Record Information
Version2.0
Creation Date2012-05-31 10:24:17 -0600
Update Date2015-09-13 12:56:07 -0600
Secondary Accession Numbers
  • ECMDB00229
Identification
Name:Nicotinamide ribotide
Description:Nicotinamide ribotide (NMN) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Nicotinamide is directly converted to NMN by nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12). The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1), a member of the nucleotidyltransferase alpha/beta-phosphodiesterase superfamily, catalyzes the reaction NMN + ATP = Nicotinamide adenine dinucleotide (NAD) + PPi, representing the final step in the biosynthesis of NAD, a molecule playing a fundamental role as a cofactor in cellular redox reactions. Thus NMN is an important metabolite for the maintenance of normal NAD biosynthesis, and circulating NMN levels may play an important role in regulating cell function in physiological and pathophysiological conditions. (PMID: 15078171, 17983582)
Structure
Thumb
Synonyms:
  • β-nicotinamide mononucleotide
  • β-nicotinamide nucleotide
  • β-nicotinamide ribonucleotide
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium hydroxide inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-b-delta-ribofuranosyl)-pyridinium hydroxide inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-b-delta-ribofuranosyl)-pyridinium inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-b-δ-ribofuranosyl)-pyridinium hydroxide inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-b-δ-ribofuranosyl)-pyridinium inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium hydroxide inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-β-δ-ribofuranosyl)-pyridinium hydroxide inner salt
  • 3-(Aminocarbonyl)-1-(5-O-phosphono-β-δ-ribofuranosyl)-pyridinium inner salt
  • 3-Carbamoyl-1-b-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carbamoyl-1-b-D-ribofuranosylpyridinium hydroxide 5'-phosphoric acid inner salt
  • 3-Carbamoyl-1-b-delta-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carbamoyl-1-b-delta-ribofuranosylpyridinium hydroxide 5'-phosphoric acid inner salt
  • 3-Carbamoyl-1-b-δ-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carbamoyl-1-b-δ-ribofuranosylpyridinium hydroxide 5'-phosphoric acid inner salt
  • 3-Carbamoyl-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carbamoyl-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-phosphoric acid inner salt
  • 3-Carbamoyl-1-β-δ-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carbamoyl-1-β-δ-ribofuranosylpyridinium hydroxide 5'-phosphoric acid inner salt
  • 3-Carboxy-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-b-delta-ribofuranosyl)-pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-b-δ-ribofuranosyl)-pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-β-D-ribofuranosyl)-pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-β-δ-ribofuranosyl)-pyridinium inner salt
  • 3-Carboxy-1-b-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-b-D-ribofuranosylpyridinium hydroxide 5'-phosphoric acid inner salt
  • 3-Carboxy-1-b-delta-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-b-delta-ribofuranosylpyridinium hydroxide 5'-phosphoric acid inner salt
  • 3-Carboxy-1-b-δ-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-b-δ-ribofuranosylpyridinium hydroxide 5'-phosphoric acid inner salt
  • 3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphoric acid inner salt
  • 3-Carboxy-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-phosphoric acid inner salt
  • 3-Carboxy-1-β-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-β-D-ribofuranosylpyridinium hydroxide 5'-phosphoric acid inner salt
  • 3-Carboxy-1-β-δ-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-β-δ-ribofuranosylpyridinium hydroxide 5'-phosphoric acid inner salt
  • 3-Pyridinecarboxylate mononucleotide
  • 3-Pyridinecarboxylic acid mononucleotide
  • B-D-NMN
  • b-delta-NMN
  • b-Nicotinamide mononucleotide
  • b-Nicotinamide nucleotide
  • b-Nicotinamide ribonucleotide
  • b-Nicotinamide-D-ribonucleotide
  • b-Nicotinate D-ribonucleotide
  • b-Nicotinate mononucleotide
  • b-Nicotinate-D-nucleotide
  • b-Nicotinic acid D-ribonucleotide
  • b-Nicotinic acid mononucleotide
  • b-Nicotinic acid-D-nucleotide
  • B-NMN
  • b-δ-NMN
  • Beta-delta-NMN
  • Beta-Nicotinamide mononucleotide
  • Beta-Nicotinamide nucleotide
  • Beta-Nicotinamide ribonucleotide
  • Beta-Nicotinamide-D-ribonucleotide
  • Beta-Nicotinate D-ribonucleotide
  • Beta-Nicotinate mononucleotide
  • Beta-Nicotinate-D-nucleotide
  • Beta-Nicotinic acid D-ribonucleotide
  • Beta-Nicotinic acid mononucleotide
  • beta-Nicotinic acid-D-nucleotide
  • Beta-NMN
  • Deamido nicotinamide ribonucleotide
  • Deamido-nicotinamide mononucleotide
  • Deamido-NMN
  • NaMN
  • Nicotinamide D-ribonucleotide
  • Nicotinamide mononucleotide
  • Nicotinamide ribonucleoside 5'-phosphate
  • Nicotinamide ribonucleoside 5'-phosphoric acid
  • Nicotinamide ribonucleotide
  • Nicotinate D-ribonucleoside
  • Nicotinate D-ribonucleotide
  • Nicotinate dinucleotide
  • Nicotinate mononucleotide
  • Nicotinate nucleotide
  • Nicotinate ribonucleotide
  • Nicotinate ribotide
  • Nicotinate-D-ribonucleotide
  • Nicotinate-delta-ribonucleotide
  • Nicotinate-δ-ribonucleotide
  • Nicotinic acid D-ribonucleoside
  • Nicotinic acid D-ribonucleotide
  • Nicotinic acid dinucleotide
  • Nicotinic acid mononucleotide
  • Nicotinic acid nucleotide
  • Nicotinic acid ribonucleotide
  • Nicotinic acid ribotide
  • Nicotinic acid-D-ribonucleotide
  • Nicotinic acid-delta-ribonucleotide
  • Nicotinic acid-δ-ribonucleotide
  • Nicotinic mononucleotide
  • NMN
  • β-Nicotinamide mononucleotide
  • β-Nicotinamide nucleotide
  • β-Nicotinamide ribonucleotide
  • β-Nicotinamide-D-ribonucleotide
  • β-Nicotinate D-ribonucleotide
  • β-Nicotinate mononucleotide
  • β-Nicotinate-D-nucleotide
  • β-Nicotinic acid D-ribonucleotide
  • β-Nicotinic acid mononucleotide
  • β-Nicotinic acid-D-nucleotide
  • β-NMN
  • β-δ-NMN
Chemical Formula:C11H15NO9P
Weight:Average: 336.2119
Monoisotopic: 336.048442595
InChI Key:JOUIQRNQJGXQDC-ZYUZMQFOSA-O
InChI:InChI=1S/C11H14NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H2-,15,16,17,18,19)/p+1/t7-,8-,9-,10-/m1/s1
CAS number:1094-61-7
IUPAC Name:3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1λ⁵-pyridin-1-ylium
Traditional IUPAC Name:NaMN
SMILES:O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)[N+]1=CC=CC(=C1)C(O)=O
Chemical Taxonomy
Description belongs to the class of organic compounds known as nicotinic acid nucleotides. These are pyridine nucleotides, in which the pyridine base is nicotinic acid or a derivative thereof.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
ClassPyridine nucleotides
Sub ClassNicotinic acid nucleotides
Direct ParentNicotinic acid nucleotides
Alternative Parents
Substituents
  • Nicotinic-acid-nucleotide
  • Pentose phosphate
  • Pentose-5-phosphate
  • Glycosyl compound
  • N-glycosyl compound
  • Monosaccharide phosphate
  • Pentose monosaccharide
  • Pyridine carboxylic acid
  • Pyridine carboxylic acid or derivatives
  • Monoalkyl phosphate
  • Monosaccharide
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Pyridine
  • Pyridinium
  • Alkyl phosphate
  • Vinylogous amide
  • Tetrahydrofuran
  • Heteroaromatic compound
  • Secondary alcohol
  • 1,2-diol
  • Carboxylic acid derivative
  • Organoheterocyclic compound
  • Azacycle
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Oxacycle
  • Organopnictogen compound
  • Organic nitrogen compound
  • Organic oxygen compound
  • Organic oxide
  • Alcohol
  • Organonitrogen compound
  • Organooxygen compound
  • Hydrocarbon derivative
  • Organic cation
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Physical Properties
State:Solid
Charge:-2
Melting point:Not Available
Experimental Properties:
PropertyValueSource
Predicted Properties
PropertyValueSource
Water Solubility1.71 g/LALOGPS
logP-0.99ALOGPS
logP-5.4ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)1.2ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area157.63 ŲChemAxon
Rotatable Bond Count5ChemAxon
Refractivity69.89 m³·mol⁻¹ChemAxon
Polarizability28.66 ųChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Cytoplasm
Reactions:
Water + NAD <> Adenosine monophosphate +2 Hydrogen ion + Nicotinamide ribotide + NMN
Adenosine triphosphate + Hydrogen ion + Nicotinamide ribotide + NMN <> NAD + Pyrophosphate
2 Hydrogen ion + Phosphoribosyl pyrophosphate + Quinolinic acid <> Carbon dioxide + Nicotinamide ribotide + Pyrophosphate
Adenosine triphosphate + Hydrogen ion + Nicotinamide ribotide <> Nicotinic acid adenine dinucleotide + Pyrophosphate
Adenosine triphosphate + Water + Nicotinic acid + Phosphoribosyl pyrophosphate > ADP + Nicotinamide ribotide + Phosphate + Pyrophosphate
Dimethylbenzimidazole + Nicotinamide ribotide <> N1-(5-Phospho-a-D-ribosyl)-5,6-dimethylbenzimidazole + Hydrogen ion + Nicotinic acid
NAD + Water <> Adenosine monophosphate + Nicotinamide ribotide
Adenosine triphosphate + Nicotinamide ribotide <> Pyrophosphate + NAD
Nicotinamide ribotide + Pyrophosphate + Adenosine triphosphate + Water <> Nicotinic acid + Phosphoribosyl pyrophosphate + ADP + Phosphate
Nicotinamide ribotide + Water <> Nicotinamide riboside + Phosphate
Nicotinic acid adenine dinucleotide + Water <> Adenosine monophosphate + Nicotinamide ribotide
Adenosine triphosphate + Nicotinamide ribotide <> Pyrophosphate + Nicotinic acid adenine dinucleotide
Nicotinamide ribotide + Water <> Nicotinate D-ribonucleoside + Phosphate
Nicotinamide ribotide + Pyrophosphate + Carbon dioxide <> Quinolinic acid + Phosphoribosyl pyrophosphate
Nicotinamide ribotide + Dimethylbenzimidazole <> Nicotinic acid + N1-(5-Phospho-a-D-ribosyl)-5,6-dimethylbenzimidazole + Hydrogen ion
Hydrogen ion + Nicotinamide ribotide + Adenosine triphosphate <> NAD + Pyrophosphate
Nicotinamide ribotide + Dimethylbenzimidazole > Hydrogen ion + Nicotinic acid + N1-(5-Phospho-a-D-ribosyl)-5,6-dimethylbenzimidazole
DNA<sub><i>n</i></sub> + (deoxynucleotides)<sub>(m)</sub> + NAD > (deoxynucleotides)<sub>(m)</sub> + Nicotinamide ribotide + Adenosine monophosphate
Water + NAD > Hydrogen ion + Nicotinamide ribotide + Adenosine monophosphate
Hydrogen ion + Adenosine triphosphate + Nicotinamide ribotide > Pyrophosphate + Nicotinic acid adenine dinucleotide
Nicotinamide ribotide + Pyrophosphate < Hydrogen ion + Nicotinic acid + Phosphoribosyl pyrophosphate
Nicotinamide ribotide + Water > Hydrogen ion + Nicotinamide ribotide + Ammonia
Nicotinamide ribotide + Water > Hydrogen ion + Nicotinamide ribotide + Ammonia
Water + Nicotinamide ribotide <> Hydrogen ion + D-Ribose-5-phosphate + Niacinamide
Nicotinamide ribotide + Pyrophosphate + Carbon dioxide < Phosphoribosyl pyrophosphate + Quinolinic acid + Hydrogen ion

SMPDB Pathways:
NAD biosynthesisPW000829 ThumbThumb?image type=greyscaleThumb?image type=simple
NAD salvagePW000830 ThumbThumb?image type=greyscaleThumb?image type=simple
adenosylcobalamin salvage from cobinamidePW001884 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways:
EcoCyc Pathways:
Concentrations
Not Available
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-00kb-9704000000-b4f3d91df4a5fb88cc5eView in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (3 TMS) - 70eV, Positivesplash10-000b-9221310000-f2425a1cc55147b91d2bView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-1009000000-227e6a4729b96a705fa4View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-002b-5239000000-223d08e3fd97af58d374View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0007-9500000000-db23a80f58b7ac9781fdView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-000i-1009000000-f16974a59d3ff46358d6View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-002b-9001000000-ca67d776dd7d3f5d4650View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9000000000-5808f9bb378f2d60cd9bView in MoNA
References
References:
  • Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. Pubmed: 22080510
  • Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. Pubmed: 21097882
  • Magni, G., Amici, A., Emanuelli, M., Orsomando, G., Raffaelli, N., Ruggieri, S. (2004). "Structure and function of nicotinamide mononucleotide adenylyltransferase." Curr Med Chem 11:873-885. Pubmed: 15078171
  • van der Werf, M. J., Overkamp, K. M., Muilwijk, B., Coulier, L., Hankemeier, T. (2007). "Microbial metabolomics: toward a platform with full metabolome coverage." Anal Biochem 370:17-25. Pubmed: 17765195
Synthesis Reference:Liu, Rihe; Visscher, Johannes. A novel preparation of nicotinamide mononucleotide. Nucleosides & Nucleotides (1994), 13(5), 1215-16.
Material Safety Data Sheet (MSDS)Download (PDF)
External Links:
ResourceLink
CHEBI ID16171
HMDB IDHMDB00229
Pubchem Compound ID14180
Kegg IDC01185
ChemSpider ID13553
Wikipedia IDNot Available
BioCyc IDNICOTINAMIDE_NUCLEOTIDE
EcoCyc IDNICOTINAMIDE_NUCLEOTIDE
Ligand ExpoNCN

Enzymes

General function:
Involved in hydrolase activity
Specific function:
Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell
Gene Name:
ushA
Uniprot ID:
P07024
Molecular weight:
60824
Reactions
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Gene Name:
nadD
Uniprot ID:
P0A752
Molecular weight:
24528
Reactions
ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+).
General function:
Involved in hydrolase activity
Specific function:
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth phase
Gene Name:
surE
Uniprot ID:
P0A840
Molecular weight:
26900
Reactions
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
A 3'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
(Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate.
General function:
Involved in catalytic activity
Specific function:
Nucleotidase that shows high phosphatase activity toward three nucleoside 5'-monophosphates, UMP, dUMP, and dTMP, and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Is strictly specific to substrates with 5'- phosphates and shows no activity against nucleoside 2'- or 3'- monophosphates. Might be involved in the pyrimidine nucleotide substrate cycles
Gene Name:
yjjG
Uniprot ID:
P0A8Y1
Molecular weight:
25300
Reactions
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
General function:
Involved in DNA ligase (NAD+) activity
Specific function:
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Gene Name:
ligA
Uniprot ID:
P15042
Molecular weight:
73605
Reactions
NAD(+) + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)(n+m).
General function:
Involved in nicotinate phosphoribosyltransferase activity
Specific function:
Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate
Gene Name:
pncB
Uniprot ID:
P18133
Molecular weight:
45897
Reactions
Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in DNA ligase (NAD+) activity
Specific function:
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction
Gene Name:
ligB
Uniprot ID:
P25772
Molecular weight:
63179
Reactions
NAD(+) + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)(n+m).
General function:
Involved in negative regulation of transcription, DNA-dependent
Specific function:
NadR is bifunctional; it interacts with pnuC at low internal NAD levels, permitting transport of NMN intact into the cell. As NAD levels increase within the cell, the affinity of nadR for the operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes
Gene Name:
nadR
Uniprot ID:
P27278
Molecular weight:
47346
Reactions
ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).
ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide.
General function:
Involved in catalytic activity
Specific function:
Involved in the catabolism of quinolinic acid (QA)
Gene Name:
nadC
Uniprot ID:
P30011
Molecular weight:
32762
Reactions
Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in hydrolase activity
Specific function:
NAD(+) + H(2)O = AMP + NMN
Gene Name:
nudC
Uniprot ID:
P32664
Molecular weight:
29689
Reactions
NAD(+) + H(2)O = AMP + NMN.
General function:
Involved in nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Specific function:
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)
Gene Name:
cobT
Uniprot ID:
P36562
Molecular weight:
36987
Reactions
Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.
General function:
Involved in catalytic activity
Specific function:
Nucleotidase that shows strict specificity toward deoxyribonucleoside 5'-monophosphates and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'-monophosphates. Might be involved in the regulation of all dNTP pools in E.coli
Gene Name:
yfbR
Uniprot ID:
P76491
Molecular weight:
22708
Reactions
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
General function:
pyridine nucleotide biosynthetic process
Specific function:
Has nicotinamidemononucleotide (NMN) aminohydrolase activity, not active on other substrates.
Gene Name:
pncC
Uniprot ID:
P0A6G3
Molecular weight:
17581
Reactions
Beta-nicotinamide D-ribonucleotide + H(2)O = beta-nicotinate D-ribonucleotide + NH(3)

Transporters

General function:
Involved in transport
Specific function:
Required for nicotinamide riboside transport across the inner membrane
Gene Name:
pnuC
Uniprot ID:
P0AFK2
Molecular weight:
26996
General function:
Involved in transporter activity
Specific function:
Non-specific porin
Gene Name:
ompN
Uniprot ID:
P77747
Molecular weight:
41220
General function:
Involved in transporter activity
Specific function:
Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
Gene Name:
phoE
Uniprot ID:
P02932
Molecular weight:
38922
General function:
Involved in transporter activity
Specific function:
OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
Gene Name:
ompF
Uniprot ID:
P02931
Molecular weight:
39333
General function:
Involved in transporter activity
Specific function:
Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
Gene Name:
ompC
Uniprot ID:
P06996
Molecular weight:
40368