Zinc (ECMDB01303) (M2MDB000330)
| Record Information | ||||||||||||||||||||||||||||||||||||||||||||||
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| Version | 2.0 | |||||||||||||||||||||||||||||||||||||||||||||
| Creation Date | 2012-05-31 13:49:28 -0600 | |||||||||||||||||||||||||||||||||||||||||||||
| Update Date | 2015-09-18 09:21:20 -0600 | |||||||||||||||||||||||||||||||||||||||||||||
| Secondary Accession Numbers |
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| Identification | ||||||||||||||||||||||||||||||||||||||||||||||
| Name: | Zinc | |||||||||||||||||||||||||||||||||||||||||||||
| Description: | Zinc is an essential element, necessary for sustaining all life. It is an essential trace element, necessary for plants, animals, and microorganisms. Zinc is found in nearly 100 specific enzymes (other sources say 300), serves as structural ions in transcription factors and is stored and transferred in metallothioneins. It is "typically the second most abundant transition metal in organisms" after iron and it is the only metal which appears in all enzyme classes. (Wikipedia) | |||||||||||||||||||||||||||||||||||||||||||||
| Structure |  | |||||||||||||||||||||||||||||||||||||||||||||
| Synonyms: |
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| Chemical Formula: | Zn | |||||||||||||||||||||||||||||||||||||||||||||
| Weight: | Average: 65.409 Monoisotopic: 63.929146578 | |||||||||||||||||||||||||||||||||||||||||||||
| InChI Key: | HCHKCACWOHOZIP-UHFFFAOYSA-N | |||||||||||||||||||||||||||||||||||||||||||||
| InChI: | InChI=1S/Zn | |||||||||||||||||||||||||||||||||||||||||||||
| CAS number: | 7440-66-6 | |||||||||||||||||||||||||||||||||||||||||||||
| IUPAC Name: | zinc(2+) ion | |||||||||||||||||||||||||||||||||||||||||||||
| Traditional IUPAC Name: | zinc(2+) ion | |||||||||||||||||||||||||||||||||||||||||||||
| SMILES: | [Zn] | |||||||||||||||||||||||||||||||||||||||||||||
| Chemical Taxonomy | ||||||||||||||||||||||||||||||||||||||||||||||
| Description | belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom. | |||||||||||||||||||||||||||||||||||||||||||||
| Kingdom | Inorganic compounds | |||||||||||||||||||||||||||||||||||||||||||||
| Super Class | Homogeneous metal compounds | |||||||||||||||||||||||||||||||||||||||||||||
| Class | Homogeneous transition metal compounds | |||||||||||||||||||||||||||||||||||||||||||||
| Sub Class | Not Available | |||||||||||||||||||||||||||||||||||||||||||||
| Direct Parent | Homogeneous transition metal compounds | |||||||||||||||||||||||||||||||||||||||||||||
| Alternative Parents | Not Available | |||||||||||||||||||||||||||||||||||||||||||||
| Substituents |
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| Molecular Framework | Not Available | |||||||||||||||||||||||||||||||||||||||||||||
| External Descriptors |
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| Physical Properties | ||||||||||||||||||||||||||||||||||||||||||||||
| State: | Solid | |||||||||||||||||||||||||||||||||||||||||||||
| Charge: | 2 | |||||||||||||||||||||||||||||||||||||||||||||
| Melting point: | 419.5 °C | |||||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties: |
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| Predicted Properties |
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| Biological Properties | ||||||||||||||||||||||||||||||||||||||||||||||
| Cellular Locations: | Cytoplasm | |||||||||||||||||||||||||||||||||||||||||||||
| Reactions: | Adenosine triphosphate + Water + Zinc > ADP + Hydrogen ion + Phosphate + Zinc Adenosine triphosphate + Water + Zinc > ADP + Hydrogen ion + Phosphate + Zinc Adenosine triphosphate + Water + Zinc > ADP + Hydrogen ion + Phosphate + Zinc Adenosine triphosphate + Water + Zinc > ADP + Hydrogen ion + Phosphate + Zinc Zinc + Water + Adenosine triphosphate > Zinc + ADP + Phosphate + Hydrogen ion Zinc + Water + Adenosine triphosphate > Zinc + ADP + Phosphate + Hydrogen ion Zinc + Water + Adenosine triphosphate > Zinc + ADP + Phosphate + Hydrogen ion Zinc + Water + Adenosine triphosphate > Zinc + ADP + Phosphate + Hydrogen ion Zinc + Adenosine triphosphate + Water > ADP + Phosphate + Hydrogen ion | |||||||||||||||||||||||||||||||||||||||||||||
| SMPDB Pathways: |
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| KEGG Pathways: | ||||||||||||||||||||||||||||||||||||||||||||||
| EcoCyc Pathways: | Not Available | |||||||||||||||||||||||||||||||||||||||||||||
| Concentrations | ||||||||||||||||||||||||||||||||||||||||||||||
Find out more about how we convert literature concentrations. | ||||||||||||||||||||||||||||||||||||||||||||||
| Spectra | ||||||||||||||||||||||||||||||||||||||||||||||
| Spectra: |
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| References | ||||||||||||||||||||||||||||||||||||||||||||||
| References: |
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| Synthesis Reference: | Not Available | |||||||||||||||||||||||||||||||||||||||||||||
| Material Safety Data Sheet (MSDS) | Download (PDF) | |||||||||||||||||||||||||||||||||||||||||||||
| Links | ||||||||||||||||||||||||||||||||||||||||||||||
| External Links: |
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Enzymes
- General function:
- Involved in nucleotide binding
- Specific function:
- Involved in export of lead, cadmium, zinc and mercury
- Gene Name:
- zntA
- Uniprot ID:
- P37617
- Molecular weight:
- 76839
Reactions
| ATP + H(2)O + Cd(2+)(In) = ADP + phosphate + Cd(2+)(Out). |
| ATP + H(2)O + Zn(2+)(In) = ADP + phosphate + Zn(2+)(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system
- Gene Name:
- znuC
- Uniprot ID:
- P0A9X1
- Molecular weight:
- 27867
- General function:
- Involved in ATP binding
- Specific function:
- Involved in the high-affinity zinc uptake transport system
- Gene Name:
- znuB
- Uniprot ID:
- P39832
- Molecular weight:
- 27728
- General function:
- Involved in metal ion binding
- Specific function:
- Involved in the high-affinity zinc uptake transport system
- Gene Name:
- znuA
- Uniprot ID:
- P39172
- Molecular weight:
- 33777
Transporters
- General function:
- Involved in metal ion transmembrane transporter activity
- Specific function:
- Mediates zinc uptake. May also transport other divalent cations
- Gene Name:
- zupT
- Uniprot ID:
- B1XG45
- Molecular weight:
- 26484
- General function:
- Involved in metal ion transmembrane transporter activity
- Specific function:
- Mediates zinc uptake. May also transport other divalent cations
- Gene Name:
- zupT
- Uniprot ID:
- C4ZQV8
- Molecular weight:
- 26484
- General function:
- Involved in metal ion transmembrane transporter activity
- Specific function:
- Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions
- Gene Name:
- zupT
- Uniprot ID:
- P0A8H3
- Molecular weight:
- 26484
- General function:
- Involved in cation transmembrane transporter activity
- Specific function:
- Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas zntA is required for growth at more toxic concentrations
- Gene Name:
- zitB
- Uniprot ID:
- P75757
- Molecular weight:
- 34678
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system
- Gene Name:
- znuC
- Uniprot ID:
- P0A9X1
- Molecular weight:
- 27867
- General function:
- Involved in transporter activity
- Specific function:
- Non-specific porin
- Gene Name:
- ompN
- Uniprot ID:
- P77747
- Molecular weight:
- 41220
- General function:
- Involved in cation transmembrane transporter activity
- Specific function:
- Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton- dependent manner
- Gene Name:
- fieF
- Uniprot ID:
- P69380
- Molecular weight:
- 32927
- General function:
- Involved in transporter activity
- Specific function:
- Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
- Gene Name:
- phoE
- Uniprot ID:
- P02932
- Molecular weight:
- 38922
- General function:
- Involved in ATP binding
- Specific function:
- Involved in the high-affinity zinc uptake transport system
- Gene Name:
- znuB
- Uniprot ID:
- P39832
- Molecular weight:
- 27728
- General function:
- Involved in transporter activity
- Specific function:
- OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
- Gene Name:
- ompF
- Uniprot ID:
- P02931
- Molecular weight:
- 39333
- General function:
- Involved in metal ion binding
- Specific function:
- Involved in the high-affinity zinc uptake transport system
- Gene Name:
- znuA
- Uniprot ID:
- P39172
- Molecular weight:
- 33777
- General function:
- Involved in transporter activity
- Specific function:
- Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
- Gene Name:
- ompC
- Uniprot ID:
- P06996
- Molecular weight:
- 40368