2.02012-05-31 14:34:37 -06002015-06-03 17:19:36 -0600ECMDB20237M2MDB0010805-Methylaminomethyl-2-selenouridine5-methylaminomethyl-2-selenouridine is a member of the chemical class known as Pyrimidine Nucleosides and Analogues. These are compounds comprising a pyrimidine base attached to a sugar. 5-methylaminomethyl-2-selenouridine is invovled in Selenouridine biosynthesis (tRNA). 5-((Methylamino)methyl)-2-seleno-Uridine5-((Methylamino)methyl)-2-selenouridine5-MamsuMnm(5)se(2)UC11H17N3O5Se350.23351.0333424971-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-5-[(methylamino)methyl]-1,2-dihydropyrimidine-2-selone1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-5-[(methylamino)methyl]pyrimidine-2-selone89314-80-7[H][C@@]1(CO)O[C@]([H])(N2C=C(CNC)C(O)=NC2=[Se])[C@@]([H])(O)[C@@]1([H])OInChI=1S/C11H17N3O5Se/c1-12-2-5-3-14(11(20)13-9(5)18)10-8(17)7(16)6(4-15)19-10/h3,6-8,10,12,15-17H,2,4H2,1H3,(H,13,18,20)/t6-,7-,8-,10-/m0/s1LKYNRXHIWDCZMH-GHCJXIJMSA-NCytoplasmPeriplasmlogp-1.81logs-0.38solubility1.46e+02 g/llogp-2.8pka_strongest_acidic7.37pka_strongest_basic9.2iupac1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-5-[(methylamino)methyl]-1,2-dihydropyrimidine-2-seloneaverage_mass350.23mono_mass351.033342497smiles[H][C@@]1(CO)O[C@]([H])(N2C=C(CNC)C(O)=NC2=[Se])[C@@]([H])(O)[C@@]1([H])OformulaC11H17N3O5SeinchiInChI=1S/C11H17N3O5Se/c1-12-2-5-3-14(11(20)13-9(5)18)10-8(17)7(16)6(4-15)19-10/h3,6-8,10,12,15-17H,2,4H2,1H3,(H,13,18,20)/t6-,7-,8-,10-/m0/s1inchikeyLKYNRXHIWDCZMH-GHCJXIJMSA-Npolar_surface_area117.78refractivity77.72polarizability28.74rotatable_bond_count4acceptor_count7donor_count5physiological_charge1formal_charge0Specdb::CMs1087077Specdb::EiMs3552Specdb::NmrOneD290975Specdb::NmrOneD290976Specdb::NmrOneD290977Specdb::NmrOneD290978Specdb::NmrOneD290979Specdb::NmrOneD290980Specdb::NmrOneD290981Specdb::NmrOneD290982Specdb::NmrOneD290983Specdb::NmrOneD290984Specdb::NmrOneD290985Specdb::NmrOneD290986Specdb::NmrOneD290987Specdb::NmrOneD290988Specdb::NmrOneD290989Specdb::NmrOneD290990Specdb::NmrOneD290991Specdb::NmrOneD290992Specdb::NmrOneD290993Specdb::NmrOneD290994Specdb::MsMs24104Specdb::MsMs24105Specdb::MsMs24106Specdb::MsMs30902Specdb::MsMs30903Specdb::MsMs30904633632648916175-METHYLAMINOMETHYL-2-SELENOURIDINEKeseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590.21097882Winder, C. L., Dunn, W. B., Schuler, S., Broadhurst, D., Jarvis, R., Stephens, G. M., Goodacre, R. (2008). "Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites." Anal Chem 80:2939-2948.18331064tRNA 2-selenouridine synthaseP33667SELU_ECOLIselUhttp://ecmdb.ca/proteins/P33667.xml5-Methylaminomethyl-2-thiouridine + Phosphoroselenoic acid > 5-Methylaminomethyl-2-selenouridine + Inorganic phosphate