2.02012-05-31 10:25:39 -06002015-09-13 12:56:07 -0600ECMDB00289M2MDB000119Uric acidUric acid is a heterocyclic purine derivative that is the final oxidation product of purine metabolism. It is produced by the enzyme xanthine oxidase, which oxidizes oxypurines such as xanthine into uric acid.1H-Purine-2,6,8-triol2,6,8-Trihydroxypurine2,6,8-Trioxopurine2,6,8-Trioxypurine8-HydroxyxanthineLithateLithic acidPurine-2,6,8(1H,3H,9H)-trionePurine-2,6,8-(1H,3H,9H)-trioneTrioxopurineUrateUric acidC5H4N4O3168.1103168.0283400142,3,6,7,8,9-hexahydro-1H-purine-2,6,8-trioneuric acid69-93-2O=C1NC2=C(N1)C(=O)NC(=O)N2InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)LEHOTFFKMJEONL-UHFFFAOYSA-NSolidCytosollogp-1.12logs-1.98solubility1.76e+00 g/lmelting_point> 300 oClogp-1.5pka_strongest_acidic7.25pka_strongest_basic-6.5iupac2,3,6,7,8,9-hexahydro-1H-purine-2,6,8-trioneaverage_mass168.1103mono_mass168.028340014smilesO=C1NC2=C(N1)C(=O)NC(=O)N2formulaC5H4N4O3inchiInChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)inchikeyLEHOTFFKMJEONL-UHFFFAOYSA-Npolar_surface_area99.33refractivity45.63polarizability13.61rotatable_bond_count0acceptor_count3donor_count4physiological_charge0formal_charge0Purine metabolismec00230Microbial metabolism in diverse environmentsec01120Metabolic pathwayseco01100adenosine nucleotides degradationThe degradation of of adenosine nucleotides starts with AMP reacting with water through a nucleoside monophosphate phosphatase results in the release of phosphate and a adenosine. Adenosine reacts with water and hydrogen ion through an adenosine deaminase resulting in the release of ammonium and a inosine. Inosine reacts with phosphate through a inosine phosphorylase resulting in the release of an alpha-D-ribose-1-phosphate and an hypoxanthine. Hypoxanthine reacts with a water molecule and a NAD molecule through an hypoxanthine hydroxylase resulting in the release of an hydrogen ion, an NADH and a xanthine. Xanthine in turn is degraded by reacting with a water molecule and a NAD through xanthine NAD oxidoreductase resulting in the release of NADH, a hydrogen ion and urate.PW002091Metabolicadenosine nucleotides degradation IISALVADEHYPOX-PWYguanosine nucleotides degradation IIIPWY-6608Specdb::CMs521Specdb::CMs1798Specdb::CMs1827Specdb::CMs3199Specdb::CMs30708Specdb::CMs31115Specdb::CMs31116Specdb::CMs31919Specdb::CMs137909Specdb::CMs145643Specdb::EiMs1045Specdb::NmrOneD5049Specdb::NmrOneD326072Specdb::NmrOneD326073Specdb::NmrOneD326074Specdb::NmrOneD326075Specdb::NmrOneD326076Specdb::NmrOneD326077Specdb::NmrOneD326078Specdb::NmrOneD326079Specdb::NmrOneD326080Specdb::NmrOneD326081Specdb::MsMs489Specdb::MsMs490Specdb::MsMs491Specdb::MsMs21341Specdb::MsMs21342Specdb::MsMs21343Specdb::MsMs22892Specdb::MsMs22893Specdb::MsMs22894Specdb::MsMs440020Specdb::MsMs447345Specdb::MsMs2239914Specdb::MsMs2241783Specdb::MsMs2244113Specdb::MsMs2244370Specdb::MsMs2245751Specdb::MsMs2245995Specdb::MsMs2246210Specdb::MsMs2247814Specdb::MsMs2248059Specdb::MsMs2248203Specdb::MsMs2250186Specdb::MsMs2250226Specdb::MsMs2252163Specdb::MsMs2308149HMDB0028911751142C0036617775URATEURCUric acidKeseler, I. 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Helvetica Chimica Acta (1963), 46(4), 1426-8. http://hmdb.ca/system/metabolites/msds/000/000/210/original/HMDB00289.pdf?1358896166Putative xanthine dehydrogenase yagS FAD-binding subunitP77324YAGS_ECOLIyagShttp://ecmdb.ca/proteins/P77324.xmlPutative xanthine dehydrogenase yagR molybdenum-binding subunitP77489YAGR_ECOLIyagRhttp://ecmdb.ca/proteins/P77489.xmlXanthine dehydrogenase molybdenum-binding subunitQ46799XDHA_ECOLIxdhAhttp://ecmdb.ca/proteins/Q46799.xmlXanthine dehydrogenase FAD-binding subunitQ46800XDHB_ECOLIxdhBhttp://ecmdb.ca/proteins/Q46800.xmlXanthine dehydrogenase iron-sulfur-binding subunitQ46801XDHC_ECOLIxdhChttp://ecmdb.ca/proteins/Q46801.xmlPaoABC aldehyde oxidoreductase, 2Fe-2S subunitP77165paoAhttp://ecmdb.ca/proteins/P77165.xmlWater + NAD + Xanthine <> Hydrogen ion + NADH + Uric acidR02103RXN0-901Xanthine + NAD + Water > Uric acid + NADH + Hydrogen ionRXN0-901Xanthine + NAD + Water > Uric acid + NADH