2.02012-05-31 14:49:43 -06002015-09-18 09:17:43 -0600ECMDB20540M2MDB001347D-Allulose-6-phosphateD-allulose-6-phosphate is a hexose phosphate. Hexoses are monosaccharides in which the sugar unit is a hexose. Allulose 6-phosphateAllulose 6-phosphoric acidD-Allulose 6-phosphateD-Allulose 6-phosphoric acidD-Allulose-6-PD-Allulose-6-phosphoric acidC6H11O9P258.12258.015166092(3R,4R,5R)-1,3,4,5-tetrahydroxy-6-(phosphonatooxy)hexan-2-oneD-allulose 6-phosphate[H][C@@](O)(COP([O-])([O-])=O)[C@@]([H])(O)[C@@]([H])(O)C(=O)COInChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h4-7,9-11H,1-2H2,(H2,12,13,14)/p-2/t4-,5+,6-/m1/s1GSXOAOHZAIYLCY-NGJCXOISSA-LCytosollogp-1.92logs-0.72solubility5.63e+01 g/llogp-3.4pka_strongest_acidic1.49pka_strongest_basic-3.3iupac(3R,4R,5R)-1,3,4,5-tetrahydroxy-6-(phosphonatooxy)hexan-2-oneaverage_mass258.12mono_mass258.015166092smiles[H][C@@](O)(COP([O-])([O-])=O)[C@@]([H])(O)[C@@]([H])(O)C(=O)COformulaC6H11O9PinchiInChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h4-7,9-11H,1-2H2,(H2,12,13,14)/p-2/t4-,5+,6-/m1/s1inchikeyGSXOAOHZAIYLCY-NGJCXOISSA-Lpolar_surface_area170.41refractivity46.19polarizability20.4rotatable_bond_count7acceptor_count8donor_count4physiological_charge-2formal_charge-2D-allulose degradationE. coli can utilize D-allose as the sole source of carbon for growth. D-allose is transported into the cell in unphosphorylated form via the D-allose ABC transporter. AlsK, the D-allose kinase which phosphorylates D-allose, is not essential for this pathway. Allose-6-phosphate isomerase and allulose-6-phosphate 3-epimerase catalyze the remaining reactions resulting in D-allulose 6 phosphate and Beta-D-fructofuranose 6-phosphate respectively. Once Beta D fructofuranose 6-phosphate is synthesized, it goes into the glycolysis and pyruvatedehydrogenase pathway.
PW000825MetabolicD-allose degradationPWY0-44Specdb::NmrOneD248968Specdb::NmrOneD248969Specdb::NmrOneD248970Specdb::NmrOneD248971Specdb::NmrOneD248972Specdb::NmrOneD248973Specdb::NmrOneD248974Specdb::NmrOneD248975Specdb::NmrOneD248976Specdb::NmrOneD248977Specdb::NmrOneD248978Specdb::NmrOneD248979Specdb::NmrOneD248980Specdb::NmrOneD248981Specdb::NmrOneD248982Specdb::NmrOneD248983Specdb::NmrOneD248984Specdb::NmrOneD248985Specdb::NmrOneD248986Specdb::NmrOneD2489872187289110618776D-ALLULOSE-6-PHOSPHATEKeseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590.21097882van der Werf, M. J., Overkamp, K. M., Muilwijk, B., Coulier, L., Hankemeier, T. (2007). "Microbial metabolomics: toward a platform with full metabolome coverage." Anal Biochem 370:17-25.17765195Winder, C. L., Dunn, W. B., Schuler, S., Broadhurst, D., Jarvis, R., Stephens, G. M., Goodacre, R. (2008). "Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites." Anal Chem 80:2939-2948.18331064D-allulose-6-phosphate 3-epimeraseP32719ALSE_ECOLIalsEhttp://ecmdb.ca/proteins/P32719.xmlRibose-5-phosphate isomerase BP37351RPIB_ECOLIrpiBhttp://ecmdb.ca/proteins/P37351.xmlD-Allulose-6-phosphate <> Fructose 6-phosphateRXN0-304D-Allose 6-phosphate <> D-Allulose-6-phosphateRXN0-303D-Allulose-6-phosphate > Fructose 6-phosphateRXN0-304D-Allose 6-phosphate > D-Allulose-6-phosphatealdehydo-D-allose 6-phosphate + aldehydo-D-allose 6-phosphate > D-allulose 6-phosphate + D-Allulose-6-phosphatePW_R002965D-allulose 6-phosphate + D-Allulose-6-phosphate > D-tagatofuranose 6-phosphatePW_R002966