-000i-9000000000-bcbe5ea7d5d32f6a9598View in MoNA
References
References:
  • Beede DK: Mineral and water nutrition. Vet Clin North Am Food Anim Pract. 1991 Jul;7(2):373-90. Pubmed: 1893277
  • Brooks G: Potassium additive algorithm for use in continuous renal replacement therapy. Nurs Crit Care. 2006 Nov-Dec;11(6):273-80. Pubmed: 17883675
  • Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. Pubmed: 22080510
  • Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. Pubmed: 21097882
  • Preuss HG: Diet, genetics and hypertension. J Am Coll Nutr. 1997 Aug;16(4):296-305. Pubmed: 9263178
  • Schaafsma A, de Vries PJ, Saris WH: Delay of natural bone loss by higher intakes of specific minerals and vitamins. Crit Rev Food Sci Nutr. 2001 May;41(4):225-49. Pubmed: 11401244
  • SCHULTZ, S. G., WILSON, N. L., EPSTEIN, W. (1962). "Cation transport in Escherichia coli. II. Intracellular chloride concentration." J Gen Physiol 46:159-166. Pubmed: 13909522
Synthesis Reference:Alberti, Augusto. Recovering potassium salts from the refuse liquor of the manufacture of tartaric acid. (1910), US 957295 19100510 CAN 4:13164 AN 1910:13164
Material Safety Data Sheet (MSDS)Download (PDF)
External Links:
ResourceLink
CHEBI ID26216
HMDB IDHMDB00586
Pubchem Compound ID813
Kegg IDC00238
ChemSpider ID791
WikipediaPotassium
BioCyc IDK+
EcoCyc IDK+
Ligand ExpoK

Enzymes

General function:
Involved in potassium-transporting ATPase activity
Specific function:
One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
Gene Name:
kdpA
Uniprot ID:
P03959
Molecular weight:
59189
Reactions
ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In).
General function:
Involved in nucleotide binding
Specific function:
One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
Gene Name:
kdpB
Uniprot ID:
P03960
Molecular weight:
72198
Reactions
ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In).
General function:
Involved in potassium-transporting ATPase activity
Specific function:
One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex
Gene Name:
kdpC
Uniprot ID:
P03961
Molecular weight:
20267
Reactions
ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In).
General function:
Not Available
Specific function:
Specific function unknown
Gene Name:
kdpF
Uniprot ID:
P36937
Molecular weight:
3072

Transporters

General function:
Involved in potassium-transporting ATPase activity
Specific function:
One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
Gene Name:
kdpA
Uniprot ID:
P03959
Molecular weight:
59189
Reactions
ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In).
General function:
Involved in nucleotide binding
Specific function:
One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
Gene Name:
kdpB
Uniprot ID:
P03960
Molecular weight:
72198
Reactions
ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In).
General function:
Involved in potassium-transporting ATPase activity
Specific function:
One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex
Gene Name:
kdpC
Uniprot ID:
P03961
Molecular weight:
20267
Reactions
ATP + H(2)O + K(+)(Out) = ADP + phosphate + K(+)(In).
General function:
Involved in transmembrane transport
Specific function:
Efflux pump driven by the proton motive force. Confers resistance to basic, aromatic and lipophilic drugs as well as neutral, non-aromatic, zwitterionic or non-aromatic hydrophilic antibiotics
Gene Name:
cmr
Uniprot ID:
P0AEY8
Molecular weight:
44320
General function:
Involved in cation transmembrane transporter activity
Specific function:
Low-affinity potassium transport system. Interacts with trk system potassium uptake protein trkA. TrkE increases the affinity of the system
Gene Name:
trkG
Uniprot ID:
P23849
Molecular weight:
53943
General function:
Involved in cation transmembrane transporter activity
Specific function:
According to PubMed:8496184 the natural activity of this protein is as a calcium/proton antiporter, but it can act as a weak sodium/proton antiporter. The presence of a preferred substrate and normal pH cytoplasmic values might prevent significant sodium/proton antiporter activity
Gene Name:
chaA
Uniprot ID:
P31801
Molecular weight:
39168
General function:
Involved in potassium ion transmembrane transporter activity
Specific function:
Responsible for the low-affinity transport of potassium into the cell, with the probable concomitant uptake of protons (symport system). Can also transport cesium
Gene Name:
kup
Uniprot ID:
P63183
Molecular weight:
69293
General function:
Involved in cation transmembrane transporter activity
Specific function:
Part of the constitutive potassium transport systems trkG and trkH. May regulate the transport activity of trkG and trkH systems. Binds to NAD+ and NADH
Gene Name:
trkA
Uniprot ID:
P0AGI8
Molecular weight:
50367
General function:
Involved in transporter activity
Specific function:
Non-specific porin
Gene Name:
ompN
Uniprot ID:
P77747
Molecular weight:
41220
General function:
Involved in transporter activity
Specific function:
Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
Gene Name:
phoE
Uniprot ID:
P02932
Molecular weight:
38922
General function:
Involved in cation transmembrane transporter activity
Specific function:
Low-affinity potassium transport system. Interacts with trk system potassium uptake protein trkA and requires trkE for transport activity
Gene Name:
trkH
Uniprot ID:
P0AFZ7
Molecular weight:
52959
General function:
Involved in nucleotide binding
Specific function:
Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides
Gene Name:
sapD
Uniprot ID:
P0AAH4
Molecular weight:
37660
General function:
Involved in solute:hydrogen antiporter activity
Specific function:
Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport
Gene Name:
kefC
Uniprot ID:
P03819
Molecular weight:
67795
General function:
Involved in transporter activity
Specific function:
OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
Gene Name:
ompF
Uniprot ID:
P02931
Molecular weight:
39333
General function:
Involved in solute:hydrogen antiporter activity
Specific function:
Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport
Gene Name:
kefB
Uniprot ID:
P45522
Molecular weight:
66411
General function:
Not Available
Specific function:
Specific function unknown
Gene Name:
kdpF
Uniprot ID:
P36937
Molecular weight:
3072
General function:
Involved in transporter activity
Specific function:
Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
Gene Name:
ompC
Uniprot ID:
P06996
Molecular weight:
40368
General function:
Involved in nucleotide binding
Specific function:
May play a role in the defense against osmotic shock
Gene Name:
kch
Uniprot ID:
P31069
Molecular weight:
46062