Record Information
Version2.0
Creation Date2012-07-30 14:55:41 -0600
Update Date2015-09-13 15:15:32 -0600
Secondary Accession Numbers
  • ECMDB21391
Identification
Name:Nickel
Description:Nickel is a solid, silver-white, hard, malleable transition metal with an atomic number of 28. It resists corrosion even at high temperatures. It is present in many alloys in widespread use, including stainless steels. It may also be present as an impurity in any alloy. Nickel is used in the production of coins, jewellery, and nickel-cadmium batteries, and as a catalyst for the hydrogenation of liquid oils to solid fats such as oleomargarine and vegetable shortening. Nickel-containing dental alloys continue to be used successfully in the provision of various forms of dental care. Many of these alloys have applications in the construction of restorations designed to remain in clinical service for many years, including crowns, fixed bridgework, and removable partial dentures. Furthermore, nickel containing alloys find extensive application in orthodontics, including metallic brackets, arch wires, bands, springs and ligature wires. Many instruments and devises, for example, endodontic instruments also contain nickel.
Structure
Thumb
Synonyms:
  • Carbonyl nickel powder
  • Malleable nickel
  • NI
  • Ni(2+)
  • Ni(II)
  • Ni++
  • Ni2+
  • Nichel
  • NICKEL (II) ION
  • Nickel 200
  • Nickel 201
  • Nickel 204
  • Nickel 205
  • Nickel 211
  • Nickel 212
  • Nickel 213
  • Nickel 222
  • Nickel 223
  • Nickel 229
  • Nickel 270
  • Nickel particles
  • Nickel sponge
  • Nickel(2+)
  • Nickel, ion (Ni2+)
  • Nickelous ion
  • Raney alloy
  • Raney nickel
Chemical Formula:Ni
Weight:Average: 58.6934
Monoisotopic: 57.935347922
InChI Key:VEQPNABPJHWNSG-UHFFFAOYSA-N
InChI:InChI=1S/Ni/q+2
CAS number:7440-02-0
IUPAC Name:nickel(2+) ion
Traditional IUPAC Name:nickel(2+) ion
SMILES:[Ni++]
Chemical Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
KingdomChemical entities
Super ClassInorganic compounds
ClassHomogeneous metal compounds
Sub ClassHomogeneous transition metal compounds
Direct ParentHomogeneous transition metal compounds
Alternative Parents
Substituents
  • Homogeneous transition metal
  • Inorganic nickel compound
Molecular FrameworkNot Available
External Descriptors
Physical Properties
State:Solid
Charge:2
Melting point:1455 °C
Experimental Properties:
PropertyValueSource
Predicted Properties
PropertyValueSource
logP0.16ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Cytoplasm
Reactions:
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
EcoCyc Pathways:Not Available
Concentrations
Not Available
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0a4i-9000000000-08256b3c9e2cc1750f60View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0a4i-9000000000-08256b3c9e2cc1750f60View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4i-9000000000-08256b3c9e2cc1750f60View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0a4i-9000000000-4648ffc6f53552c41503View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0a4i-9000000000-4648ffc6f53552c41503View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a4i-9000000000-4648ffc6f53552c41503View in MoNA
References
References:
  • Biego GH, Joyeux M, Hartemann P, Debry G: Daily intake of essential minerals and metallic micropollutants from foods in France. Sci Total Environ. 1998 Jun 30;217(1-2):27-36. Pubmed: 9695171
  • Hostynek JJ: Sensitization to nickel: etiology, epidemiology, immune reactions, prevention, and therapy. Rev Environ Health. 2006 Oct-Dec;21(4):253-80. Pubmed: 17243350
  • Nielsen FH: How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? J Nutr. 1996 Sep;126(9 Suppl):2377S-2385S. Pubmed: 8811801
  • Setcos JC, Babaei-Mahani A, Silvio LD, Mjor IA, Wilson NH: The safety of nickel containing dental alloys. Dent Mater. 2006 Dec;22(12):1163-8. Epub 2006 Jan 6. Pubmed: 16405986
  • Uthus EO, Seaborn CD: Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements. J Nutr. 1996 Sep;126(9 Suppl):2452S-2459S. Pubmed: 8811811
Synthesis Reference:Lightner, David A.; Crist, B. Vincent; Kalyanam, Nagabushanam; May, Leslie M.; Jackman, Dennis E. The octant rule. 15. Antioctant effects: synthesis and circular dichroism of 2-exo- and 2-endo-alkylbicyclo[2.2.1]heptan-7-ones and bicyclo[3.2.1]octan-8-one
Material Safety Data Sheet (MSDS)Not Available
External Links:
ResourceLink
CHEBI ID28112
HMDB IDHMDB02457
Pubchem Compound ID935
Kegg IDC00291
ChemSpider ID909
WikipediaNickel
BioCyc IDNI%2b2
EcoCyc IDNI%2b2
Ligand ExpoNI

Enzymes

General function:
Involved in hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Specific function:
Mediates magnesium influx to the cytosol
Gene Name:
mgtA
Uniprot ID:
P0ABB8
Molecular weight:
99466
Reactions
ATP + H(2)O + Mg(2+)(Out) = ADP + phosphate + Mg(2+)(In).
General function:
Involved in nucleotide binding
Specific function:
Involved in export of lead, cadmium, zinc and mercury
Gene Name:
zntA
Uniprot ID:
P37617
Molecular weight:
76839
Reactions
ATP + H(2)O + Cd(2+)(In) = ADP + phosphate + Cd(2+)(Out).
ATP + H(2)O + Zn(2+)(In) = ADP + phosphate + Zn(2+)(Out).
General function:
Involved in transporter activity
Specific function:
Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane
Gene Name:
nikC
Uniprot ID:
P0AFA9
Molecular weight:
30362
General function:
Involved in transporter activity
Specific function:
Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane
Gene Name:
nikB
Uniprot ID:
P33591
Molecular weight:
35248
General function:
Involved in transporter activity
Specific function:
Involved in a nickel transport system, probably represents the nickel binder
Gene Name:
nikA
Uniprot ID:
P33590
Molecular weight:
58718
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
Gene Name:
nikD
Uniprot ID:
P33593
Molecular weight:
26820
Reactions
ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In).
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
Gene Name:
nikE
Uniprot ID:
P33594
Molecular weight:
29721
Reactions
ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In).

Transporters

General function:
Involved in transporter activity
Specific function:
Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane
Gene Name:
nikC
Uniprot ID:
P0AFA9
Molecular weight:
30362
General function:
Involved in transporter activity
Specific function:
Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane
Gene Name:
nikB
Uniprot ID:
P33591
Molecular weight:
35248
General function:
Involved in cation transmembrane transporter activity
Specific function:
Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas zntA is required for growth at more toxic concentrations
Gene Name:
zitB
Uniprot ID:
P75757
Molecular weight:
34678
General function:
Involved in transporter activity
Specific function:
Involved in a nickel transport system, probably represents the nickel binder
Gene Name:
nikA
Uniprot ID:
P33590
Molecular weight:
58718
General function:
Involved in transporter activity
Specific function:
Non-specific porin
Gene Name:
ompN
Uniprot ID:
P77747
Molecular weight:
41220
General function:
Involved in cation transmembrane transporter activity
Specific function:
Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton- dependent manner
Gene Name:
fieF
Uniprot ID:
P69380
Molecular weight:
32927
General function:
Involved in transporter activity
Specific function:
Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
Gene Name:
phoE
Uniprot ID:
P02932
Molecular weight:
38922
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
Gene Name:
nikD
Uniprot ID:
P33593
Molecular weight:
26820
Reactions
ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In).
General function:
Involved in transporter activity
Specific function:
OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
Gene Name:
ompF
Uniprot ID:
P02931
Molecular weight:
39333
General function:
Involved in cobalt ion transmembrane transporter activity
Specific function:
Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake
Gene Name:
corA
Uniprot ID:
P0ABI4
Molecular weight:
36589
General function:
Involved in nucleotide binding
Specific function:
Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system
Gene Name:
nikE
Uniprot ID:
P33594
Molecular weight:
29721
Reactions
ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In).
General function:
Involved in transporter activity
Specific function:
Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
Gene Name:
ompC
Uniprot ID:
P06996
Molecular weight:
40368