1-Deoxy-D-xylulose 5-phosphate (ECMDB01213) (M2MDB000301)

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + D-xylulose = ADP + D-xylulose 5- phosphate

Gene Name:

xylB

Uniprot ID:

P09099

Molecular weight:

52618

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of thiI in a transpersulfidation reaction. Transfers sulfur on 'Cys-19' of tusA in a transpersulfidation reaction. Functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate

Gene Name:

iscS

Uniprot ID:

P0A6B7

Molecular weight:

45089

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate

Gene Name:

pdxJ

Uniprot ID:

P0A794

Molecular weight:

26384

Reactions

General function:

Involved in 4-hydroxythreonine-4-phosphate dehydrogenase activity

Specific function:

Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

Gene Name:

pdxA

Uniprot ID:

P19624

Molecular weight:

35114

Reactions

General function:

Involved in 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity

Specific function:

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

Gene Name:

dxr

Uniprot ID:

P45568

Molecular weight:

43388

Reactions

General function:

Involved in 1-deoxy-D-xylulose-5-phosphate synthase activity

Specific function:

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

Gene Name:

dxs

Uniprot ID:

P77488

Molecular weight:

67616

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein ThiS

Gene Name:

thiF

Uniprot ID:

P30138

Molecular weight:

26970

Reactions

General function:

Involved in RNA binding

Specific function:

Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by iscS

Gene Name:

thiI

Uniprot ID:

P77718

Molecular weight:

54973

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S

Gene Name:

thiG

Uniprot ID:

P30139

Molecular weight:

26896

Reactions

General function:

Coenzyme transport and metabolism

Specific function:

Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate

Gene Name:

thiS

Uniprot ID:

O32583

Molecular weight:

7311

General function:

Involved in catalytic activity

Specific function:

Catalyzes the radical-mediated cleavage of tyrosine to dehydroglycine and p-cresol

Gene Name:

thiH

Uniprot ID:

P30140

Molecular weight:

43320

Reactions