Record Information
Version2.0
Creation Date2012-05-31 14:18:48 -0600
Update Date2015-12-09 17:00:20 -0700
Secondary Accession Numbers
  • ECMDB10570
Identification
Name:PG(16:0/16:0)
DescriptionPG(16:0/16:0) is a phosphatidylglycerol. Phosphatidylglycerols consist of a glycerol 3-phosphate backbone esterified to either saturated or unsaturated fatty acids on carbons 1 and 2. As is the case with diacylglycerols, phosphatidylglycerols can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PG(16:0/16:0), in particular, consists of two hexadecanoyl chains at positions C-1 and C-2. In E. coli glycerophospholipid metabolism, phosphatidylglycerol is formed from phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by a sequence of enzymatic reactions that proceeds via two intermediates, cytidine diphosphate diacylglycerol (CDP-diacylglycerol) and phosphatidylglycerophosphate (PGP, a phosphorylated phosphatidylglycerol). Phosphatidylglycerols, along with CDP-diacylglycerol, also serve as precursor molecules for the synthesis of cardiolipin, a phospholipid found in membranes.
Structure
Thumb
Synonyms:
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-glycerol)
  • 1,2-dihexadecanoyl-rac-glycero-3-phospho-(1'-rac-glycerol)
  • 1,2-dihexadecanoyl-rac-glycero-3-phosphoglycerol
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoglycerol
  • 1-phosphatidylglycerol
  • 3(3-phosphatidyl-)glycerol
  • 3-(3-sn-phosphatidyl)glycerol
  • 3-(3-sn-Phosphatidyl)glycerol
  • GPG(16:0/16:0)
  • GPG(32:0)
  • PG(16:0/16:0)
  • PG(32:0)
  • Phosphatidylglycerol
  • Phosphatidylglycerol(16:0/16:0)
  • Phosphatidylglycerol(32:0)
Chemical Formula:C38H75O10P
Weight:Average: 722.982
Monoisotopic: 722.509785613
InChI Key:BIABMEZBCHDPBV-LQFQNGICSA-N
InChI:InChI=1S/C38H75O10P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-37(41)45-33-36(34-47-49(43,44)46-32-35(40)31-39)48-38(42)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h35-36,39-40H,3-34H2,1-2H3,(H,43,44)/t35-,36-/m1/s1
CAS number:Not Available
IUPAC Name:[(2R)-2,3-bis(hexadecanoyloxy)propoxy][(2R)-2,3-dihydroxypropoxy]phosphinic acid
Traditional IUPAC Name:(2R)-2,3-bis(hexadecanoyloxy)propoxy((2R)-2,3-dihydroxypropoxy)phosphinic acid
SMILES:[H][C@@](O)(CO)COP(O)(=O)OC[C@@]([H])(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC
Chemical Taxonomy
Description belongs to the class of organic compounds known as phosphatidylglycerols. These are glycerophosphoglycerols in which two fatty acids are bonded to the 1-glycerol moiety through ester linkages.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphoglycerols
Direct ParentPhosphatidylglycerols
Alternative Parents
Substituents
  • 1,2-diacylglycerophosphoglycerol
  • Fatty acid ester
  • Dialkyl phosphate
  • Dicarboxylic acid or derivatives
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Fatty acyl
  • 1,2-diol
  • Carboxylic acid ester
  • Secondary alcohol
  • Carboxylic acid derivative
  • Organic oxide
  • Organooxygen compound
  • Alcohol
  • Organic oxygen compound
  • Primary alcohol
  • Carbonyl group
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External DescriptorsNot Available
Physical Properties
State:Solid
Charge:-1
Melting point:Not Available
Experimental Properties:
PropertyValueSource
Predicted Properties
PropertyValueSource
Water Solubility0.00014 g/LALOGPS
logP7.8ALOGPS
logP10.94ChemAxon
logS-6.7ALOGPS
pKa (Strongest Acidic)1.89ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area148.82 ŲChemAxon
Rotatable Bond Count40ChemAxon
Refractivity195.31 m³·mol⁻¹ChemAxon
Polarizability87.25 ųChemAxon
Number of Rings0ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Membrane
Reactions:
Water + PGP(16:0/16:0) > PG(16:0/16:0) + Phosphate
applipoprotein + PG(16:0/16:0) > 2-Acyl-sn-glycero-3-phosphoglycerol (N-C16:0) + lipoprotein
2 PG(16:0/16:0) <> cardiolipin (tetrahexadecanoyl, n-C16:0) + Glycerol
Adenosine triphosphate + Water + PG(16:0/16:0) > ADP + Hydrogen ion + Phosphate + PG(16:0/16:0)
Adenosine triphosphate + Water + PG(16:0/16:0) > ADP + Hydrogen ion + Phosphate + PG(16:0/16:0)
2-Acyl-sn-glycero-3-phosphoglycerol (N-C16:0) + Adenosine triphosphate + Palmitic acid > Adenosine monophosphate + PG(16:0/16:0) + Pyrophosphate
Water + PG(16:0/16:0) > 1-Acyl-sn-glycero-3-phosphoglycerol (N-C16:0) + Hydrogen ion + Palmitic acid
Water + PG(16:0/16:0) > 2-Acyl-sn-glycero-3-phosphoglycerol (N-C16:0) + Hydrogen ion + Palmitic acid
2-Acyl-sn-glycero-3-phosphoethanolamine (N-C16:0) + PG(16:0/16:0) > Acyl phosphatidylglycerol (N-C16:0) + Glycerylphosphorylethanolamine
2-Acyl-sn-glycero-3-phosphoglycerol (N-C16:0) + PG(16:0/16:0) > Acyl phosphatidylglycerol (N-C16:0) + Glycerophosphoglycerol
Phosphatidylglycerophosphate + Water <> Phosphatidylglycerol + Phosphate + PG(16:0/16:0)
PG(16:0/16:0) + Membrane-derived-oligosaccharide D-glucose <> 1,2-Diacyl-sn-glycerol + Membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose
PG(16:0/16:0) + PE(15:0/16:0) > Ethanolamine + CL(15:0cyclo/16:0/16:0/16:0)
PE(15:0/16:1(9Z)) + PG(16:0/16:0) > Ethanolamine + CL(15:0cyclo/16:0/16:0/16:1(9Z))
PG(16:0/16:0) + PE(15:0/17:0cycw7c) > Ethanolamine + CL(15:0cyclo/16:0/16:0/17:0cycw7c)
PE(15:0/18:1(9Z)) + PG(16:0/16:0) > CL(15:0cyclo/16:0/16:0/18:1(9Z)) + Ethanolamine
PG(16:0/16:0) + PE(15:0/19:iso) > CL(15:0cyclo/16:0/16:0/19:0cycv8c) + Ethanolamine
PE(15:0/16:1(9Z)) + PG(16:0/16:0) > Ethanolamine + CL(15:0cyclo/16:0/16:1(9Z)/16:0)
PG(16:0/16:0) + PE(15:0/17:0cycw7c) > Ethanolamine + CL(15:0cyclo/16:0/17:0cycw7c/16:0)
PG(16:0/16:0) + PE(18:1(9Z)/15:0) > Ethanolamine + CL(15:0cyclo/16:0/18:1(9Z)/16:0)
PG(16:0/16:0) + PE(15:0/19:iso) > Ethanolamine + CL(15:0cyclo/16:0/19:0cycv8c/16:0)
PG(16:0/16:0) + PE(15:0/16:1(9Z)) > Ethanolamine + CL(15:0cyclo/16:1(9Z)/16:0/16:0)
PG(16:0/16:0) + PE(15:0/17:0cycw7c) > Ethanolamine + CL(15:0cyclo/17:0cycw7c/16:0/16:0)
PG(16:0/16:0) + PE(15:0/18:1(9Z)) > Ethanolamine + CL(15:0cyclo/18:1(9Z)/16:0/16:0)
PE(15:0/19:iso) + PG(16:0/16:0) > Ethanolamine + CL(15:0cyclo/19:0cycv8c/16:0/16:0)
PE(15:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(16:0/15:0cyclo/16:0/16:0)
PG(16:0/16:0) + PE(15:0/16:1(9Z)) > CL(16:0/15:0cyclo/16:0/16:1(9Z)) + Ethanolamine
PG(16:0/16:0) + PE(15:0/17:0cycw7c) > Ethanolamine + CL(16:0/15:0cyclo/16:0/17:0cycw7c)
PG(16:0/16:0) + PE(15:0/18:1(9Z)) > Ethanolamine + CL(16:0/15:0cyclo/16:0/18:1(9Z))
PE(15:0/19:iso) + PG(16:0/16:0) > Ethanolamine + CL(16:0/15:0cyclo/16:0/19:0cycv8c)
PG(16:0/16:0) + PE(15:0/16:1(9Z)) > Ethanolamine + CL(16:0/15:0cyclo/16:1(9Z)/16:0)
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/19:0cycv8c/14:0/18:1(9Z))
PE(15:0/17:0cycw7c) + PG(16:0/16:0) > Ethanolamine + CL(16:0/15:0cyclo/17:0cycw7c/16:0)
PG(16:0/16:0) + PE(18:1(9Z)/15:0) > CL(16:0/15:0cyclo/18:1(9Z)/16:0) + Ethanolamine
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/19:0cycv8c/18:1(9Z)/14:0)
PE(15:0/19:iso) + PG(16:0/16:0) > Ethanolamine + CL(16:0/15:0cyclo/19:0cycv8c/16:0)
PE(18:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/19:0cycv8c/19:0cycv8c/14:0)
PG(16:0/16:0) + PE(14:0/14:0) > Ethanolamine + CL(16:0/16:0/14:0/14:0)
PG(16:0/16:0) + PE(14:0/16:1(9Z)) > Ethanolamine + CL(16:0/16:0/14:0/16:1(9Z))
PE(14:0/17:0cycw7c) + PG(16:0/16:0) > Ethanolamine + CL(16:0/16:0/14:0/17:0cycw7c)
PG(16:0/16:0) + PE(14:0/18:1(9Z)) > Ethanolamine + CL(16:0/16:0/14:0/18:1(9Z))
PG(16:0/16:0) + PE(14:0/19:iso) > Ethanolamine + CL(16:0/16:0/14:0/19:0cycv8c)
PG(16:0/16:0) + PE(15:0/17:0cycw7c) > CL(16:0/16:0/16:0/17:0cycw7c) + Ethanolamine
PG(16:0/16:0) + PE(16:0/18:1(9Z)) > Ethanolamine + CL(16:0/16:0/16:0/18:1(9Z))
PG(16:0/16:0) + PE(16:0/19:0cycw8c) > CL(16:0/16:0/16:0/19:0cycv8c) + Ethanolamine
PG(16:0/16:0) + PE(14:0/16:1(9Z)) > Ethanolamine + CL(16:0/16:0/16:1(9Z)/14:0)
PG(16:0/16:0) + PE(15:0/16:1(9Z)) > CL(16:0/16:0/16:1(9Z)/15:0cyclo) + Ethanolamine
PG(16:0/16:0) + PE(16:0/16:1(9Z)) > Ethanolamine + CL(16:0/16:0/16:1(9Z)/16:0)
PG(16:0/16:0) + PE(16:1(9Z)/16:1(9Z)) > Ethanolamine + CL(16:0/16:0/16:1(9Z)/16:1(9Z))
PG(16:0/16:0) + PE(14:0/18:1(9Z)) > Ethanolamine + CL(16:0/16:0/18:1(9Z)/14:0)
PG(16:0/16:0) + PE(16:1(9Z)/17:0) > Ethanolamine + CL(16:0/16:0/16:1(9Z)/17:0cycw7c)
PG(16:0/16:0) + PE(16:1(9Z)/18:1(9Z)) > CL(16:0/16:0/16:1(9Z)/18:1(9Z)) + Ethanolamine
PG(16:0/16:0) + PE(16:1(9Z)/19:iso) > CL(16:0/16:0/16:1(9Z)/19:0cycv8c) + Ethanolamine
PG(16:0/16:0) + PE(14:0/17:0cycw7c) > Ethanolamine + CL(16:0/16:0/17:0cycw7c/14:0)
PG(16:0/16:0) + PE(15:0/17:0cycw7c) > Ethanolamine + CL(16:0/16:0/17:0cycw7c/15:0cyclo)
PG(16:0/16:0) + PE(15:0/17:0cycw7c) > Ethanolamine + CL(16:0/16:0/17:0cycw7c/16:0)
PG(16:0/16:0) + PE(16:1(9Z)/17:0) > Ethanolamine + CL(16:0/16:0/17:0cycw7c/16:1(9Z))
PG(16:0/16:0) + PE(17:0cycw7c/17:0cycw7c) > Ethanolamine + CL(16:0/16:0/17:0cycw7c/17:0cycw7c)
PG(16:0/16:0) + PE(18:0/17:0cycw7c) > Ethanolamine + CL(16:0/16:0/17:0cycw7c/18:1(9Z))
PG(16:0/16:0) + PE(17:0/19:0) > Ethanolamine + CL(16:0/16:0/17:0cycw7c/19:0cycv8c)
PG(16:0/16:0) + PE(18:1(9Z)/15:0) > Ethanolamine + CL(16:0/16:0/18:1(9Z)/15:0cyclo)
PG(16:0/16:0) + PE(16:0/18:1(9Z)) > CL(16:0/16:0/18:1(9Z)/16:0) + Ethanolamine
PG(16:0/16:0) + PE(16:1(9Z)/18:1(9Z)) > CL(16:0/16:0/18:1(9Z)/16:1(9Z)) + Ethanolamine
PG(16:0/16:0) + PE(18:0/17:0cycw7c) > Ethanolamine + CL(16:0/16:0/18:1(9Z)/17:0cycw7c)
PE(18:1(9Z)/18:1(9Z)) + PG(16:0/16:0) > Ethanolamine + CL(16:0/16:0/18:1(9Z)/18:1(9Z))
PG(16:0/16:0) + PE(18:1(9Z)/19:iso) > Ethanolamine + CL(16:0/16:0/18:1(9Z)/19:0cycv8c)
PG(16:0/16:0) + PE(14:0/19:iso) > Ethanolamine + CL(16:0/16:0/19:0cycv8c/14:0)
PG(16:0/16:0) + PE(15:0/19:iso) > Ethanolamine + CL(16:0/16:0/19:0cycv8c/15:0cyclo)
PG(16:0/16:0) + PE(16:0/19:0cycw8c) > Ethanolamine + CL(16:0/16:0/19:0cycv8c/16:0)
PE(16:1(9Z)/19:iso) + PG(16:0/16:0) Ethanolamine + CL(16:0/16:0/19:0cycv8c/16:1(9Z))
PG(16:0/16:0) + PE(17:0/19:0) > Ethanolamine + CL(16:0/16:0/19:0cycv8c/17:0cycw7c)
PG(16:0/16:0) + PE(18:1(9Z)/19:iso) > CL(16:0/16:0/19:0cycv8c/18:1(9Z)) + Ethanolamine
PG(16:0/16:0) + PE(16:1(9Z)/14:0) > Ethanolamine + CL(16:0/16:1(9Z)/14:0/16:0)
PG(16:0/16:0) + PE(16:0/14:0) > Ethanolamine + CL(16:0/16:1(9Z)/16:0/14:0)
PE(16:0/14:1(9Z)) + PG(16:0/16:0) > Ethanolamine + CL(16:0/16:1(9Z)/16:0/14:0)
PG(16:0/16:0) + PE(16:1(9Z)/16:1(9Z)) > Ethanolamine + CL(16:0/16:1(9Z)/16:0/16:1(9Z))
PG(16:0/16:0) + PE(16:1(9Z)/17:0) > Ethanolamine + CL(16:0/16:1(9Z)/16:0/17:0cycw7c)
PG(16:0/16:0) + PE(16:1(9Z)/18:1(9Z)) > Ethanolamine + CL(16:0/16:1(9Z)/16:0/18:1(9Z))
PE(16:1(9Z)/19:iso) + PG(16:0/16:0) > Ethanolamine + CL(16:0/16:1(9Z)/16:0/19:0cycv8c)
PG(16:0/16:0) + PE(16:1(9Z)/16:1(9Z)) > Ethanolamine + CL(16:0/16:1(9Z)/16:1(9Z)/16:0)
PG(16:0/16:0) + PE(16:1(9Z)/17:0) > Ethanolamine + CL(16:0/16:1(9Z)/17:0cycw7c/16:0)
PG(16:0/16:0) + PE(18:0/16:0) > Ethanolamine + CL(19:0cycv8c/16:0/16:1(9Z)/19:0cycv8c)
PG(16:0/16:0) + PE(16:1(9Z)/18:1(9Z)) > Ethanolamine + CL(16:0/16:1(9Z)/18:1(9Z)/16:0)
PE(16:1(9Z)/19:iso) + PG(16:0/16:0) > Ethanolamine + CL(16:0/16:1(9Z)/19:0cycv8c/16:0)
PG(16:0/16:0) + PE(18:0/16:0) > Ethanolamine + CL(19:0cycv8c/16:0/19:0cycv8c/16:1(9Z))
PG(16:0/16:0) + PE(14:0/17:0cycw7c) > CL(16:0/17:0cycw7c/14:0/16:0) + Ethanolamine
PE(14:0/17:0cycw7c) + PG(16:0/16:0) > Ethanolamine + CL(16:0/17:0cycw7c/16:0/14:0)
PG(16:0/16:0) + PE(17:0cycw7c/17:0cycw7c) > CL(16:0/17:0cycw7c/16:0/17:0cycw7c) + Ethanolamine
PG(16:0/16:0) + PE(14:0/18:1(9Z)) > Ethanolamine + CL(16:0/18:1(9Z)/14:0/16:0)
PG(16:0/16:0) + PE(14:0/18:1(9Z)) > Ethanolamine + CL(16:0/18:1(9Z)/16:0/14:0)
PE(18:0/17:0cycw7c) + PG(16:0/16:0) > Ethanolamine + CL(16:0/18:1(9Z)/16:0/17:0cycw7c)
PG(16:0/16:0) + PE(18:1(9Z)/18:1(9Z)) > CL(16:0/18:1(9Z)/16:0/18:1(9Z)) + Ethanolamine
PG(16:0/16:0) + PE(18:1(9Z)/19:iso) > Ethanolamine + CL(16:0/18:1(9Z)/16:0/19:0cycv8c)
PG(16:0/16:0) + PE(18:0/17:0cycw7c) > Ethanolamine + CL(16:0/18:1(9Z)/17:0cycw7c/16:0)
PE(18:1(9Z)/18:1(9Z)) + PG(16:0/16:0) > Ethanolamine + CL(16:0/18:1(9Z)/18:1(9Z)/16:0)
PG(16:0/16:0) + PE(18:1(9Z)/19:iso) > Ethanolamine + CL(16:0/18:1(9Z)/19:0cycv8c/16:0)
PG(16:0/16:0) + PE(14:0/19:iso) > Ethanolamine + CL(16:0/19:0cycv8c/14:0/16:0)
PG(16:0/16:0) + PE(14:0/19:iso) > CL(16:0/19:0cycv8c/16:0/14:0) + Ethanolamine
PG(16:0/16:0) + PE(17:0/19:0) > Ethanolamine + CL(16:0/19:0cycv8c/16:0/17:0cycw7c)
PG(16:0/16:0) + PE(17:0/19:0) > Ethanolamine + CL(16:0/19:0cycv8c/17:0cycw7c/16:0)
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(19:0cycv8c/17:0cycw7c/19:0cycv8c/14:0)
PG(16:0/16:0) + PE(14:0/16:1(9Z)) > Ethanolamine + CL(16:1(9Z)/16:0/14:0/16:0)
PG(16:0/16:0) + PE(14:0/16:1(9Z)) > CL(16:1(9Z)/16:0/16:0/14:0) + Ethanolamine
PG(16:0/16:0) + PE(16:1(9Z)/17:0) > Ethanolamine + CL(16:1(9Z)/16:0/16:0/17:0cycw7c)
PG(16:0/16:0) + PE(16:1(9Z)/18:1(9Z)) > CL(16:1(9Z)/16:0/16:0/18:1(9Z)) + Ethanolamine
PE(16:1(9Z)/19:iso) + PG(16:0/16:0) > CL(16:1(9Z)/16:0/16:0/19:0cycv8c) + Ethanolamine
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(17:0cycw7c/19:0cycv8c/19:0cycv8c/14:0)
PE(16:1(9Z)/16:1(9Z)) + PG(16:0/16:0) > Ethanolamine + CL(16:1(9Z)/16:0/16:1(9Z)/16:0)
PG(16:0/16:0) + PE(16:1(9Z)/17:0) > Ethanolamine + CL(16:1(9Z)/16:0/17:0cycw7c/16:0)
PG(16:0/16:0) + PE(16:1(9Z)/18:1(9Z)) > Ethanolamine + CL(16:1(9Z)/16:0/18:1(9Z)/16:0)
PE(16:1(9Z)/19:iso) + PG(16:0/16:0) > Ethanolamine + CL(16:1(9Z)/16:0/19:0cycv8c/16:0)
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/15:0cyclo/18:1(9Z)/18:1(9Z))
PE(18:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/15:0cyclo/19:0cycv8c/18:1(9Z))
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/16:0/17:0cycw7c/18:1(9Z))
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/16:0/18:1(9Z)/17:0cycw7c)
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/16:0/19:0cycv8c/16:0)
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/16:1(9Z)/16:1(9Z)/19:0cycv8c)
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/16:1(9Z)/19:0cycv8c/16:1(9Z))
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/17:0cycw7c/17:0cycw7c/17:0cycw7c)
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/18:1(9Z)/14:0/19:0cycv8c)
PG(16:0/16:0) + PE(14:0/17:0cycw7c) > Ethanolamine + CL(17:0cycw7c/16:0/14:0/16:0)
PG(16:0/16:0) + PE(14:0/17:0cycw7c) > CL(17:0cycw7c/16:0/16:0/14:0) + Ethanolamine
PG(16:0/16:0) + PE(17:0cycw7c/17:0cycw7c) > Ethanolamine + CL(16:0/17:0cycw7c/17:0cycw7c/16:0)
PE(18:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(18:1(9Z)/18:1(9Z)/17:0cycw7c/17:0cycw7c)
PE(17:0cycw7c/17:0cycw7c) + PG(16:0/16:0) > Ethanolamine + CL(17:0cycw7c/16:0/17:0cycw7c/16:0)
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(17:0cycw7c/16:1(9Z)/19:0cycv8c/17:0cycw7c)
PE(18:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(16:1(9Z)/16:0/19:0cycv8c/19:0cycv8c)
PE(19:0cycw8c/17:0cycw7c) + PG(16:0/16:0) > Ethanolamine + CL(19:0cycv8c/16:0/16:0/17:0cycw7c)
PE(19:0cycv8c/14:0(3-OH)) + PG(16:0/16:0) > Ethanolamine + CL(19:0cycv8c/16:0/16:0/14:0)
PG(16:0/16:0) + PE(19:0cycw8c/17:0cycw7c) > Ethanolamine + CL(19:0cycv8c/16:0/17:0cycw7c/16:0)
PG(16:0/16:0) + PE(18:1(9Z)/19:iso) > CL(18:1(9Z)/16:0/19:0cycv8c/16:0) + Ethanolamine
PE(17:0/16:0) + PG(16:0/16:0) > Ethanolamine + CL(17:0cycw7c/18:1(9Z)/17:0cycw7c/17:0cycw7c)
PE(14:0(3-OH)/16:0) + PG(16:0/16:0) > Ethanolamine + CL(14:0(3-OH)/16:0/16:0/16:0)
PE(16:1(9Z)/19:0) + PG(16:0/16:0) > Ethanolamine + CL(16:1(9Z)/19:0/16:0/16:0)
PE(17:0/16:1(9Z)) + PG(16:0/16:0) > Ethanolamine + CL(17:0/16:1(9Z)/16:0/16:0)
2 PGP(16:0/16:0) + Water >2 PG(16:0/16:0) + Phosphate
2 PG(16:0/16:0) > Glycerol + CL(16:0/16:0/16:0/16:0)
Phosphatidylglycerophosphate + Water <> PG(16:0/16:0) + Phosphate
Phosphatidylglycerophosphate + Water <> PG(16:0/16:0) + Phosphate
More...

SMPDB Pathways:
phospholipid biosynthesis (CL(14:0(3-OH)/16:0/16:0/16:0))PW001938 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis (CL(16:0/16:0/16:0/16:0))PW002010 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis (CL(16:1(9Z)/19:0/16:0/16:0))PW001961 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis (CL(17:0/16:1(9Z)/16:0/16:0))PW001964 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis (CL(18:1(9Z)/16:0/19:0cycv8c/16:0))PW001598 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis (CL(18:1(9Z)/18:1(9Z)/17:0cycw7c/17:0cycw7c))PW001679 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis (CL(19:0cycv8c/16:0/16:0/14:0))PW001323 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis (CL(19:0cycv8c/16:0/16:0/17:0cycw7c))PW001324 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis (CL(19:0cycv8c/16:0/17:0cycw7c/16:0))PW001331 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/16:0/16:0/16:0)PW001100 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/16:0/16:0/16:1(9Z))PW001102 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/16:0/16:0/17:0cycw7c)PW001103 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/16:0/16:0/18:1(9Z))PW001104 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/16:0/16:0/19:0cycv8c)PW001105 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/16:0/16:1(9Z)/16:0)PW001106 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/16:0/17:0cycw7c/16:0)PW001109 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/16:0/18:1(9Z)/16:0)PW001112 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/16:0/19:0cycv8c/16:0)PW001115 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/16:1(9Z)/16:0/16:0)PW001124 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/17:0cycw7c/16:0/16:0)PW001145 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/18:1(9Z)/16:0/16:0)PW001165 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(15:0cyclo/19:0cycv8c/16:0/16:0)PW001189 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/15:0cyclo/16:0/16:0)PW001226 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/15:0cyclo/16:0/16:1(9Z))PW001227 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/15:0cyclo/16:0/17:0cycw7c)PW001228 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/15:0cyclo/16:0/18:1(9Z))PW001229 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/15:0cyclo/16:0/19:0cycv8c)PW001230 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/15:0cyclo/16:1(9Z)/16:0)PW001232 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/15:0cyclo/17:0cycw7c/16:0)PW001237 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/15:0cyclo/18:1(9Z)/16:0)PW001242 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/15:0cyclo/19:0cycv8c/16:0)PW001246 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/14:0/14:0)PW001250 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/14:0/16:1(9Z))PW001252 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/14:0/17:0cycw7c)PW001254 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/14:0/18:1(9Z))PW001255 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/14:0/19:0cycv8c)PW001256 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/16:0/17:0cycw7c)PW001257 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/16:0/18:1(9Z))PW001258 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/16:0/19:0cycv8c)PW001259 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/16:1(9Z)/14:0)PW001260 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/16:1(9Z)/15:0cyclo)PW001261 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/16:1(9Z)/16:0)PW001264 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/16:1(9Z)/16:1(9Z))PW001265 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/16:1(9Z)/17:0cycw7c)PW001267 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/16:1(9Z)/18:1(9Z))PW001268 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/16:1(9Z)/19:0cycv8c)PW001269 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/17:0cycw7c/14:0)PW001270 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/17:0cycw7c/15:0cyclo)PW001271 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/17:0cycw7c/16:0)PW001272 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/17:0cycw7c/16:1(9Z))PW001273 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/17:0cycw7c/17:0cycw7c)PW001274 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/17:0cycw7c/18:1(9Z))PW001277 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/17:0cycw7c/19:0cycv8c)PW001278 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/18:1(9Z)/14:0)PW001266 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/18:1(9Z)/15:0cyclo)PW001279 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/18:1(9Z)/16:0)PW001280 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/18:1(9Z)/16:1(9Z))PW001281 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/18:1(9Z)/17:0cycw7c)PW001282 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/18:1(9Z)/18:1(9Z))PW001283 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/18:1(9Z)/19:0cycv8c)PW001284 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/19:0cycv8c/14:0)PW001285 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/19:0cycv8c/15:0cyclo)PW001286 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/19:0cycv8c/16:0)PW001287 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/19:0cycv8c/16:1(9Z))PW001288 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/19:0cycv8c/17:0cycw7c)PW001289 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:0/19:0cycv8c/18:1(9Z))PW001290 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:1(9Z)/14:0/16:0)PW001294 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:1(9Z)/16:0/14:0)PW001296 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:1(9Z)/16:0/16:1(9Z))PW001297 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:1(9Z)/16:0/17:0cycw7c)PW001303 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:1(9Z)/16:0/18:1(9Z))PW001305 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:1(9Z)/16:0/19:0cycv8c)PW001306 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:1(9Z)/16:1(9Z)/16:0)PW001308 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:1(9Z)/17:0cycw7c/16:0)PW001315 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:1(9Z)/18:1(9Z)/16:0)PW001328 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/16:1(9Z)/19:0cycv8c/16:0)PW001335 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/17:0cycw7c/14:0/16:0)PW001338 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/17:0cycw7c/16:0/14:0)PW001342 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/17:0cycw7c/16:0/17:0cycw7c)PW001343 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/18:1(9Z)/14:0/16:0)PW001356 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/18:1(9Z)/16:0/14:0)PW001358 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/18:1(9Z)/16:0/17:0cycw7c)PW001359 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/18:1(9Z)/16:0/18:1(9Z))PW001360 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/18:1(9Z)/16:0/19:0cycv8c)PW001361 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/18:1(9Z)/17:0cycw7c/16:0)PW001364 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/18:1(9Z)/18:1(9Z)/16:0)PW001368 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/18:1(9Z)/19:0cycv8c/16:0)PW001379 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/19:0cycv8c/14:0/16:0)PW001389 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/19:0cycv8c/16:0/14:0)PW001391 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/19:0cycv8c/16:0/17:0cycw7c)PW001392 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:0/19:0cycv8c/17:0cycw7c/16:0)PW001399 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:1(9Z)/16:0/14:0/16:0)PW001471 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:1(9Z)/16:0/16:0/14:0)PW001477 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:1(9Z)/16:0/16:0/17:0cycw7c)PW001478 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:1(9Z)/16:0/16:0/18:1(9Z))PW001479 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:1(9Z)/16:0/16:0/19:0cycv8c)PW001480 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:1(9Z)/16:0/16:1(9Z)/16:0)PW001486 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:1(9Z)/16:0/17:0cycw7c/16:0)PW001491 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:1(9Z)/16:0/18:1(9Z)/16:0)PW001501 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:1(9Z)/16:0/19:0cycv8c/16:0)PW001505 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(16:1(9Z)/16:0/19:0cycv8c/19:0cycv8c)PW001509 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(17:0cycw7c/16:0/14:0/16:0)PW001663 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(17:0cycw7c/16:0/16:0/14:0)PW001675 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(17:0cycw7c/16:0/16:0/17:0cycw7c)PW001676 ThumbThumb?image type=greyscaleThumb?image type=simple
phospholipid biosynthesis CL(17:0cycw7c/16:0/17:0cycw7c/16:0)PW001681 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways:
EcoCyc Pathways:
Concentrations
Not Available
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-06g0-5270921800-2b3ee5fead06797c6fa7View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0ara-7292521200-5a218add07d7a40c48b3View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0r2a-9262173000-ca5699ec79ac99e2bda4View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0abi-1190301300-a0850e4c17ff24556602View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0a6r-5291101000-06b6d8edc5bfefcc5f51View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9010000000-9df0309ddfba460b5dbdView in MoNA
References
References:
  • Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. Pubmed: 22080510
  • Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. Pubmed: 21097882
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
  • Yurtsever D. (2007). Fatty acid methyl ester profiling of Enterococcus and Esherichia coli for microbial source tracking. M.sc. Thesis. Villanova University: U.S.A
Synthesis Reference:Not Available
Material Safety Data Sheet (MSDS)Not Available
External Links:
ResourceLink
CHEBI IDNot Available
HMDB IDHMDB10570
Pubchem Compound ID13305396
Kegg IDC00344
ChemSpider ID393791
Wikipedia IDNot Available
BioCyc IDL-1-PHOSPHATIDYL-GLYCEROL
EcoCyc IDL-1-PHOSPHATIDYL-GLYCEROL
Ligand ExpoLHG

Enzymes

General function:
Lipid transport and metabolism
Specific function:
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate
Gene Name:
pldB
Uniprot ID:
P07000
Molecular weight:
38978
Reactions
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
General function:
Involved in phospholipase activity
Specific function:
Has broad substrate specificity including hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Strong expression leads to outer membrane breakdown and cell death; is dormant in normal growing cells. Required for efficient secretion of bacteriocins
Gene Name:
pldA
Uniprot ID:
P0A921
Molecular weight:
33163
Reactions
Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate.
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
General function:
Involved in catalytic activity
Specific function:
Hydrolyzes phosphatidylglycerophosphate, phosphatidic acid, and lysophosphatidic acid; the pattern of activities varies according to subcellular location
Gene Name:
pgpB
Uniprot ID:
P0A924
Molecular weight:
29021
Reactions
Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate.
General function:
Involved in phosphatidylglycerophosphatase activity
Specific function:
One of the three phospholipid phosphatases, specifically hydrolyzes phosphatidylglycerophosphate
Gene Name:
pgpA
Uniprot ID:
P18200
Molecular weight:
19418
Reactions
Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate.
General function:
Involved in transferase activity, transferring acyl groups
Specific function:
Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1
Gene Name:
aas
Uniprot ID:
P31119
Molecular weight:
80699
Reactions
Acyl-[acyl-carrier-protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier-protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine.
ATP + an acid + [acyl-carrier-protein] = AMP + diphosphate + acyl-[acyl-carrier-protein].
General function:
Involved in nucleotide binding
Specific function:
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
Gene Name:
msbA
Uniprot ID:
P60752
Molecular weight:
64460
General function:
Involved in lipid binding
Specific function:
Interacts with the peptidoglycan both covalently and noncovalently. This interaction contributes to the maintenance of the structural and functional integrity of the cell envelope
Gene Name:
lpp
Uniprot ID:
P69776
Molecular weight:
8323
General function:
Not Available
Specific function:
Not known; overproduction leads to camphor resistance and chromosome condensation
Gene Name:
crcA
Uniprot ID:
P37001
Molecular weight:
21770
General function:
Involved in phosphotransferase activity, for other substituted phosphate groups
Specific function:
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Affects resistance to the gyrase inhibitor novobiocin
Gene Name:
cls
Uniprot ID:
P0A6H8
Molecular weight:
54822
Reactions
2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.
General function:
Involved in N-acyltransferase activity
Specific function:
Transfers the fatty acyl group on membrane lipoproteins
Gene Name:
lnt
Uniprot ID:
P23930
Molecular weight:
57065
General function:
Involved in catalytic activity
Specific function:
Catalyzes, in vitro, the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Can also catalyze phosphatidyl group transfer to water to form phosphatidate. Catalyzes little, if any, cardiolipin synthesis in vivo, even when the expression level is very high
Gene Name:
ybhO
Uniprot ID:
P0AA84
Molecular weight:
47633
Reactions
2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.
General function:
cardiolipin biosynthetic process
Specific function:
Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE).
Gene Name:
clsC
Uniprot ID:
P75919
Molecular weight:
53665
Reactions
Phosphatidylglycerol + phosphatidylethanolamine = diphosphatidylglycerol + ethanolamine
General function:
phospholipid catabolic process
Specific function:
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).
Gene Name:
pgpC
Uniprot ID:
P0AD42
Molecular weight:
24439
Reactions
Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate

Transporters

General function:
Involved in phospholipid transporter activity
Specific function:
Part of the ABC transporter complex mlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
Gene Name:
mlaB
Uniprot ID:
P64602
Molecular weight:
10680
General function:
Involved in nucleotide binding
Specific function:
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
Gene Name:
msbA
Uniprot ID:
P60752
Molecular weight:
64460
General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
Part of the ABC transporter complex mlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
Gene Name:
mlaD
Uniprot ID:
P64604
Molecular weight:
19576
General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
Part of the ABC transporter complex mlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane
Gene Name:
mlaE
Uniprot ID:
P64606
Molecular weight:
27863