Record Information
Version2.0
Creation Date2012-05-31 10:24:41 -0600
Update Date2015-09-13 15:15:18 -0600
Secondary Accession Numbers
  • ECMDB00243
Identification
Name:Pyruvic acid
Description:Pyruvic acid is an alpha-keto acid. It can be made from glucose through glycolysis, converted back to carbohydrates (such as glucose) via gluconeogenesis, or to fatty acids through acetyl-CoA. It can also be used to construct the amino acid alanine and be converted into ethanol. Pyruvic acid supplies energy to living cells through the citric acid cycle (also known as the Krebs cycle) when oxygen is present (aerobic respiration), and alternatively ferments to produce lactic acid when oxygen is lacking (fermentation).
Structure
Thumb
Synonyms:
  • α-ketopropionate
  • α-ketopropionic acid
  • 2-Oxo-propionate
  • 2-Oxo-propionic acid
  • 2-Oxopropanoate
  • 2-Oxopropanoic acid
  • 2-Oxopropionate
  • 2-Oxopropionic acid
  • A-Ketopropionate
  • A-Ketopropionic acid
  • Acetylformate
  • Acetylformic acid
  • Alpha-Ketopropionate
  • Alpha-Ketopropionic acid
  • BTS
  • Pyroracemate
  • Pyroracemic acid
  • Pyruvate
  • Pyruvic acid
  • α-Ketopropionate
  • α-Ketopropionic acid
Chemical Formula:C3H4O3
Weight:Average: 88.0621
Monoisotopic: 88.016043994
InChI Key:LCTONWCANYUPML-UHFFFAOYSA-N
InChI:InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)
CAS number:127-17-3
IUPAC Name:2-oxopropanoic acid
Traditional IUPAC Name:pyruvic acid
SMILES:CC(=O)C(O)=O
Chemical Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha-keto acids and derivatives. These are organic compounds containing an aldehyde substituted with a keto group on the adjacent carbon.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassKeto acids and derivatives
Sub ClassAlpha-keto acids and derivatives
Direct ParentAlpha-keto acids and derivatives
Alternative Parents
Substituents
  • Alpha-keto acid
  • Alpha-hydroxy ketone
  • Ketone
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Physical Properties
State:Liquid
Charge:-1
Melting point:13.8 °C
Experimental Properties:
PropertyValueSource
Water Solubility:1000.0 mg/ml [YALKOWSKY,SH & DANNENFELSER,RM (1992)]PhysProp
LogP:-0.517PhysProp
Predicted Properties
PropertyValueSource
Water Solubility134.0 mg/mLALOGPS
logP-0.38ALOGPS
logP0.066ChemAxon
logS0.18ALOGPS
pKa (Strongest Acidic)2.93ChemAxon
pKa (Strongest Basic)-9.6ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area54.37 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity17.99 m3·mol-1ChemAxon
Polarizability7.31 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Cytoplasm
Reactions:
Coenzyme A + 2 flavodoxin semi oxidized + Pyruvic acid <> Acetyl-CoA + Carbon dioxide +2 Flavodoxin reduced + Hydrogen ion
Coenzyme A + Pyruvic acid <> Acetyl-CoA + Formic acid
Phosphoenolpyruvic acid + N-Acetyl-D-glucosamine > N-Acetyl-D-Glucosamine 6-Phosphate + Pyruvic acid
Phosphoenolpyruvic acid + D-Glucose > Glucose 6-phosphate + Pyruvic acid
2-Ketobutyric acid + Hydrogen ion + Pyruvic acid > 2-Aceto-2-hydroxy-butyrate + Carbon dioxide
Hydrogen ion + 2 Pyruvic acid > (S)-2-Acetolactate + Carbon dioxide
Phosphoenolpyruvic acid + Arbutin > Arbutin 6-phosphate + Pyruvic acid
Coenzyme A + NAD + Pyruvic acid > Acetyl-CoA + Carbon dioxide + NADH
Phosphoenolpyruvic acid + 2(alpha-D-Mannosyl)-D-glycerate > 2(alpha-D-Mannosyl-6-phosphate)-D-glycerate + Pyruvic acid
L-Alanine + Pyridoxal 5'-phosphate > Pyridoxamine 5'-phosphate + Pyruvic acid
Dihydroxyacetone + Phosphoenolpyruvic acid > Dihydroxyacetone phosphate + Pyruvic acid
Chorismate + L-Glutamine <> 2-Aminobenzoic acid + L-Glutamate + Hydrogen ion + Pyruvic acid
L-Cystathionine + Water > L-Homocysteine + Ammonium + Pyruvic acid
Phosphoenolpyruvic acid + D-Mannose > Mannose 6-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + D-Fructose > Fructose 6-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + N-Acetylmannosamine > N-Acetyl-D-mannosamine 6-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + Glucosamine > Glucosamine 6-phosphate + Pyruvic acid
ADP + Hydrogen ion + Phosphoenolpyruvic acid <> Adenosine triphosphate + Pyruvic acid
Phosphoenolpyruvic acid + Galactitol > Galactitol 1-phosphate + Pyruvic acid
D-Lactic acid + NAD <> Hydrogen ion + NADH + Pyruvic acid
Phosphoenolpyruvic acid + D-Fructose > Fructose 1-phosphate + Pyruvic acid
alpha-Ketoglutarate + L-Alanine <> L-Glutamate + Pyruvic acid
Phosphoenolpyruvic acid + Sorbitol > Pyruvic acid + Sorbitol-6-phosphate
Phosphoenolpyruvic acid + Ascorbic acid > L-Ascorbate 6-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + D-Maltose > Maltose 6'-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + Trehalose > Pyruvic acid + Trehalose 6-phosphate
Phosphoenolpyruvic acid + Sucrose > Pyruvic acid + Sucrose-6-phosphate
Phosphoenolpyruvic acid + N-Acetyl-D-muramoate > N-Acetylmuramic acid 6-phosphate + Pyruvic acid
D-Alanine + Pyridoxal 5'-phosphate > Pyridoxamine 5'-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + Mannitol > Sorbitol-6-phosphate + Pyruvic acid
L-Lactic acid + Ubiquinone-8 > Pyruvic acid + Ubiquinol-8
L-Lactic acid + Menaquinone 8 > Menaquinol 8 + Pyruvic acid
L-Cysteine + Water > Hydrogen sulfide + Ammonium + Pyruvic acid
L-Serine > Ammonium + Pyruvic acid
Methylisocitric acid <> Pyruvic acid + Succinic acid
4-Hydroxy-2-oxopentanoate > Acetaldehyde + Pyruvic acid
D-Glyceraldehyde 3-phosphate + Hydrogen ion + Pyruvic acid <> Carbon dioxide + 1-Deoxy-D-xylulose 5-phosphate
Water + Isochorismate <> (2S,3S)-2,3-Dihydro-2,3-dihydroxybenzoate + Pyruvic acid
Water + Pyruvic acid + Ubiquinone-8 > Acetic acid + Carbon dioxide + Ubiquinol-8
4-Amino-4-deoxychorismate <> p-Aminobenzoic acid + Hydrogen ion + Pyruvic acid
D-Alanine + FAD + Water > FADH2 + Ammonium + Pyruvic acid
L-Malic acid + NAD > Carbon dioxide + NADH + Pyruvic acid
Adenosine triphosphate + Water + Pyruvic acid <> Adenosine monophosphate +2 Hydrogen ion + Phosphoenolpyruvic acid + Phosphate
(R)-Malate + NAD <> Carbon dioxide + NADH + Pyruvic acid
2-Keto-3-deoxy-6-phosphogluconic acid <> D-Glyceraldehyde 3-phosphate + Pyruvic acid
Hydrogen ion + Oxalacetic acid > Carbon dioxide + Pyruvic acid
D-Cysteine + Water > Hydrogen sulfide + Ammonium + Pyruvic acid
D-Lactic acid + Ubiquinone-8 > Pyruvic acid + Ubiquinol-8
2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate <> (1R,6R)-6-Hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + Pyruvic acid
D-Serine > Ammonium + Pyruvic acid
Phosphoenolpyruvic acid + Chitobiose > Diacetylchitobiose-6-phosphate + Pyruvic acid
L-Malic acid + NADP > Carbon dioxide + NADPH + Pyruvic acid
L-Aspartate-semialdehyde + Pyruvic acid > 2,3-Dihydrodipicolinic acid + Hydrogen ion +2 Water
Hydrogen cyanide + 3-Mercaptopyruvic acid + Cyanide <> Hydrogen ion + Pyruvic acid + Thiocyanate
2,3-diaminopropionate + Water >2 Ammonium + Pyruvic acid
5-Dehydro-4-deoxy-D-glucarate > Tartronate semialdehyde + Pyruvic acid
N-Acetylneuraminic acid + N-acetylneuraminate <> N-Acetylmannosamine + Pyruvic acid
alpha-Ketoisovaleric acid + L-Alanine <> Pyruvic acid + L-Valine + a-Ketoisovaleric acid
Water + L-Tryptophan <> Indole + Ammonium + Pyruvic acid
Chorismate <> 4-Hydroxybenzoic acid + Pyruvic acid
2-Dehydro-3-deoxy-D-galactonate-6-phosphate <> D-Glyceraldehyde 3-phosphate + Pyruvic acid
2-Acetolactate + Carbon dioxide <>2 Pyruvic acid
Pyruvic acid + Thiamine pyrophosphate <> 2-(a-Hydroxyethyl)thiamine diphosphate + Carbon dioxide
L-Lactic acid + 2 Ferricytochrome c + Ferricytochrome c <> Pyruvic acid +2 Ferrocytochrome c +2 Hydrogen ion + Ferrocytochrome c
Adenosine triphosphate + Pyruvic acid + Water <> Adenosine monophosphate + Phosphoenolpyruvic acid + Phosphate
Adenosine triphosphate + Pyruvic acid <> ADP + Phosphoenolpyruvic acid
Pyruvaldehyde + NAD + Water <> Pyruvic acid + NADH + Hydrogen ion
Acetyl-CoA + Formic acid <> Coenzyme A + Pyruvic acid
L-Malic acid + NAD <> Pyruvic acid + Carbon dioxide + NADH + Hydrogen ion
(R)-Malate + NAD <> Pyruvic acid + Carbon dioxide + NADH + Hydrogen ion
L-Malic acid + NADP <> Pyruvic acid + Carbon dioxide + NADPH + Hydrogen ion
L-Serine <> Pyruvic acid + Ammonia
D-Serine <> Pyruvic acid + Ammonia
(S)-2-Acetolactate + Carbon dioxide <>2 Pyruvic acid
L-Alanine + alpha-Ketoglutarate <> Pyruvic acid + L-Glutamate
Methylisocitric acid <> Pyruvic acid + Succinic acid
Guanosine triphosphate + Pyruvic acid <> Guanosine diphosphate + Phosphoenolpyruvic acid
4-Hydroxy-2-oxoglutaric acid <> Pyruvic acid + Glyoxylic acid
D-4-Hydroxy-2-oxoglutarate <> Pyruvic acid + Glyoxylic acid
L-Tryptophan + Water <> Indole + Pyruvic acid + Ammonia
D-Lactic acid + NAD <> Pyruvic acid + NADH + Hydrogen ion
Acetaldehyde + Pyruvic acid <> 4-Hydroxy-2-oxopentanoate
L-Cysteine + Water <> Hydrogen sulfide + Pyruvic acid + Ammonia
Chorismate + Ammonia <> 2-Aminobenzoic acid + Pyruvic acid + Water
Chorismate + L-Glutamine <> 2-Aminobenzoic acid + Pyruvic acid + L-Glutamate
2-Dehydro-3-deoxy-D-galactonate-6-phosphate <> Pyruvic acid + D-Glyceraldehyde 3-phosphate
dATP + Pyruvic acid <> dADP + Phosphoenolpyruvic acid
2 Reduced ferredoxin + Acetyl-CoA + Carbon dioxide + 2 Hydrogen ion + Oxidized ferredoxin <>2 Oxidized ferredoxin + Pyruvic acid + Coenzyme A + Reduced ferredoxin
L-Valine + Pyruvic acid <> alpha-Ketoisovaleric acid + L-Alanine
Cystathionine + Water <> L-Homocysteine + Ammonia + Pyruvic acid
L-Cystathionine + Water <> L-Homocysteine + Ammonia + Pyruvic acid
4-Hydroxybenzoic acid + Pyruvic acid <> Chorismate
Pyruvic acid + Enzyme N6-(lipoyl)lysine <> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Carbon dioxide + [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
N-Acetylneuraminic acid <> N-Acetylmannosamine + Pyruvic acid
dGTP + Pyruvic acid <> dGDP + Phosphoenolpyruvic acid
D-Cysteine + Water <> Hydrogen sulfide + Ammonia + Pyruvic acid
2-Dehydro-3-deoxy-L-rhamnonate <> Lactaldehyde + Pyruvic acid + (S)-Lactaldehyde
L-Aspartate-semialdehyde + Pyruvic acid <> 2,3-Dihydrodipicolinic acid +2 Water
Nucleoside triphosphate + Pyruvic acid <> NDP + Phosphoenolpyruvic acid
L-Cystine + Water <> Pyruvic acid + Ammonia + Thiocysteine
5-Dehydro-4-deoxy-D-glucarate <> Pyruvic acid + Tartronate semialdehyde
Isochorismate + Water <> (2S,3S)-2,3-Dihydro-2,3-dihydroxybenzoate + Pyruvic acid
2-Acetolactate + Thiamine pyrophosphate <> 2-(a-Hydroxyethyl)thiamine diphosphate + Pyruvic acid
3-Mercaptopyruvic acid + Sulfite <> Thiosulfate + Pyruvic acid
Hydrogen cyanide + 3-Mercaptopyruvic acid <> Thiocyanate + Pyruvic acid
Pyruvic acid + Ubiquinone-1 + Water <> Acetic acid + Ubiquinol-8 + Carbon dioxide
Tartronate semialdehyde + Pyruvic acid <> 2-Dehydro-3-deoxy-D-glucarate
(S)-2-Acetolactate + Thiamine pyrophosphate <> 2-(a-Hydroxyethyl)thiamine diphosphate + Pyruvic acid
Selenocystathionine + Water <> Selenohomocysteine + Ammonia + Pyruvic acid
Propanal + Pyruvic acid <> 4-Hydroxy-2-oxohexanoic acid
4-Amino-4-deoxychorismate <> p-Aminobenzoic acid + Pyruvic acid
2-Keto-3-deoxy-6-phosphogluconic acid <> D-Glyceraldehyde 3-phosphate + Pyruvic acid
Pyruvic acid + D-Glyceraldehyde 3-phosphate <> 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide
2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate <> (1R,6R)-6-Hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + Pyruvic acid
Pyruvic acid + 2-Ketobutyric acid <> 2-Aceto-2-hydroxy-butyrate + Carbon dioxide
Se-Methylselenocysteine + Water <> Pyruvic acid + Ammonia + Methaneselenol
an oxidized electron acceptor + L-Lactic acid > a reduced electron acceptor + Pyruvic acid
Pyruvic acid + hydroxylamine > pyruvic oxime + Water
Hydrogen ion + Pyruvic acid + Acetaldehyde > acetoin + Carbon dioxide
Phosphoenolpyruvic acid + Ascorbic acid > L-Ascorbate 6-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + 2(alpha-D-Mannosyl)-D-glycerate > 2(alpha-D-Mannosyl-6-phosphate)-D-glycerate + Pyruvic acid
D-Alanine + Pyridoxal 5'-phosphate <> Pyruvic acid + Pyridoxamine 5'-phosphate
Hydrogen ion + 3-Mercaptopyruvic acid > Pyruvic acid + Hydrogen sulfide
Arbutin + Phosphoenolpyruvic acid > Arbutin 6-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + b-D-Glucose > Glucose 6-phosphate + Pyruvic acid
N-Acetylmannosamine + Phosphoenolpyruvic acid > N-Acetyl-D-mannosamine 6-phosphate + Pyruvic acid
NAD + (R)-Malate > NADH + Carbon dioxide + Pyruvic acid
Dihydroxyacetone + Phosphoenolpyruvic acid > Dihydroxyacetone phosphate + Pyruvic acid
2,3-diaminopropanoate + Water > Hydrogen ion + Ammonia + Pyruvic acid
L-Serine > Hydrogen ion + Pyruvic acid + Ammonia
4-Hydroxy-2-oxoglutaric acid Glyoxylic acid + Pyruvic acid
Hydrogen ion + Pyruvic acid <> (<i>S</i>)-2-acetolactate + Carbon dioxide
Hydrogen ion + Pyruvic acid + 2-Ketobutyric acid > 2-Aceto-2-hydroxy-butyrate + Carbon dioxide
N-Acetylneuraminic acid <> N-Acetylmannosamine + Pyruvic acid
4-Amino-4-deoxychorismate <> Hydrogen ion + p-Aminobenzoic acid + Pyruvic acid
Oxoglutaric acid + L-Alanine <> L-Glutamate + Pyruvic acid
Chorismate + L-Glutamine > Hydrogen ion + 2-Aminobenzoic acid + Pyruvic acid + L-Glutamate
Chorismate > 4-Hydroxybenzoic acid + Pyruvic acid
L-Cystathionine + Water > Hydrogen ion + Pyruvic acid + Ammonia + L-Homocysteine
an electron-transfer-related quinone + Water + D-Alanine > an electron-transfer-related quinol + Ammonium + Pyruvic acid
D-Cysteine + Water <> Pyruvic acid + Hydrogen sulfide + Ammonia + Hydrogen ion
2-Dehydro-3-deoxy-D-galactonate-6-phosphate <> D-Glyceraldehyde 3-phosphate + Pyruvic acid
2-Keto-3-deoxy-D-gluconic acid D-Glyceraldehyde + Pyruvic acid
Pyruvic acid + L-Aspartate-semialdehyde <> Hydrogen ion + Water + 2,3-Dihydrodipicolinic acid
an electron-transfer-related quinone + D-Lactic acid > an electron-transfer-related quinol + Pyruvic acid
NAD + D-Lactic acid < Hydrogen ion + NADH + Pyruvic acid
D-Serine > Hydrogen ion + Pyruvic acid + Ammonia
Pyruvic acid + D-Glyceraldehyde 3-phosphate + Hydrogen ion > Carbon dioxide + 1-Deoxy-D-xylulose 5-phosphate
Water + Isochorismate <> Pyruvic acid + (2S,3S)-2,3-Dihydro-2,3-dihydroxybenzoate
5-Dehydro-4-deoxy-D-glucarate <> Pyruvic acid + Tartronate semialdehyde
2-Keto-3-deoxy-6-phosphogluconic acid > D-Glyceraldehyde 3-phosphate + Pyruvic acid
L-Cysteine + Water > Pyruvic acid + Ammonia + Hydrogen sulfide + Hydrogen ion
NAD + L-Malic acid > NADH + Carbon dioxide + Pyruvic acid
NADP + L-Malic acid > NADPH + Carbon dioxide + Pyruvic acid
Hydrogen cyanide + 3-Mercaptopyruvic acid Hydrogen ion + Pyruvic acid + Thiocyanate
Methylisocitric acid > Succinic acid + Pyruvic acid
4-Hydroxy-2-oxopentanoate <> Acetaldehyde + Pyruvic acid
Hydrogen ion + Oxalacetic acid > Pyruvic acid + Carbon dioxide
Pyruvic acid + Adenosine triphosphate <> Hydrogen ion + ADP + Phosphoenolpyruvic acid
Water + Pyruvic acid + Adenosine triphosphate > Hydrogen ion + Phosphate + Phosphoenolpyruvic acid + Adenosine monophosphate
Hydrogen ion + Pyruvic acid + Lipoamide S-Acetyldihydrolipoamide + Carbon dioxide
Pyruvic acid + Coenzyme A + NAD > Acetyl-CoA + Carbon dioxide + NADH
Formic acid + Acetyl-CoA <> Pyruvic acid + Coenzyme A
Pyruvic acid + Water + a ubiquinone > Carbon dioxide + a ubiquinol + Acetic acid
Hydrogen ion + Pyruvic acid + Thiamine pyrophosphate > 2-(a-Hydroxyethyl)thiamine diphosphate + Carbon dioxide
2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate > (1R,6R)-6-Hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + Pyruvic acid
Phosphoenolpyruvic acid + <i>N</i>-acetylmuramate > N-Acetylmuramic acid 6-phosphate + Pyruvic acid
Pyruvic acid + Hydrogen ion > L-Lactic acid
2-keto-3-deoxy-L-rhamnonate Pyruvic acid + Lactaldehyde
Acetic acid + Carbon dioxide + Hydrogen ion <> Pyruvic acid + Water
Phosphoenolpyruvic acid + Salicin > Salicin 6-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + Cellobiose > Cellobiose-6-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + Chitobiose > Pyruvic acid + Diacetylchitobiose-6-phosphate
Phosphoenolpyruvic acid + Mannitol > Sorbitol-6-phosphate + Pyruvic acid
D-fructose + Phosphoenolpyruvic acid > Fructose 1-phosphate + Pyruvic acid
D-fructose + Phosphoenolpyruvic acid > Fructose 6-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + Galactitol > Galactitol 1-phosphate + Pyruvic acid
D-Mannose + Phosphoenolpyruvic acid > Mannose 6-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + N-Acetyl-D-glucosamine > N-Acetyl-D-Glucosamine 6-Phosphate + Pyruvic acid
Glucosamine + Phosphoenolpyruvic acid > Glucosamine 6-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + Trehalose > Trehalose 6-phosphate + Pyruvic acid
Phosphoenolpyruvic acid + Sorbitol > Sorbitol-6-phosphate + Pyruvic acid
L-Tryptophan + Water <> Hydrogen ion + Indole + Pyruvic acid + Ammonia
Pyruvic acid + L-Valine <> L-Alanine + alpha-Ketoisovaleric acid
L-Alanine + Oxoglutaric acid > Pyruvic acid + L-Glutamate
L-Alanine + Oxoglutaric acid > Pyruvic acid + L-Glutamate
4-Hydroxy-2-oxoglutaric acid > Pyruvic acid + Glyoxylic acid
2-Keto-3-deoxy-6-phosphogluconic acid > Pyruvic acid + D-Glyceraldehyde 3-phosphate
L-Valine + Pyruvic acid > a-Ketoisovaleric acid + L-Alanine
L-Aspartate-semialdehyde + Pyruvic acid > (S)-2,3-dihydrodipicolinate +2 Water
D-Cysteine + Water > Hydrogen sulfide + Ammonia + Pyruvic acid
2-Dehydro-3-deoxy-D-galactonate 6-phosphate > Pyruvic acid + D-Glyceraldehyde 3-phosphate
Phosphoenolpyruvic acid + protein L-histidine > Pyruvic acid + protein N(pi)-phospho-L-histidine
D-Lactic acid + NAD > Pyruvic acid + NADH
(R)-Malate + NAD > Pyruvic acid + Carbon dioxide + NADH
2,3-diaminopropionate + Water > Pyruvic acid +2 Ammonia
Pyruvic acid + D-Glyceraldehyde 3-phosphate > 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide
Isochorismate + Water > 2,3-dihydroxy-2,3-dihydrobenzoate + Pyruvic acid
5-Dehydro-4-deoxy-D-glucarate > Pyruvic acid + Tartronate semialdehyde
2-Dehydro-3-deoxy-D-glucarate > Pyruvic acid + Tartronate semialdehyde
4-Hydroxy-2-oxopentanoate > Acetaldehyde + Pyruvic acid
2 Pyruvic acid > 2-Acetolactate + Carbon dioxide
2 Pyruvic acid > 2-Acetolactate + Carbon dioxide
2 Pyruvic acid > 2-Acetolactate + Carbon dioxide
2 Pyruvic acid > 2-Acetolactate + Carbon dioxide
2 Pyruvic acid > 2-Acetolactate + Carbon dioxide
2 Pyruvic acid > 2-Acetolactate + Carbon dioxide
Adenosine triphosphate + Pyruvic acid > ADP + Phosphoenolpyruvic acid
Adenosine triphosphate + Pyruvic acid > ADP + Phosphoenolpyruvic acid
D-Lactic acid + NAD > Pyruvic acid + NADH
L-Lactic acid + 2 Ferricytochrome c > Pyruvic acid +2 Ferrocytochrome c +2 Hydrogen ion
L-Cystathionine + Water > L-Homocysteine + Ammonia + Pyruvic acid
L-Malic acid + NAD > Pyruvic acid + Carbon dioxide + NADH
L-Malic acid + NADP > Pyruvic acid + Carbon dioxide + NADPH
2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate > (1R,6R)-6-Hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + Pyruvic acid
L-Cystathionine + Water > L-Homocysteine + Ammonia + Pyruvic acid
N-acetylneuraminate > N-Acetylmannosamine + Pyruvic acid
Pyruvic acid + CoA + oxidized flavodoxin > Acetyl-CoA + Carbon dioxide + reduced flavodoxin
Pyruvic acid + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine > [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Carbon dioxide
4-Amino-4-deoxychorismate > p-Aminobenzoic acid + Pyruvic acid
Acetyl-CoA + Formic acid > CoA + Pyruvic acid
Acetyl-CoA + Formic acid > CoA + Pyruvic acid
Acetyl-CoA + Formic acid > CoA + Pyruvic acid
Pyruvic acid + Ubiquinone-10 + Water > Acetic acid + Carbon dioxide + Ubiquinol-1
Adenosine triphosphate + Pyruvic acid + Water > Adenosine monophosphate + Phosphoenolpyruvic acid + Inorganic phosphate
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate > Pyruvic acid + Succinic acid
Phosphoenolpyruvic acid + protein L-histidine > Pyruvic acid + protein N(pi)-phospho-L-histidine
Phosphoenolpyruvic acid + protein L-histidine > Pyruvic acid + protein N(pi)-phospho-L-histidine
Phosphoenolpyruvic acid + protein L-histidine > Pyruvic acid + protein N(pi)-phospho-L-histidine
Phosphoenolpyruvic acid + protein L-histidine > Pyruvic acid + protein N(pi)-phospho-L-histidine
2-Dehydro-3-deoxy-L-rhamnonate > Pyruvic acid + D-Lactaldehyde
D-Serine > Pyruvic acid + Ammonia
L-Serine > Pyruvic acid + Ammonia
L-Serine > Pyruvic acid + Ammonia
L-Serine > Pyruvic acid + Ammonia
Acetyl-CoA + Formic acid > CoA + Pyruvic acid
L-Serine > Pyruvic acid + Ammonia
3-Mercaptopyruvic acid + Hydrogen cyanide > Pyruvic acid + Thiocyanate
L-Tryptophan + Water > Indole + Pyruvic acid + Ammonia
Chorismate + L-Glutamine > 2-Aminobenzoic acid + Pyruvic acid + L-Glutamate
Chorismate + L-Glutamine > 2-Aminobenzoic acid + Pyruvic acid + L-Glutamate
Chorismate > 4-Hydroxybenzoic acid + Pyruvic acid
Pyruvic acid + L-Aspartate-semialdehyde <> (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate + Water
L-Cystathionine + Water + 2-Aminoacrylic acid + 2-Iminopropanoate <> L-Homocysteine + Pyruvic acid + Ammonia
L-Serine + 2-Aminoacrylic acid + 2-Iminopropanoate + Water <> Pyruvic acid + Ammonia
D-Serine + 2-Aminoacrylic acid + 2-Iminopropanoate + Water <> Pyruvic acid + Ammonia
Phosphoenolpyruvic acid + Protein histidine <> Pyruvic acid + Protein N(pi)-phospho-L-histidine
2,3-Diaminopropanoate + Water <> Pyruvic acid +2 Ammonia
L-Tryptophan + Water + 2-Aminoacrylic acid + 2-Iminopropanoate <> Indole + Pyruvic acid + Ammonia
L-Malic acid + NAD + Oxalacetic acid <> Pyruvic acid + Carbon dioxide + NADH
L-Malic acid + NADP + Oxalacetic acid <> Pyruvic acid + Carbon dioxide + NADPH
D-Glyceraldehyde 3-phosphate + Pyruvic acid + Hydrogen ion + D-Glyceraldehyde 3-phosphate > 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide + 1-Deoxy-D-xylulose 5-phosphate
Water + isochorismate + Isochorismate > Pyruvic acid + 2,3-dihydroxy-2,3-dihydrobenzoate
L-Aspartate-semialdehyde + Pyruvic acid > Hydrogen ion + Water + (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate
Pyruvic acid + Coenzyme A + NAD > Acetyl-CoA + Carbon dioxide + NADH
Adenosine triphosphate + Pyruvic acid + Hydrogen carbonate > Adenosine diphosphate + Phosphate + Oxalacetic acid + ADP
L-Alanine + Oxoglutaric acid + L-Alanine <> L-Glutamic acid + Pyruvic acid + L-Glutamate
L-Alanine + Glyoxylic acid + L-Alanine <> Glycine + Pyruvic acid
Phosphoenolpyruvic acid + Adenosine monophosphate + Phosphate + 2 Hydrogen ion > Adenosine triphosphate + Water + Pyruvic acid
Water + Adenosine triphosphate + Pyruvic acid > Adenosine monophosphate + Phosphate +2 Hydrogen ion + Phosphoenolpyruvic acid
Phosphoenolpyruvic acid + Adenosine diphosphate + Hydrogen ion + ADP > Adenosine triphosphate + Pyruvic acid
Pyruvic acid + L-Glutamic acid + L-Glutamate > Oxoglutaric acid + L-Alanine + L-Alanine
L-Valine + Pyruvic acid + L-Valine > L-Alanine + a-Ketoisovaleric acid + L-Alanine
D-Alanine + Water + Quinone > Ammonium + Pyruvic acid + Hydroquinone
D-Alanine + Water + an electron-transfer quinone > Ammonium + Pyruvic acid + electron-transfer quinol
5-dehydro-4-deoxy-D-glucarate(2−) > Pyruvic acid + Tartronate semialdehyde
5-dehydro-4-deoxy-D-glucarate(2−) > Pyruvic acid + Tartronate semialdehyde
2 Pyruvic acid + Hydrogen ion > Carbon dioxide + (S)-2-Acetolactate
2 Pyruvic acid + Hydrogen ion > Carbon dioxide + (S)-2-Acetolactate
Chorismate + L-Glutamine > L-Glutamic acid + Pyruvic acid + Hydrogen ion + 2-Aminobenzoic acid + L-Glutamate
2-Ketobutyric acid + Hydrogen ion + Pyruvic acid > Carbon dioxide + 2-Aceto-2-hydroxy-butyrate
L-Malic acid + NADP + L-Malic acid > Carbon dioxide + NADPH + Pyruvic acid + NADPH
L-Malic acid + NAD + L-Malic acid > Carbon dioxide + NADH + Pyruvic acid
2-dehydro-3-deoxy-D-galactonate 6-phosphate + 2-Dehydro-3-deoxy-D-galactonate 6-phosphate > Pyruvic acid + D-Glyceraldehyde 3-phosphate + D-Glyceraldehyde 3-phosphate
L-Lactic acid + oxidized electron acceptor + L-Lactic acid > Reduced acceptor + Pyruvic acid
2-Keto-3-deoxy-6-phosphogluconic acid > D-Glyceraldehyde 3-phosphate + Pyruvic acid + D-Glyceraldehyde 3-phosphate
4-amino-4-deoxychorismate + 4-Amino-4-deoxychorismate > Pyruvic acid + Hydrogen ion + p-Aminobenzoic acid
Methylisocitric acid > Succinic acid + Pyruvic acid
Chorismate > Pyruvic acid + 4-Hydroxybenzoic acid
4-hydroxy-2-oxopentanoate + 4-Hydroxy-2-oxopentanoate > Pyruvic acid + Acetaldehyde
2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate > (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + Pyruvic acid + (1R,6R)-6-Hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
L-Aspartate-semialdehyde + Pyruvic acid <>2 Water + 2,3-Dihydrodipicolinic acid
Pyruvic acid > Carbon dioxide + 2-Acetolactate
L-Lactic acid + oxidized electron acceptor > Pyruvic acid + reduced electron acceptor
D-Glyceraldehyde 3-phosphate + Pyruvic acid + Hydrogen ion > 1-Deoxy-D-xylulose 5-phosphate + Carbon dioxide
Isochorismate + Water > Pyruvic acid + 2,3-dihydroxy-2,3-dihydrobenzoate
N-Acetylneuraminic acid > Pyruvic acid + N-Acetylmannosamine
3-Mercaptopyruvic acid > Pyruvic acid + Hydrogen sulfide
Pyruvic acid + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + Hydrogen ion > a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine + Carbon dioxide
D-Lactic acid + 2 Hydrogen ion + an ubiquinol  > Pyruvic acid + ubiquinone
L-Lactic acid + Ubiquinone-6 > Pyruvic acid + Ubiquinol-6
2 Pyruvic acid + 2 Water > Carbon dioxide + Acetic acid + Hydrogen ion + Electron
More...

SMPDB Pathways:
2,3-dihydroxybenzoate biosynthesisPW000751 Pw000751Pw000751 greyscalePw000751 simple
2-Oxopent-4-enoate metabolismPW001890 Pw001890Pw001890 greyscalePw001890 simple
2-Oxopent-4-enoate metabolism 2PW002035 Pw002035Pw002035 greyscalePw002035 simple
Biosynthesis of siderophore group nonribosomal peptidesPW000760 Pw000760Pw000760 greyscalePw000760 simple
D-Alanine metabolismPW000768 Pw000768Pw000768 greyscalePw000768 simple
D-serine degradationPW002101 Pw002101Pw002101 greyscalePw002101 simple
Enterobactin BiosynthesisPW002048 Pw002048Pw002048 greyscalePw002048 simple
Folate biosynthesisPW000908 Pw000908Pw000908 greyscalePw000908 simple
Galactitol and galactonate degradationPW000820 Pw000820Pw000820 greyscalePw000820 simple
Galactose metabolismPW000821 Pw000821Pw000821 greyscalePw000821 simple
Gluconeogenesis from L-malic acidPW000819 Pw000819Pw000819 greyscalePw000819 simple
Hydrogen Sulfide Biosynthesis IPW002066 Pw002066Pw002066 greyscalePw002066 simple
L-alanine metabolismPW000788 Pw000788Pw000788 greyscalePw000788 simple
L-cysteine degradationPW002110 Pw002110Pw002110 greyscalePw002110 simple
L-lactaldehyde degradation (aerobic)PW002073 Pw002073Pw002073 greyscalePw002073 simple
Lysine biosynthesisPW000771 Pw000771Pw000771 greyscalePw000771 simple
Menaquinol biosythesisPW001897 Pw001897Pw001897 greyscalePw001897 simple
N-acetylneuraminate and N-acetylmannosamine and N-acetylglucosamine degradationPW002030 Pw002030Pw002030 greyscalePw002030 simple
Nitrogen metabolismPW000755 Pw000755Pw000755 greyscalePw000755 simple
Pantothenate and CoA biosynthesisPW000828 Pw000828Pw000828 greyscalePw000828 simple
Phenylalanine metabolismPW000921 Pw000921Pw000921 greyscalePw000921 simple
Propanoate metabolismPW000940 Pw000940Pw000940 greyscalePw000940 simple
S-adenosyl-L-methionine biosynthesisPW000837 Pw000837Pw000837 greyscalePw000837 simple
Secondary Metabolites: Ubiquinol biosynthesisPW000981 Pw000981Pw000981 greyscalePw000981 simple
Secondary Metabolites: Ubiquinol biosynthesis 2PW002036 Pw002036Pw002036 greyscalePw002036 simple
Secondary Metabolites: Valine and I-leucine biosynthesis from pyruvatePW000978 Pw000978Pw000978 greyscalePw000978 simple
Secondary Metabolites: threonine biosynthesis from aspartatePW000976 Pw000976Pw000976 greyscalePw000976 simple
Spermidine Biosynthesis IPW002040 Pw002040Pw002040 greyscalePw002040 simple
Spermidine biosynthesis and metabolismPW002085 Pw002085Pw002085 greyscalePw002085 simple
Sulfur metabolismPW000922 Pw000922Pw000922 greyscalePw000922 simple
Thiazole Biosynthesis IPW002041 Pw002041Pw002041 greyscalePw002041 simple
Tryptophan metabolismPW000815 Pw000815Pw000815 greyscalePw000815 simple
Valine BiosynthesisPW000812 Pw000812Pw000812 greyscalePw000812 simple
Vitamin B6 1430936196PW000891 Pw000891Pw000891 greyscalePw000891 simple
fructose metabolismPW000913 Pw000913Pw000913 greyscalePw000913 simple
fucose and rhamnose degradationPW000826 Pw000826Pw000826 greyscalePw000826 simple
glycerol metabolismPW000914 Pw000914Pw000914 greyscalePw000914 simple
glycerol metabolism IIPW000915 Pw000915Pw000915 greyscalePw000915 simple
glycerol metabolism III (sn-glycero-3-phosphoethanolamine)PW000916 Pw000916Pw000916 greyscalePw000916 simple
glycerol metabolism IV (glycerophosphoglycerol)PW000917 Pw000917Pw000917 greyscalePw000917 simple
glycerol metabolism V (glycerophosphoserine)PW000918 Pw000918Pw000918 greyscalePw000918 simple
glycolysis and pyruvate dehydrogenasePW000785 Pw000785Pw000785 greyscalePw000785 simple
hexuronide and hexuronate degradationPW000834 Pw000834Pw000834 greyscalePw000834 simple
isoleucine biosynthesisPW000818 Pw000818Pw000818 greyscalePw000818 simple
ketogluconate metabolismPW002003 Pw002003Pw002003 greyscalePw002003 simple
methylglyoxal degradation IIPW002084 Pw002084Pw002084 greyscalePw002084 simple
methylglyoxal degradation IVPW002078 Pw002078Pw002078 greyscalePw002078 simple
pyruvate decarboxylation to acetyl CoAPW002083 Pw002083Pw002083 greyscalePw002083 simple
pyruvate to cytochrome bd terminal oxidase electron transferPW002087 Pw002087Pw002087 greyscalePw002087 simple
serine biosynthesis and metabolismPW000809 Pw000809Pw000809 greyscalePw000809 simple
sulfur metabolism (butanesulfonate)PW000923 Pw000923Pw000923 greyscalePw000923 simple
sulfur metabolism (ethanesulfonate)PW000925 Pw000925Pw000925 greyscalePw000925 simple
sulfur metabolism (isethionate)PW000926 Pw000926Pw000926 greyscalePw000926 simple
sulfur metabolism (methanesulfonate)PW000927 Pw000927Pw000927 greyscalePw000927 simple
sulfur metabolism (propanesulfonate)PW000924 Pw000924Pw000924 greyscalePw000924 simple
superpathway of D-glucarate and D-galactarate degradationPW000795 Pw000795Pw000795 greyscalePw000795 simple
tryptophan metabolism IIPW001916 Pw001916Pw001916 greyscalePw001916 simple
KEGG Pathways:
EcoCyc Pathways:
Concentrations
ConcentrationStrainMediaGrowth StatusGrowth SystemTemperatureDetails
8050± 0 uMW31104.0 g/L Na2SO4; 5.36 g/L (NH4)2SO4; 1.0 g/L NH4Cl; 7.3 g/L K2HPO4; 1.8 g/L NaH2PO4 H2O; 12.0 g/L (NH4)2-H-citrate; 4.0 mL/L MgSO4 (1 M); 6.0 mL/L trace element solution; 0.02 g/L thiamine, 20 g/L glucoseMid Log PhaseBioreactor, pH controlled, aerated, dilution rate=0.125 L/h37 oCPark, C., Park, C., Lee, Y., Lee, S.Y., Oh, H.B., Lee, J. (2011) Determination of the Intracellular Concentration of Metabolites in Escherichia coli Collected during the Exponential and Stationary Growth Phases using Liquid Chromatography-Mass Spectrometry. Bull Korean Chem. Soc. 32: 524-530.
900± 0 uMK-12Not AvailableNot AvailableNot AvailableNot Available1. Cybercell Database: http://ccdb.wishartlab.com/CCDB/cgi-bin/STAT_NEW.cgi
2. Phillips R., Kondev, J., Theriot, J. (2008) “Physical Biology of the Cell” Garland Science, New York, NY.
Find out more about how we convert literature concentrations.
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies)splash10-00dr-4900000000-f26ef76666e40ab9fe61View in MoNA
GC-MSGC-MS Spectrum - GC-MS (1 MEOX; 1 TMS)splash10-00di-5900000000-b8e81f82572d4796e944View in MoNA
GC-MSGC-MS Spectrum - GC-MS (2 TMS)splash10-014i-5970000000-154bf9ad168a12593fccView in MoNA
GC-MSGC-MS Spectrum - GC-MSNot Available
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI M-80B) , Positivesplash10-0006-9000000000-a2cf85a5e1d2379d26dfView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-000i-9000000000-dd49835da8355fb6e625View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-000i-9000000000-f09d8e3d7a774b255d89View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-0006-9000000000-7d91f6f626cab1a366fdView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-0006-9000000000-8ae98cdb3e142034e52aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negativesplash10-0006-9000000000-e04e6c68013983e1b6dcView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-0006-9000000000-f315d0752893e7d0c657View in MoNA
1D NMR13C NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
References:
  • Elling D, Bader K: [Biochemical changes in cervix mucus in stepwise malignant transformation of cervix epithelium] Zentralbl Gynakol. 1990;112(9):555-60. Pubmed: 2378186
  • Foster KJ, Alberti KG, Hinks L, Lloyd B, Postle A, Smythe P, Turnell DC, Walton R: Blood intermediary metabolite and insulin concentrations after an overnight fast: reference ranges for adults, and interrelations. Clin Chem. 1978 Sep;24(9):1568-72. Pubmed: 688619
  • Guneral F, Bachmann C: Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. Clin Chem. 1994 Jun;40(6):862-6. Pubmed: 8087979
  • Hoffmann GF, Meier-Augenstein W, Stockler S, Surtees R, Rating D, Nyhan WL: Physiology and pathophysiology of organic acids in cerebrospinal fluid. J Inherit Metab Dis. 1993;16(4):648-69. Pubmed: 8412012
  • Ka T, Yamamoto T, Moriwaki Y, Kaya M, Tsujita J, Takahashi S, Tsutsumi Z, Fukuchi M, Hada T: Effect of exercise and beer on the plasma concentration and urinary excretion of purine bases. J Rheumatol. 2003 May;30(5):1036-42. Pubmed: 12734903
  • Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. Pubmed: 22080510
  • Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. Pubmed: 21097882
  • Meijer-Severs GJ, Van Santen E, Meijer BC: Short-chain fatty acid and organic acid concentrations in feces of healthy human volunteers and their correlations with anaerobe cultural counts during systemic ceftriaxone administration. Scand J Gastroenterol. 1990 Jul;25(7):698-704. Pubmed: 2396083
  • Mongan PD, Capacchione J, West S, Karaian J, Dubois D, Keneally R, Sharma P: Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swine. Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1634-44. Epub 2002 Jun 20. Pubmed: 12234818
  • Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2(1):18. Pubmed: 15882454
  • Nielsen J, Ytrebo LM, Borud O: Lactate and pyruvate concentrations in capillary blood from newborns. Acta Paediatr. 1994 Sep;83(9):920-2. Pubmed: 7819686
  • Park, C., Park, C., Lee, Y., Lee, S.Y., Oh, H.B., Lee, J. (2011) Determination of the Intracellular Concentration of Metabolites in Escherichia coli Collected during the Exponential and Stationary Growth Phases using Liquid Chromatography-Mass Spectrometry. Bull Korean Chem. Soc. 32: 524-530.
  • Reece PA, Cozamanis I, Zacest R: Selective high-performance liquid chromatographic assays for hydralazine and its metabolites in plasma of man. J Chromatogr. 1980 Mar 14;181(3-4):427-40. Pubmed: 7391156
  • Silwood CJ, Lynch E, Claxson AW, Grootveld MC: 1H and (13)C NMR spectroscopic analysis of human saliva. J Dent Res. 2002 Jun;81(6):422-7. Pubmed: 12097436
  • Subramanian A, Gupta A, Saxena S, Gupta A, Kumar R, Nigam A, Kumar R, Mandal SK, Roy R: Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children. NMR Biomed. 2005 Jun;18(4):213-25. Pubmed: 15627241
  • Talseth T, Haegele KD, McNay JL, Skrdlant HB, Clementi WA, Shepherd AM: Pharmacokinetics and cardiovascular effects in rabbits of a major hydralazine metabolite, the hydralazine pyruvic-acid hydrazone. J Pharmacol Exp Ther. 1979 Dec;211(3):509-13. Pubmed: 512915
  • Tsuchiya H, Hashizume I, Tokunaga T, Tatsumi M, Takagi N, Hayashi T: High-performance liquid chromatography of alpha-keto acids in human saliva. Arch Oral Biol. 1983;28(11):989-92. Pubmed: 6581765
  • van der Werf, M. J., Overkamp, K. M., Muilwijk, B., Coulier, L., Hankemeier, T. (2007). "Microbial metabolomics: toward a platform with full metabolome coverage." Anal Biochem 370:17-25. Pubmed: 17765195
  • Vijayendran, C., Barsch, A., Friehs, K., Niehaus, K., Becker, A., Flaschel, E. (2008). "Perceiving molecular evolution processes in Escherichia coli by comprehensive metabolite and gene expression profiling." Genome Biol 9:R72. Pubmed: 18402659
  • Winder, C. L., Dunn, W. B., Schuler, S., Broadhurst, D., Jarvis, R., Stephens, G. M., Goodacre, R. (2008). "Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites." Anal Chem 80:2939-2948. Pubmed: 18331064
  • Zupke C, Sinskey AJ, Stephanopoulos G: Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36. Pubmed: 8579834
Synthesis Reference:Xiang, Wei; Okita, Motomu. Preparation of pyruvic acid. Jpn. Kokai Tokkyo Koho (2003), 5 pp.
Material Safety Data Sheet (MSDS)Download (PDF)
External Links:
ResourceLink
CHEBI ID15361
HMDB IDHMDB00243
Pubchem Compound ID1060
Kegg IDC00022
ChemSpider ID1031
WikipediaPyruvic acid
BioCyc IDPYRUVATE
EcoCyc IDPYRUVATE
Ligand ExpoPYR

Enzymes

General function:
Involved in transporter activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannitol transport
Gene Name:
mtlA
Uniprot ID:
P00550
Molecular weight:
67972
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in magnesium ion binding
Specific function:
2 pyruvate = 2-acetolactate + CO(2)
Gene Name:
ilvI
Uniprot ID:
P00893
Molecular weight:
62984
Reactions
2 pyruvate = 2-acetolactate + CO(2).
General function:
Involved in acetolactate synthase activity
Specific function:
2 pyruvate = 2-acetolactate + CO(2)
Gene Name:
ilvH
Uniprot ID:
P00894
Molecular weight:
17977
Reactions
2 pyruvate = 2-acetolactate + CO(2).
General function:
Involved in biosynthetic process
Specific function:
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
Gene Name:
trpE
Uniprot ID:
P00895
Molecular weight:
57494
Reactions
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
General function:
Involved in anthranilate phosphoribosyltransferase activity
Specific function:
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
Gene Name:
trpD
Uniprot ID:
P00904
Molecular weight:
56869
Reactions
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in D-serine ammonia-lyase activity
Specific function:
D-serine = pyruvate + NH(3)
Gene Name:
dsdA
Uniprot ID:
P00926
Molecular weight:
47900
Reactions
D-serine = pyruvate + NH(3).
General function:
Involved in catalytic activity
Specific function:
Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent
Gene Name:
ilvA
Uniprot ID:
P04968
Molecular weight:
56195
Reactions
L-threonine = 2-oxobutanoate + NH(3).
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucitol/sorbitol transport
Gene Name:
srlB
Uniprot ID:
P05706
Molecular weight:
13304
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
General function:
Involved in flavin adenine dinucleotide binding
Specific function:
First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids
Gene Name:
dld
Uniprot ID:
P06149
Molecular weight:
64612
Reactions
(R)-lactate + NAD(+) = pyruvate + NADH.
General function:
Involved in pyridoxal phosphate binding
Specific function:
L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate
Gene Name:
metC
Uniprot ID:
P06721
Molecular weight:
43212
Reactions
L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate.
General function:
Involved in transferase activity, transferring acyl groups
Specific function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)
Gene Name:
aceF
Uniprot ID:
P06959
Molecular weight:
66096
Reactions
Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.
General function:
Involved in magnesium ion binding
Specific function:
Pyruvate + ferricytochrome b1 + H(2)O = acetate + CO(2) + ferrocytochrome b1
Gene Name:
poxB
Uniprot ID:
P07003
Molecular weight:
62011
Reactions
Pyruvate + ubiquinone + H(2)O = acetate + CO(2) + ubiquinol.
General function:
Involved in magnesium ion binding
Specific function:
2 pyruvate = 2-acetolactate + CO(2)
Gene Name:
ilvB
Uniprot ID:
P08142
Molecular weight:
60440
Reactions
2 pyruvate = 2-acetolactate + CO(2).
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
Acts as both a kinase and a phosphatase on BglG
Gene Name:
bglF
Uniprot ID:
P08722
Molecular weight:
66482
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in transferase activity, transferring phosphorus-containing groups
Specific function:
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Gene Name:
ptsI
Uniprot ID:
P08839
Molecular weight:
63561
Reactions
Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine.
General function:
Involved in transferase activity
Specific function:
L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine
Gene Name:
avtA
Uniprot ID:
P09053
Molecular weight:
46711
Reactions
L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine.
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport
Gene Name:
nagE
Uniprot ID:
P09323
Molecular weight:
68346
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in formate C-acetyltransferase activity
Specific function:
Acetyl-CoA + formate = CoA + pyruvate
Gene Name:
pflB
Uniprot ID:
P09373
Molecular weight:
85357
Reactions
Acetyl-CoA + formate = CoA + pyruvate.
General function:
Involved in D-amino-acid dehydrogenase activity
Specific function:
Oxidative deamination of D-amino acids
Gene Name:
dadA
Uniprot ID:
P0A6J5
Molecular weight:
47607
Reactions
A D-amino acid + H(2)O + acceptor = a 2-oxo acid + NH(3) + reduced acceptor.
General function:
Involved in catalytic activity
Specific function:
L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O
Gene Name:
dapA
Uniprot ID:
P0A6L2
Molecular weight:
31270
Reactions
L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate
Gene Name:
nanA
Uniprot ID:
P0A6L4
Molecular weight:
32593
Reactions
N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.
General function:
Involved in catalytic activity
Specific function:
Interconversion of serine and glycine
Gene Name:
glyA
Uniprot ID:
P0A825
Molecular weight:
45316
Reactions
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
General function:
Involved in lyase activity
Specific function:
L-tryptophan + H(2)O = indole + pyruvate + NH(3)
Gene Name:
tnaA
Uniprot ID:
P0A853
Molecular weight:
52773
Reactions
L-tryptophan + H(2)O = indole + pyruvate + NH(3).
General function:
Involved in catalytic activity
Specific function:
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate
Gene Name:
eda
Uniprot ID:
P0A955
Molecular weight:
22284
Reactions
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate.
General function:
Involved in catalytic activity
Specific function:
Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Gene Name:
pflA
Uniprot ID:
P0A9N4
Molecular weight:
28204
Reactions
S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical.
General function:
Involved in oxidoreductase activity
Specific function:
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes
Gene Name:
lpdA
Uniprot ID:
P0A9P0
Molecular weight:
50688
Reactions
Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
General function:
Involved in 3-hydroxyisobutyrate dehydrogenase activity
Specific function:
(R)-glycerate + NAD(P)(+) = 2-hydroxy-3- oxopropanoate + NAD(P)H
Gene Name:
garR
Uniprot ID:
P0ABQ2
Molecular weight:
30427
Reactions
D-glycerate + NAD(P)(+) = 2-hydroxy-3-oxopropanoate + NAD(P)H.
General function:
Involved in magnesium ion binding
Specific function:
ATP + pyruvate = ADP + phosphoenolpyruvate
Gene Name:
pykF
Uniprot ID:
P0AD61
Molecular weight:
50729
Reactions
ATP + pyruvate = ADP + phosphoenolpyruvate.
General function:
Involved in amino acid binding
Specific function:
2 pyruvate = 2-acetolactate + CO(2)
Gene Name:
ilvN
Uniprot ID:
P0ADF8
Molecular weight:
11106
Reactions
2 pyruvate = 2-acetolactate + CO(2).
General function:
Involved in acetolactate synthase activity
Specific function:
2 pyruvate = 2-acetolactate + CO(2)
Gene Name:
ilvM
Uniprot ID:
P0ADG1
Molecular weight:
9703
Reactions
2 pyruvate = 2-acetolactate + CO(2).
General function:
Involved in isochorismatase activity
Specific function:
Required for production of 2,3-DHB. Also serves as an aryl carrier protein and plays a role in enterobactin assembly
Gene Name:
entB
Uniprot ID:
P0ADI4
Molecular weight:
32554
Reactions
Isochorismate + H(2)O = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate.
General function:
Involved in oxidoreductase activity
Specific function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)
Gene Name:
aceE
Uniprot ID:
P0AFG8
Molecular weight:
99668
Reactions
Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
General function:
Involved in catalytic activity
Specific function:
Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase
Gene Name:
tdcB
Uniprot ID:
P0AGF6
Molecular weight:
35232
Reactions
L-threonine = 2-oxobutanoate + NH(3).
L-serine = pyruvate + NH(3).
General function:
Involved in L-serine ammonia-lyase activity
Specific function:
Deaminates also threonine, particularly when it is present in high concentration
Gene Name:
sdaA
Uniprot ID:
P16095
Molecular weight:
48906
Reactions
L-serine = pyruvate + NH(3).
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
MalX encodes a phosphotransferase system enzyme II that can recognize glucose and maltose as substrates even though these sugars may not represent the natural substrates of the system
Gene Name:
malX
Uniprot ID:
P19642
Molecular weight:
56627
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in sugar:hydrogen symporter activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport
Gene Name:
fruA
Uniprot ID:
P20966
Molecular weight:
57519
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in magnesium ion binding
Specific function:
ATP + pyruvate = ADP + phosphoenolpyruvate
Gene Name:
pykA
Uniprot ID:
P21599
Molecular weight:
51357
Reactions
ATP + pyruvate = ADP + phosphoenolpyruvate.
General function:
Involved in transferase activity
Specific function:
Acts as a beta-cystathionase and as a repressor of the maltose regulon
Gene Name:
malY
Uniprot ID:
P23256
Molecular weight:
43641
Reactions
L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate.
General function:
Involved in carbon-carbon lyase activity
Specific function:
Catalyzes the reversible retro-aldol cleavage of both 5- keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde
Gene Name:
garL
Uniprot ID:
P23522
Molecular weight:
27384
Reactions
5-dehydro-4-deoxy-D-glucarate = pyruvate + tartronate semialdehyde.
2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate
Gene Name:
ppsA
Uniprot ID:
P23538
Molecular weight:
87434
Reactions
ATP + pyruvate + H(2)O = AMP + phosphoenolpyruvate + phosphate.
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in arbutin, cellobiose, and salicin transport
Gene Name:
ascF
Uniprot ID:
P24241
Molecular weight:
51025
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in oxidoreductase activity
Specific function:
Acts on lactaldehyde as well as other aldehydes
Gene Name:
aldA
Uniprot ID:
P25553
Molecular weight:
52272
Reactions
(S)-lactaldehyde + NAD(+) + H(2)O = (S)-lactate + NADH.
Glycolaldehyde + NAD(+) + H(2)O = glycolate + NADH.
General function:
Involved in chorismate lyase activity
Specific function:
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway
Gene Name:
ubiC
Uniprot ID:
P26602
Molecular weight:
18777
Reactions
Chorismate = 4-hydroxybenzoate + pyruvate.
General function:
Involved in oxidoreductase activity
Specific function:
(S)-malate + NAD(+) = pyruvate + CO(2) + NADH
Gene Name:
sfcA
Uniprot ID:
P26616
Molecular weight:
63197
Reactions
(S)-malate + NAD(+) = pyruvate + CO(2) + NADH.
General function:
Involved in 4-amino-4-deoxychorismate lyase activity
Specific function:
Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate
Gene Name:
pabC
Uniprot ID:
P28305
Molecular weight:
29715
Reactions
4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate.
General function:
Involved in L-serine ammonia-lyase activity
Specific function:
Deaminates also threonine, particularly when it is present in high concentration
Gene Name:
sdaB
Uniprot ID:
P30744
Molecular weight:
48753
Reactions
L-serine = pyruvate + NH(3).
General function:
Involved in thiosulfate sulfurtransferase activity
Specific function:
Transfers a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity (130-fold lower). Its participation in detoxification of cyanide may be small. May be involved in the enhancement of serine sensitivity
Gene Name:
sseA
Uniprot ID:
P31142
Molecular weight:
30812
Reactions
3-mercaptopyruvate + cyanide = pyruvate + thiocyanate.
General function:
Involved in transferase activity, transferring phosphorus-containing groups
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane
Gene Name:
ptsA
Uniprot ID:
P32670
Molecular weight:
91773
Reactions
Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine.
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
General function:
Involved in catalytic activity
Specific function:
Acetyl-CoA + formate = CoA + pyruvate
Gene Name:
pflD
Uniprot ID:
P32674
Molecular weight:
85959
Reactions
Acetyl-CoA + formate = CoA + pyruvate.
General function:
Involved in iron-sulfur cluster binding
Specific function:
Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Gene Name:
pflC
Uniprot ID:
P32675
Molecular weight:
32429
Reactions
S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical.
General function:
Involved in catalytic activity
Specific function:
(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+)
Gene Name:
lldD
Uniprot ID:
P33232
Molecular weight:
42728
Reactions
(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+).
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in trehalose transport
Gene Name:
treB
Uniprot ID:
P36672
Molecular weight:
51080
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in protein binding
Specific function:
Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I- Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (ptsO) and EIIA-Ntr (ptsN) proteins
Gene Name:
ptsP
Uniprot ID:
P37177
Molecular weight:
83715
Reactions
Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine.
General function:
Involved in sugar:hydrogen symporter activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in galactitol transport
Gene Name:
gatB
Uniprot ID:
P37188
Molecular weight:
10222
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
Specific function:
Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro
Gene Name:
menH
Uniprot ID:
P37355
Molecular weight:
27682
Reactions
5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.
General function:
Involved in catalytic activity
Specific function:
Specific function unknown
Gene Name:
yjhH
Uniprot ID:
P39359
Molecular weight:
32721
General function:
Involved in L-serine ammonia-lyase activity
Specific function:
L-serine = pyruvate + NH(3)
Gene Name:
tdcG
Uniprot ID:
P42630
Molecular weight:
48521
Reactions
L-serine = pyruvate + NH(3).
General function:
Involved in formate C-acetyltransferase activity
Specific function:
Specific function unknown
Gene Name:
tdcE
Uniprot ID:
P42632
Molecular weight:
85935
Reactions
Propionyl-CoA + formate = CoA + 2-oxobutanoate.
Acetyl-CoA + formate = CoA + pyruvate.
General function:
Involved in 4-hydroxy-2-oxovalerate aldolase activity
Specific function:
Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of 3-phenylpropanoate
Gene Name:
mhpE
Uniprot ID:
P51020
Molecular weight:
36470
Reactions
4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate.
General function:
Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Specific function:
Fermentative lactate dehydrogenase
Gene Name:
ldhA
Uniprot ID:
P52643
Molecular weight:
36535
Reactions
(R)-lactate + NAD(+) = pyruvate + NADH.
General function:
Involved in electron carrier activity
Specific function:
Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (Potential)
Gene Name:
ydbK
Uniprot ID:
P52647
Molecular weight:
128823
Reactions
Pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO(2) + reduced flavodoxin.
General function:
Involved in transporter activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane
Gene Name:
hrsA
Uniprot ID:
P54745
Molecular weight:
69667
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucitol/sorbitol transport
Gene Name:
srlE
Uniprot ID:
P56580
Molecular weight:
33332
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in diaminopropionate ammonia-lyase activity
Specific function:
Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate, the most suitable substrates to form pyruvate and ammonia. The L- and D-isomers of serine are also degraded, though slowly; it is the only serine dehydratase which can eliminate an amino group at the beta-carbon position
Gene Name:
ygeX
Uniprot ID:
P66899
Molecular weight:
43327
Reactions
2,3-diaminopropionate + H(2)O = pyruvate + 2 NH(3).
General function:
Involved in sugar:hydrogen symporter activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport
Gene Name:
crr
Uniprot ID:
P69783
Molecular weight:
18251
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport. This enzyme is also a chemoreceptor monitoring the environment for changes in sugar concentration
Gene Name:
ptsG
Uniprot ID:
P69786
Molecular weight:
50676
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannose transport
Gene Name:
manX
Uniprot ID:
P69797
Molecular weight:
35047
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in transporter activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport
Gene Name:
fruB
Uniprot ID:
P69811
Molecular weight:
39647
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
General function:
Involved in transporter activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport
Gene Name:
ulaC
Uniprot ID:
P69820
Molecular weight:
17237
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
General function:
Involved in sugar:hydrogen symporter activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport
Gene Name:
ulaB
Uniprot ID:
P69822
Molecular weight:
10896
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in transporter activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in galactitol transport
Gene Name:
gatA
Uniprot ID:
P69828
Molecular weight:
16907
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
General function:
Involved in catalytic activity
Specific function:
Unknown Function
Gene Name:
yagE
Uniprot ID:
P75682
Molecular weight:
33316
General function:
Involved in catalytic activity
Specific function:
Acetyl-CoA + formate = CoA + pyruvate
Gene Name:
ybiW
Uniprot ID:
P75793
Molecular weight:
90125
Reactions
Acetyl-CoA + formate = CoA + pyruvate.
General function:
Involved in lyase activity
Specific function:
Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates
Gene Name:
ltaE
Uniprot ID:
P75823
Molecular weight:
36494
Reactions
L-threonine = glycine + acetaldehyde.
L-allo-threonine = glycine + acetaldehyde.
General function:
Involved in magnesium ion binding
Specific function:
Catalyzes the NAD(+)-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D- malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in those conditions. Appears to be not able to use L- tartrate as a substrate for dehydrogenation instead of D-malate
Gene Name:
dmlA
Uniprot ID:
P76251
Molecular weight:
40315
Reactions
(R)-malate + NAD(+) = pyruvate + CO(2) + NADH.
General function:
Involved in D-cysteine desulfhydrase activity
Specific function:
Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine. Can also catalyze the degradation of 3-chloro-D-alanine
Gene Name:
dcyD
Uniprot ID:
P76316
Molecular weight:
35153
Reactions
D-cysteine + H(2)O = H(2)S + NH(3) + pyruvate.
General function:
Involved in carbon-carbon lyase activity
Specific function:
Catalyzes the reversible retro-aldol cleavage of 2-keto- 3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3- deoxy-L-mannonate, 2-keto-3-deoxy-L-lyxonate and 4-hydroxy-2- ketoheptane-1,7-dioate (HKHD) are also reasonably good substrates, although 2-keto-3-deoxy-L-rhamnonate is likely to be the physiological substrate
Gene Name:
rhmA
Uniprot ID:
P76469
Molecular weight:
28916
Reactions
2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (R)-lactaldehyde.
General function:
Involved in oxidoreductase activity
Specific function:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH
Gene Name:
maeB
Uniprot ID:
P76558
Molecular weight:
82417
Reactions
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is responsible for growth on MurNAc as the sole source of carbon and energy. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6- anhydro ring
Gene Name:
murP
Uniprot ID:
P77272
Molecular weight:
49801
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in transferase activity, transferring phosphorus-containing groups
Specific function:
Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). HPr transfers the phosphoryl group to the phosphoryl carrier EIIA, which then transfers it to EIIB
Gene Name:
fryA
Uniprot ID:
P77439
Molecular weight:
92129
Reactions
Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine.
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
General function:
Involved in metabolic process
Specific function:
Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo
Gene Name:
sufS
Uniprot ID:
P77444
Molecular weight:
44433
Reactions
L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.
L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor.
General function:
Involved in 1-deoxy-D-xylulose-5-phosphate synthase activity
Specific function:
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Gene Name:
dxs
Uniprot ID:
P77488
Molecular weight:
67616
Reactions
Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO(2).
General function:
Involved in catalytic activity
Specific function:
Catalyzes the formation of pyruvate and succinate from 2-methylisocitrate
Gene Name:
prpB
Uniprot ID:
P77541
Molecular weight:
32134
Reactions
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
General function:
Involved in thiosulfate sulfurtransferase activity
Specific function:
Thiosulfate + cyanide = sulfite + thiocyanate
Gene Name:
ynjE
Uniprot ID:
P78067
Molecular weight:
48228
Reactions
Thiosulfate + cyanide = sulfite + thiocyanate.
General function:
Involved in catalytic activity
Specific function:
2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate
Gene Name:
dgoA
Uniprot ID:
Q6BF16
Molecular weight:
21390
Reactions
2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate.
General function:
Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active- transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in ascorbate transport
Gene Name:
ulaA
Uniprot ID:
P39301
Molecular weight:
50737
General function:
Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in glucitol/sorbitol transport
Gene Name:
srlA
Uniprot ID:
P56579
Molecular weight:
20580
General function:
Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in mannose transport
Gene Name:
manY
Uniprot ID:
P69801
Molecular weight:
27636
General function:
Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in mannose transport
Gene Name:
manZ
Uniprot ID:
P69805
Molecular weight:
31303
General function:
Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in galactitol transport
Gene Name:
gatC
Uniprot ID:
P69831
Molecular weight:
48365
General function:
Energy production and conversion
Specific function:
Specific function unknown
Gene Name:
ykgE
Uniprot ID:
P77252
Molecular weight:
26004
General function:
Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:
Specific function unknown
Gene Name:
yfbQ
Uniprot ID:
P0A959
Molecular weight:
45517
Reactions
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.
General function:
Involved in FMN binding
Specific function:
Low-potential electron donor to a number of redox enzymes (Potential)
Gene Name:
fldB
Uniprot ID:
P0ABY4
Molecular weight:
19700
General function:
Involved in FMN binding
Specific function:
Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase
Gene Name:
fldA
Uniprot ID:
P61949
Molecular weight:
19737
General function:
Involved in glycerone kinase activity
Specific function:
Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of dhaR by binding to its sensor domain, in the absence of dihydroxyacetone
Gene Name:
dhaK
Uniprot ID:
P76015
Molecular weight:
38215
General function:
Unknown function
Specific function:
Specific function unknown
Gene Name:
ykgG
Uniprot ID:
P77433
Molecular weight:
25212
General function:
Involved in lactate oxidation
Specific function:
Specific function unknown
Gene Name:
ykgF
Uniprot ID:
P77536
Molecular weight:
53052
General function:
Involved in glycerone kinase activity
Specific function:
ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaL- ADP receives a phosphoryl group from dhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sensor domain of dhaR. DhaL-ATP is inactive
Gene Name:
dhaL
Uniprot ID:
P76014
Molecular weight:
22632
General function:
Involved in transferase activity, transferring phosphorus-containing groups
Specific function:
Phosphotransferase subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaM serves as the phosphoryl donor. It is phosphorylated by HPr, then it donates its phosphoryl group to dhaL-ADP, which eventually transmits it to dihydroxyacetone
Gene Name:
dhaM
Uniprot ID:
P37349
Molecular weight:
51448
Reactions
Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine.
Protein HPr N(pi)-phospho-L-histidine + protein EIIA = protein HPr + protein EIIA N(tau)-phospho-L-histidine.
Protein EIIA N(pi)-phospho-L-histidine + dhaL-ADP = protein EIIA + dhaL-ATP.
General function:
Involved in sugar:hydrogen symporter activity
Specific function:
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III)
Gene Name:
ptsH
Uniprot ID:
P0AA04
Molecular weight:
9119
Reactions
Protein HPr N(pi)-phospho-L-histidine + protein EIIA = protein HPr + protein EIIA N(tau)-phospho-L-histidine.
General function:
Involved in catalytic activity
Specific function:
Acts as a radical domain for damaged PFL and possibly other radical proteins
Gene Name:
grcA
Uniprot ID:
P68066
Molecular weight:
14284
General function:
Amino acid transport and metabolism
Specific function:
Specific function unknown
Gene Name:
yfdZ
Uniprot ID:
P77434
Molecular weight:
46216
Reactions
L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Transporters

General function:
Involved in transporter activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannitol transport
Gene Name:
mtlA
Uniprot ID:
P00550
Molecular weight:
67972
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
Acts as both a kinase and a phosphatase on BglG
Gene Name:
bglF
Uniprot ID:
P08722
Molecular weight:
66482
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport
Gene Name:
nagE
Uniprot ID:
P09323
Molecular weight:
68346
Reactions
Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
MalX encodes a phosphotransferase system enzyme II that can recognize glucose and maltose as substrates even though these sugars may not represent the natural substrates of the system
Gene Name:
malX
Uniprot ID:
P19642
Molecular weight:
56627
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in sugar:hydrogen symporter activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport
Gene Name:
fruA
Uniprot ID:
P20966
Molecular weight:
57519
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in arbutin, cellobiose, and salicin transport
Gene Name:
ascF
Uniprot ID:
P24241
Molecular weight:
51025
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in trehalose transport
Gene Name:
treB
Uniprot ID:
P36672
Molecular weight:
51080
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport. This enzyme is also a chemoreceptor monitoring the environment for changes in sugar concentration
Gene Name:
ptsG
Uniprot ID:
P69786
Molecular weight:
50676
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is responsible for growth on MurNAc as the sole source of carbon and energy. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6- anhydro ring
Gene Name:
murP
Uniprot ID:
P77272
Molecular weight:
49801
Reactions
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
General function:
Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active- transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in ascorbate transport
Gene Name:
ulaA
Uniprot ID:
P39301
Molecular weight:
50737
General function:
Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in glucitol/sorbitol transport
Gene Name:
srlA
Uniprot ID:
P56579
Molecular weight:
20580
General function:
Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in mannose transport
Gene Name:
manY
Uniprot ID:
P69801
Molecular weight:
27636
General function:
Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in mannose transport
Gene Name:
manZ
Uniprot ID:
P69805
Molecular weight:
31303
General function:
Involved in phosphoenolpyruvate-dependent sugar phosphotransferase system
Specific function:
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in galactitol transport
Gene Name:
gatC
Uniprot ID:
P69831
Molecular weight:
48365
General function:
Involved in transporter activity
Specific function:
Non-specific porin
Gene Name:
ompN
Uniprot ID:
P77747
Molecular weight:
41220
General function:
Involved in transporter activity
Specific function:
Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
Gene Name:
phoE
Uniprot ID:
P02932
Molecular weight:
38922
General function:
Involved in transporter activity
Specific function:
OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
Gene Name:
ompF
Uniprot ID:
P02931
Molecular weight:
39333
General function:
Involved in transporter activity
Specific function:
Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
Gene Name:
ompC
Uniprot ID:
P06996
Molecular weight:
40368