2.02012-05-31 13:02:20 -06002015-09-13 12:56:09 -0600ECMDB00939M2MDB000205S-AdenosylhomocysteineS-Adenosylhomocysteine (AdoHcy) is the immediate precursor of homocysteine. The reaction is catalyzed by S-adenosylhomocysteine hydrolase and is reversible with the equilibrium favoring formation of AdoHcy. In vivo, the reaction is driven in the direction of homocysteine formation by the action of the enzyme adenosine deaminase, which converts the second product of the S-adenosylhomocysteine hydrolase reaction, adenosine, to inosine. Except for methyl transfer from betaine and from methylcobalamin in the methionine synthase reaction, AdoHcy is the product of all methylation reactions that involve S-adenosylmethionine (AdoMet) as the methyl donor. (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine2-<i>S</i>-adenosyl-L-homocysteine2-S-Adenosyl-L-homocysteine5'-Deoxy-S-adenosyl-L-homocysteine5'-S-(3-Amino-3-carboxypropyl)-5'-thio-L-Adenosine<i>S</i>-adenosyl-homocysteine<i>S</i>-adenosylhomocysteineAdenosyl-homo-CYSAdenosyl-L-homocysteineAdenosylhomo-CYSAdenosylhomocysteineAdohcyFormycinylhomocysteineL-5'-S-(3-Amino-3-carboxypropyl)-5'-thior-AdenosineL-S-Adenosyl-HomocysteineL-S-AdenosylhomocysteineS-(5'-Adenosyl)-L-homocysteineS-(5'-Deoxyadenosin-5'-yl)-L-homocysteineS-(5'-Deoxyadenosine-5')-L-homocysteineS-Adenosyl-homocysteineS-Adenosyl-L-homocysteineS-adenosylhomocysteineSAHSAHCC14H20N6O5S384.411384.12158847(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acidS-adenosyl-L-homocysteine979-92-0N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=OInChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1ZJUKTBDSGOFHSH-WFMPWKQPSA-NSolidCytosollogp-2.37logs-1.97solubility4.08e+00 g/lmelting_point209-211 oClogp-4pka_strongest_acidic1.81pka_strongest_basic9.5iupac(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acidaverage_mass384.411mono_mass384.12158847smilesN[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=OformulaC14H20N6O5SinchiInChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1inchikeyZJUKTBDSGOFHSH-WFMPWKQPSA-Npolar_surface_area182.63refractivity92.72polarizability38.41rotatable_bond_count7acceptor_count10donor_count5physiological_charge0formal_charge0Cysteine and methionine metabolismec00270Porphyrin and chlorophyll metabolismec00860Biotin metabolismBiotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase.In E. coli and many organisms, pimelate thioester is derived from malonyl-ACP. The pathway starts with a malonyl-[acp] interacting with S-adenosylmethionine through a biotin synthesis protein BioC resulting in a S-adenosylhomocysteine and a malonyl-[acp] methyl ester. The latter compound is then involved in the synthesis of a 3-ketoglutaryl-[acp] methyl ester through a 3-oxoacyl-[acyl-carrier-protein] synthase. The compound 3-ketoglutaryl-[acp] methyl ester is reduced by a NADPH mediated 3-oxoacyl-[acyl-carrier-protein] reductase resulting in a 3R-hydroxyglutaryl-[acp] methyl ester. This compound is then dehydrated through ad (3R)-hydroxymyristoyl-[acp] dehydratase producing a enoylglutaryl-[acp] methyl ester. This compound is then reduced through a NADPH mediated enoyl-acp-reductase [NADH] resulting in a glutaryl-[acp] methyl ester. This compound interacts with a malonyl-[acp] through a 3-oxoacyl-[acp] synthase 2 resulting in a 3-ketopimeloyl [acp] methyl ester. This compound is then reduced through a NADPH 3-oxoacyl [acp] reductase producing a 3-hydroxypimeloyl-[acp] methyl ester and then dehydrated by (3R)-hydroxymyristoyl-[acp] dehydratase to produce a enoylpimeloyl-[acp] methyl ester. This compound is then reduced by a NADPH dependent enoyl-[acp]reductase resulting in a pimeloyl-[acp] methyl ester. This compound then reacts with water through a carboxylesterase resulting in a pimeloyl-[acp] and a methanol. The pimeloyl-acp reacts with L-alanine through a 8-amino-7-oxononanoate synthase resulting in 8-amino-7-oxononanoate which in turn reacts with S-adenosylmethionine through a 7,8 diaminonanoate transaminase resulting in a S-adenosyl-4-methylthio-2-oxobutanoate and 7,8 diaminononanoate. The latter compound is then dephosphorylated through a dethiobiotin synthetase resulting in a dethiobiotin. This compound interacts with a sulfurated[sulfur carrier), a hydrogen ion and a S-adenosylmethionine through a biotin synthase to produce Biotin and releasing l-methionine and a 5-deoxyadenosine.
Biotin is then metabolized by a bifunctional protein resulting in pyrophosphate and Biotinyl-5-AMP which in turn reacts with the same protein (bifunctional protein birA resulting ina biotin caroxyl carrying protein.This product then enters the fatty acid biosynthesis.
PW000762ec00780MetabolicUbiquinone and other terpenoid-quinone biosynthesisec00130Two-component systemec02020Mismatch repaireco03430Metabolic pathwayseco01100Menaquinol biosythesisMenaquinol biosynthesis starts with chorismate being metabolized into isochorismate through a isochorismate synthase. Isochorismate then interacts with 2-oxoglutare and a hydrogen ion through a 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase resulting in the release of a carbon dioxide and a 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate. The latter compound then interacts with (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase resulting in the release of a pyruvate and a (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate. This compound is the dehydrated through a o-succinylbenzoate synthase resulting in the release of a water molecule and a 2-succinylbenzoate. This compound then interacts with a coenzyme A and an ATP through a o-succinylbenzoate CoA ligase resulting in the release of a diphosphate, a AMP and a succinylbenzoyl-CoA. The latter compound interacts with a hydrogen ion through a 1,4-dihydroxy-2-naphthoyl-CoA synthase resulting in the release of a water molecule or a 1,4-dihydroxy-2-naphthoyl-CoA. This compound then interacts with water through a 1,4-dihydroxy-2-naphthoyl-CoA thioesterase resulting in the release of a coenzyme A, a hydrogen ion and a 1,4-dihydroxy-2-naphthoate.
The 1,4-dihydroxy-2-naphthoate can interact with either farnesylfarnesylgeranyl-PP or octaprenyl diphosphate and a hydrogen ion through a 1,4-dihydroxy-2-naphthoate octaprenyltransferase resulting in a release of a carbon dioxide, a pyrophosphate and a demethylmenaquinol-8. This compound then interacts with SAM through a bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase and S-adenosylmethionine:2-DMK methyltransferase resulting in a hydrogen ion, a s-adenosyl-L-homocysteine and a menaquinol.PW001897MetabolicPorphyrin metabolismThe metabolism of porphyrin begins with with glutamic acid being processed by an ATP-driven glutamyl-tRNA synthetase by interacting with hydrogen ion and tRNA(Glu), resulting in amo, pyrophosphate and L-glutamyl-tRNA(Glu) Glutamic acid. Glutamic acid can be obtained as a result of L-glutamate metabolism pathway, glutamate / aspartate : H+ symporter GltP, glutamate:sodium symporter or a glutamate / aspartate ABC transporter .
L-glutamyl-tRNA(Glu) Glutamic acid interacts with a NADPH glutamyl-tRNA reductase resulting in a NADP, a tRNA(Glu) and a (S)-4-amino-5-oxopentanoate.
This compound interacts with a glutamate-1-semialdehyde aminotransferase resulting a 5-aminolevulinic acid. This compound interacts with a porphobilinogen synthase resulting in a hydrogen ion, water and porphobilinogen. The latter compound interacts with water resulting in hydroxymethylbilane synthase resulting in ammonium, and hydroxymethylbilane.
Hydroxymethylbilane can either be dehydrated to produce uroporphyrinogen I or interact with a uroporphyrinogen III synthase resulting in a water molecule and a uroporphyrinogen III.
Uroporphyrinogen I interacts with hydrogen ion through a uroporphyrinogen decarboxylase resulting in a carbon dioxide and a coproporphyrinogen I
Uroporphyrinogen III can be metabolized into precorrin by interacting with a S-adenosylmethionine through a siroheme synthase resulting in hydrogen ion, an s-adenosylhomocysteine and a precorrin-1. On the other hand, Uroporphyrinogen III interacts with hydrogen ion through a uroporphyrinogen decarboxylase resulting in a carbon dioxide and a Coproporphyrinogen III.
Precorrin-1 reacts with a S-adenosylmethionine through a siroheme synthase resulting in a S-adenosylhomocysteine and a Precorrin-2. The latter compound is processed by a NAD dependent uroporphyrin III C-methyltransferase [multifunctional] resulting in a NADH and a sirohydrochlorin. This compound then interacts with Fe 2+
uroporphyrin III C-methyltransferase [multifunctional] resulting in a hydrogen ion and a siroheme. The siroheme is then processed in sulfur metabolism pathway.
Uroporphyrinogen III can be processed in anaerobic or aerobic condition.
Anaerobic:
Uroporphyrinogen III interacts with an oxygen molecule, a hydrogen ion through a coproporphyrinogen III oxidase resulting in water, carbon dioxide and protoporphyrinogen IX. The latter compound then interacts with an 3 oxygen molecule through a protoporphyrinogen oxidase resulting in 3 hydrogen peroxide and a Protoporphyrin IX
Aerobic:
Uroporphyrinogen III reacts with S-adenosylmethionine through a coproporphyrinogen III dehydrogenase resulting in carbon dioxide, 5-deoxyadenosine, L-methionine and protoporphyrinogen IX. The latter compound interacts with a meanquinone through a protoporphyrinogen oxidase resulting in protoporphyrin IX.
The protoporphyrin IX interacts with Fe 2+ through a ferrochelatase resulting in a hydrogen ion and a ferroheme b. The ferroheme b can either be incorporated into the oxidative phosphorylation as a cofactor of the enzymes involved in that pathway or it can interact with hydrogen peroxide through a catalase HPII resulting in a heme D. Heme D can then be incorporated into the oxidative phosphyrlation pathway as a cofactor of the enzymes involved in that pathway. Ferroheme b can also interact with water and a farnesyl pyrophosphate through a heme O synthase resulting in a release of pyrophosphate and heme O. Heme O is then incorporated into the Oxidative phosphorylation pathway.
PW000936MetabolicQuorum SensingBacterial Autoinducer 2 (AI-2) mediates the quorum sensing 2 system. AI-2 is catalyzed by the luxS enzyme. This enzyme is found in E.coli and S.typhimurium.
In E. coli and most pathogenic bacteria that form AI-2 are spontaneous transformations that include cyclization to (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one and hydration to the final autoinducer (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran. This product is released from the cell through the AI-2 transporter (tqsA).
As the level of AI-2 increases, other cells detect it and import it through the autoinducer-2 ABC transporter (lsrACDB). AI-2 is then degraded in the cells by phosphorylating the AI-2 which is then isomerized to P-HPD which follows by the transfer of and acetyl group to coenzyme A and releases dihydroxyacetone phosphatePW000836SignalingSecondary Metabolites: Ubiquinol biosynthesisThe biosynthesis of ubiquinol starts the interaction of 4-hydroxybenzoic acid interacting with an octaprenyl diphosphate. The former compound comes from the chorismate interacting with a chorismate lyase resulting in the release of a pyruvic acid and a 4-hydroxybenzoic acid. On the other hand, the latter compound, octaprenyl diphosphate is the result of a farnesyl pyrophosphate interacting with an isopentenyl pyrophosphate through an octaprenyl diphosphate synthase resulting in the release of a pyrophosphate and an octaprenyl diphosphate.
The 4-hydroxybenzoic acid interacts with octaprenyl diphosphate through a 4-hydroxybenzoate octaprenyltransferase resulting in the release of a pyrophosphate and a 3-octaprenyl-4-hydroxybenzoate. The latter compound then interacts with a hydrogen ion through a 3-octaprenyl-4-hydroxybenzoate carboxy-lyase resulting in the release of a carbon dioxide and a 2-octaprenylphenol. The latter compound interacts with an oxygen molecule and a hydrogen ion through a NADPH driven 2-octaprenylphenol hydroxylase resulting in a NADP, a water molecule and a 2-octaprenyl-6-hydroxyphenol.
The 2-octaprenyl-6-hydroxyphenol interacts with an S-adenosylmethionine through a bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase resulting in the release of a hydrogen ion, an s-adenosylhomocysteine and a 2-methoxy-6-(all-trans-octaprenyl)phenol. The latter compound then interacts with an oxygen molecule and a hydrogen ion through a NADPH driven 2-octaprenyl-6-methoxyphenol hydroxylase resulting in a NADP, a water molecule and a 2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol.
The latter compound interacts with a S-adenosylmethionine through a bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase and S-adenosylmethionine:2-DMK methyltransferase resulting in a s-adenosylhomocysteine, a hydrogen ion and a 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol. The 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol. interacts with a reduced acceptor, an oxygen molecule through a 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase resulting in the release of a water molecule, an oxidized electron acceptor and a 3-demethylubiquinol-8. The latter compound then interacts with a S-adenosylmethionine through a bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase resulting in a hydrogen ion, a S-adenosylhomocysteine and a ubiquinol 8.
PW000981MetabolicSecondary Metabolites: Ubiquinol biosynthesis 2The biosynthesis of ubiquinol starts the interaction of 4-hydroxybenzoic acid interacting with an octaprenyl diphosphate. The former compound comes from the chorismate interacting with a chorismate lyase resulting in the release of a pyruvic acid and a 4-hydroxybenzoic acid. On the other hand, the latter compound, octaprenyl diphosphate is the result of a farnesyl pyrophosphate interacting with an isopentenyl pyrophosphate through an octaprenyl diphosphate synthase resulting in the release of a pyrophosphate and an octaprenyl diphosphate. The 4-hydroxybenzoic acid interacts with octaprenyl diphosphate through a 4-hydroxybenzoate octaprenyltransferase resulting in the release of a pyrophosphate and a 3-octaprenyl-4-hydroxybenzoate. The latter compound then interacts with a hydrogen ion through a 3-octaprenyl-4-hydroxybenzoate carboxy-lyase resulting in the release of a carbon dioxide and a 2-octaprenylphenol. The latter compound interacts with an oxygen molecule and a hydrogen ion through a NADPH driven 2-octaprenylphenol hydroxylase resulting in a NADP, a water molecule and a 2-octaprenyl-6-hydroxyphenol. The 2-octaprenyl-6-hydroxyphenol interacts with an S-adenosylmethionine through a bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase resulting in the release of a hydrogen ion, an s-adenosylhomocysteine and a 2-methoxy-6-(all-trans-octaprenyl)phenol. The latter compound then interacts with an oxygen molecule and a hydrogen ion through a NADPH driven 2-octaprenyl-6-methoxyphenol hydroxylase resulting in a NADP, a water molecule and a 2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol. The latter compound interacts with a S-adenosylmethionine through a bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase and S-adenosylmethionine:2-DMK methyltransferase resulting in a s-adenosylhomocysteine, a hydrogen ion and a 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol. The 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol. interacts with a reduced acceptor, an oxygen molecule through a 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase resulting in the release of a water molecule, an oxidized electron acceptor and a 3-demethylubiquinol-8. The latter compound then interacts with a S-adenosylmethionine through a bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase resulting in a hydrogen ion, a S-adenosylhomocysteine and a ubiquinol 8.PW002036MetabolicCyclopropane Fatty Acid (CFA) BiosynthesisCyclopropane fatty acyl phospholipid synthase catalyzes the modification of acyl chains of phospholipid bilayers through methylenation (using S-adenosyl-L-methionine) of an unsaturated bond to their cyclopropane derivatives. It is one of the few enzymes known to act on the nonpolar portion of phospholipids dispersed in a vesicle. The enzyme acts on the double bond of a phospholipid unsaturated fatty acid residue, which must be nine to eleven carbon atoms removed from the glycerol backbone of the molecule.
S-adenosyl-L-methionine is the methyl donor for formation of the methylene moiety. CFA synthase exhibits activity toward phosphatidylglycerol, phosphatidylethanolamine, cardiolipin, and also toward phosphatidylcholine. (EcoCyc)PW002109MetabolicS-adenosyl-L-methionine cycleThe S-adenosyl-L-methionine cycle starts with S-adenosyl-L-methionine reacting with (a demethylated methyl donor ) dimethylglycine resulting in the release of a hydrogen ion, a betain (a methylated methyl donor) and a S-adenosyl-L-homocysteine. The s-adenosyl-L-homocysteine reacts with a water molecule through a S-adenosylhomocysteine nucleosidase resulting in the release of a adenine and a ribosyl-L-homocysteine. This compound in turn reacts with a s-ribosylhomocysteine lyase resulting in the release of a l-homocysteine and a autoinducer 2. The L-homocysteine reacts with a N5-methyl-tetrahydropteroyl tri-L-glutamate through a methionine synthase resulting in the release of a tetrahydropteroyl tri-L-glutamate and a methione. The methionine in turn reacts with a water molecule and ATP molecule through a methionine adenosyltransferase resulting in the release of a diphosphate, a phosphate and a s-adenosyl-L-methionine.PW002080Metabolic<i>S</i>-adenosyl-L-methionine cycle IPWY-6151autoinducer AI-2 biosynthesis IPWY-61537-keto-8-aminopelargonate biosynthesis IPWY-6519ubiquinol-8 biosynthesis (prokaryotic)PWY-6708siroheme biosynthesisPWY-5194cyclopropane fatty acid (CFA) biosynthesisPWY0-541menaquinol-8 biosynthesisMENAQUINONESYN-PWYSpecdb::CMs23475Specdb::CMs37852Specdb::CMs135712Specdb::CMs143446Specdb::CMs1081911Specdb::CMs1081913Specdb::CMs1081914Specdb::CMs1081916Specdb::CMs1081918Specdb::CMs1081920Specdb::CMs1081922Specdb::CMs1081924Specdb::CMs1081926Specdb::CMs1081928Specdb::CMs1081930Specdb::CMs1081932Specdb::CMs1081933Specdb::CMs1081935Specdb::CMs1081937Specdb::CMs1081939Specdb::CMs1081941Specdb::CMs1081943Specdb::CMs1081945Specdb::CMs1081947Specdb::CMs1081949Specdb::NmrOneD1613Specdb::NmrOneD4788Specdb::NmrOneD4789Specdb::NmrOneD8022Specdb::NmrOneD8023Specdb::NmrOneD8024Specdb::NmrOneD8025Specdb::NmrOneD8026Specdb::NmrOneD8027Specdb::NmrOneD8028Specdb::NmrOneD8029Specdb::NmrOneD8030Specdb::NmrOneD8031Specdb::NmrOneD8032Specdb::NmrOneD8033Specdb::NmrOneD8034Specdb::NmrOneD8035Specdb::NmrOneD8036Specdb::NmrOneD8037Specdb::NmrOneD8038Specdb::NmrOneD8039Specdb::NmrOneD8040Specdb::NmrOneD8041Specdb::MsMs6260Specdb::MsMs6261Specdb::MsMs6262Specdb::MsMs6263Specdb::MsMs6264Specdb::MsMs6265Specdb::MsMs6266Specdb::MsMs6267Specdb::MsMs6269Specdb::MsMs438820Specdb::MsMs438821Specdb::MsMs438822Specdb::MsMs438859Specdb::MsMs438860Specdb::MsMs438861Specdb::MsMs439105Specdb::MsMs2232539Specdb::MsMs6252Specdb::MsMs6253Specdb::MsMs6254Specdb::MsMs6255Specdb::MsMs6256Specdb::MsMs6257Specdb::MsMs6258Specdb::MsMs6259Specdb::NmrTwoD1049Specdb::NmrTwoD1554HMDB00939439155388301C0002116680ADENOSYL-HOMO-CYSSAHSAHKeseler, I. 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Annu Rev Nutr. 1992;12:59-79.1354465Mulder C, Schoonenboom NS, Jansen EE, Verhoeven NM, van Kamp GJ, Jakobs C, Scheltens P: The transmethylation cycle in the brain of Alzheimer patients. Neurosci Lett. 2005 Sep 30;386(2):69-71.16040194Delabar U, Kloor D, Luippold G, Muhlbauer B: Simultaneous determination of adenosine, S-adenosylhomocysteine and S-adenosylmethionine in biological samples using solid-phase extraction and high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1999 Mar 19;724(2):231-8.10219663Hermes M, von Hippel S, Osswald H, Kloor D: S-adenosylhomocysteine metabolism in different cell lines: effect of hypoxia and cell density. Cell Physiol Biochem. 2005;15(5):233-44.15956786Weir DG, Molloy AM, Keating JN, Young PB, Kennedy S, Kennedy DG, Scott JM: Correlation of the ratio of S-adenosyl-L-methionine to S-adenosyl-L-homocysteine in the brain and cerebrospinal fluid of the pig: implications for the determination of this methylation ratio in human brain. Clin Sci (Lond). 1992 Jan;82(1):93-7.1310924Wagner C, Koury MJ: S-Adenosylhomocysteine: a better indicator of vascular disease than homocysteine? Am J Clin Nutr. 2007 Dec;86(6):1581-5.18065573Herrmann W, Obeid R: Biomarkers of folate and vitamin B(12) status in cerebrospinal fluid. Clin Chem Lab Med. 2007;45(12):1614-20.17892439Holy, Antonin; Rosenberg, Ivan. Studies on S-adenosyl-L-homocysteine hydrolase. Part XV. An improved synthesis of S-adenosyl-L-homocysteine and related compounds. Collection of Czechoslovak Chemical Communications (1985), 50(7), 1514-18.http://hmdb.ca/system/metabolites/msds/000/000/845/original/HMDB00939.pdf?1358462988Chemotaxis protein methyltransferaseP07364CHER_ECOLIcheRhttp://ecmdb.ca/proteins/P07364.xmlType I restriction enzyme EcoKI M proteinP08957T1MK_ECOLIhsdMhttp://ecmdb.ca/proteins/P08957.xmlPutative uroporphyrinogen-III C-methyltransferaseP09127HEMX_ECOLIhemXhttp://ecmdb.ca/proteins/P09127.xmlProtein-L-isoaspartate O-methyltransferaseP0A7A5PIMT_ECOLIpcmhttp://ecmdb.ca/proteins/P0A7A5.xmltRNA (guanine-N(1)-)-methyltransferaseP0A873TRMD_ECOLItrmDhttp://ecmdb.ca/proteins/P0A873.xmltRNA (guanine-N(7)-)-methyltransferaseP0A8I5TRMB_ECOLItrmBhttp://ecmdb.ca/proteins/P0A8I5.xmlCyclopropane-fatty-acyl-phospholipid synthaseP0A9H7CFA_ECOLIcfahttp://ecmdb.ca/proteins/P0A9H7.xmlRibosomal RNA small subunit methyltransferase DP0ADX9RSMD_ECOLIrsmDhttp://ecmdb.ca/proteins/P0ADX9.xmlSiroheme synthaseP0AEA8CYSG_ECOLIcysGhttp://ecmdb.ca/proteins/P0AEA8.xmlDNA-cytosine methyltransferaseP0AED9DCM_ECOLIdcmhttp://ecmdb.ca/proteins/P0AED9.xmlDNA adenine methylaseP0AEE8DMA_ECOLIdamhttp://ecmdb.ca/proteins/P0AEE8.xml5'-methylthioadenosine/S-adenosylhomocysteine nucleosidaseP0AF12MTNN_ECOLImtnNhttp://ecmdb.ca/proteins/P0AF12.xmltRNA guanosine-2'-O-methyltransferaseP0AGJ2TRMH_ECOLItrmHhttp://ecmdb.ca/proteins/P0AGJ2.xml3-demethylubiquinone-9 3-methyltransferaseP17993UBIG_ECOLIubiGhttp://ecmdb.ca/proteins/P17993.xmltRNA (uracil-5-)-methyltransferaseP23003TRMA_ECOLItrmAhttp://ecmdb.ca/proteins/P23003.xmlUncharacterized adenine-specific methylase yhdJP28638YHDJ_ECOLIyhdJhttp://ecmdb.ca/proteins/P28638.xmlRibosomal RNA large subunit methyltransferase AP36999RLMA_ECOLIrlmAhttp://ecmdb.ca/proteins/P36999.xmlUncharacterized adenine-specific methylase yfcBP39199YFCB_ECOLIyfcBhttp://ecmdb.ca/proteins/P39199.xmlRibosomal RNA small subunit methyltransferase CP39406RSMC_ECOLIrsmChttp://ecmdb.ca/proteins/P39406.xmlRibosomal RNA large subunit methyltransferase GP42596RLMG_ECOLIrlmGhttp://ecmdb.ca/proteins/P42596.xmlRibosomal RNA large subunit methyltransferase FP75782RLMF_ECOLIrlmFhttp://ecmdb.ca/proteins/P75782.xmlTrans-aconitate 2-methyltransferaseP76145TAM_ECOLItamhttp://ecmdb.ca/proteins/P76145.xmltRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein mnmCP77182MNMC_ECOLImnmChttp://ecmdb.ca/proteins/P77182.xmlHomocysteine S-methyltransferaseQ47690MMUM_ECOLImmuMhttp://ecmdb.ca/proteins/Q47690.xmlUbiquinone/menaquinone biosynthesis methyltransferase ubiEP0A887UBIE_ECOLIubiEhttp://ecmdb.ca/proteins/P0A887.xmlBiotin synthesis protein BioCP12999BIOC_ECOLIbioChttp://ecmdb.ca/proteins/P12999.xml23S rRNA mG2445 methyltransferase, SAM-dependentP75864rlmLhttp://ecmdb.ca/proteins/P75864.xmlProtein methyltransferase hemKP0ACC1HEMK_ECOLIhemKhttp://ecmdb.ca/proteins/P0ACC1.xml23S rRNA (guanosine-2'-O-)-methyltransferase rlmBP63177RLMB_ECOLIrlmBhttp://ecmdb.ca/proteins/P63177.xml23S rRNA (uracil-5-)-methyltransferase rumBP75817RUMB_ECOLIrumBhttp://ecmdb.ca/proteins/P75817.xml23S rRNA (uracil-5-)-methyltransferase rumAP55135RUMA_ECOLIrumAhttp://ecmdb.ca/proteins/P55135.xmlRibosomal RNA large subunit methyltransferase EP0C0R7RLME_ECOLIrlmEhttp://ecmdb.ca/proteins/P0C0R7.xmlRibosomal RNA large subunit methyltransferase HP0A8I8RLMH_ECOLIrlmHhttp://ecmdb.ca/proteins/P0A8I8.xmlRibosomal RNA large subunit methyltransferase IP75876RLMI_ECOLIrlmIhttp://ecmdb.ca/proteins/P75876.xmlRibosomal RNA large subunit methyltransferase MP0ADR6RLMM_ECOLIrlmMhttp://ecmdb.ca/proteins/P0ADR6.xmlRibosomal RNA large subunit methyltransferase NP36979RLMN_ECOLIrlmNhttp://ecmdb.ca/proteins/P36979.xmlRibosomal RNA small subunit methyltransferase AP06992RSMA_ECOLIrsmAhttp://ecmdb.ca/proteins/P06992.xmlRibosomal RNA small subunit methyltransferase BP36929RSMB_ECOLIrsmBhttp://ecmdb.ca/proteins/P36929.xmlRibosomal RNA small subunit methyltransferase EP0AGL7RSME_ECOLIrsmEhttp://ecmdb.ca/proteins/P0AGL7.xmlRibosomal RNA small subunit methyltransferase FP76273RSMF_ECOLIrsmFhttp://ecmdb.ca/proteins/P76273.xmlRibosomal RNA small subunit methyltransferase GP0A6U5RSMG_ECOLIrsmGhttp://ecmdb.ca/proteins/P0A6U5.xmlRibosomal RNA small subunit methyltransferase HP60390RSMH_ECOLIrsmHhttp://ecmdb.ca/proteins/P60390.xmlRibosomal RNA small subunit methyltransferase IP67087RSMI_ECOLIrsmIhttp://ecmdb.ca/proteins/P67087.xmlUPF0341 protein yhiQP68567YHIQ_ECOLIyhiQhttp://ecmdb.ca/proteins/P68567.xmltRNA (cytidine/uridine-2'-O-)-methyltransferase trmJP0AE01TRMJ_ECOLItrmJhttp://ecmdb.ca/proteins/P0AE01.xmlUncharacterized tRNA/rRNA methyltransferase yibKP0AGJ7YIBK_ECOLIyibKhttp://ecmdb.ca/proteins/P0AGJ7.xmltRNA (adenine-N(6)-)-methyltransferaseP31825TRMN6_ECOLIyfiChttp://ecmdb.ca/proteins/P31825.xmltRNA-2-methylthio-N(6)-dimethylallyladenosine synthaseP0AEI1MIAB_ECOLImiaBhttp://ecmdb.ca/proteins/P0AEI1.xmlRibosomal protein S12 methylthiotransferase RimOP0AEI4RIMO_ECOLIrimOhttp://ecmdb.ca/proteins/P0AEI4.xml2 S-Adenosylmethionine + Uroporphyrinogen III >2 S-Adenosylhomocysteine + Precorrin 2 + Hydrogen ionR03194S-Adenosylhomocysteine + Water <> Adenine + S-Ribosyl-L-homocysteineR00194ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXNS-Adenosylmethionine + L-Homocysteine + S-Methylmethionine <> S-Adenosylhomocysteine + Hydrogen ion + L-MethionineR00650HOMOCYSTEINE-S-METHYLTRANSFERASE-RXNS-Adenosylmethionine + Malonyl-CoA > S-Adenosylhomocysteine + malonyl-CoA methyl esterRXN-11475trans-Aconitic acid + S-Adenosylmethionine > E-3-Carboxy-2-pentenedioate 6-methyl ester + S-AdenosylhomocysteineRXN0-24412 S-Adenosylmethionine + PE(14:0/14:0) >2 S-Adenosylhomocysteine + Cyclopropane phosphatidylethanolamine (dihexadec-9,10-cyclo-anoyl, N-C16:0 cyclo) +2 Hydrogen ion2 S-Adenosylmethionine + PE(14:0/14:0) >2 S-Adenosylhomocysteine + Cyclopropane phosphatidylethanolamine (dioctadec-11,12-cyclo-anoyl, N-C18:0 cyclo) +2 Hydrogen ion2 S-Adenosylmethionine + PG(16:1(9Z)/16:1(9Z)) >2 S-Adenosylhomocysteine + Cyclopropane phosphatidylglycerol (dihexadec-9,10-cyclo-anoyl, N-C16:0 cyclo) +2 Hydrogen ion2 S-Adenosylmethionine + PG(18:1(11Z)/18:1(11Z)) >2 S-Adenosylhomocysteine + Cyclopropane phosphatidylglycerol (dioctadec-11,12-cyclo-anoyl, N-C18:0 cyclo) +2 Hydrogen ion2-Octaprenyl-6-hydroxyphenol + S-Adenosylmethionine > 2-Octaprenyl-6-methoxyphenol + S-Adenosylhomocysteine + Hydrogen ionR049882-OCTAPRENYL-6-OHPHENOL-METHY-RXN2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-Adenosylmethionine > S-Adenosylhomocysteine + Hydrogen ion + Ubiquinol-82-Demethylmenaquinol 8 + S-Adenosylmethionine > S-Adenosylhomocysteine + Hydrogen ion + Menaquinol 8ADOMET-DMK-METHYLTRANSFER-RXN2-Octaprenyl-6-methoxy-1,4-benzoquinol + S-Adenosylmethionine > 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + S-Adenosylhomocysteine + Hydrogen ion2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXNS-Adenosylmethionine + L-Homocysteine <> S-Adenosylhomocysteine + L-MethionineR00650HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN2 S-Adenosylmethionine + Uroporphyrinogen III <>2 S-Adenosylhomocysteine + Precorrin 2R03194S-Adenosylmethionine + DNA cytosine <> S-Adenosylhomocysteine + DNA 5-methylcytosineR048582-Octaprenyl-6-hydroxyphenol + S-Adenosylmethionine <> 2-Octaprenyl-6-methoxyphenol + S-AdenosylhomocysteineR049882-octaprenyl-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine <> 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-AdenosylhomocysteineR049902-Demethylmenaquinone 8 + S-Adenosylmethionine <> Menaquinone + S-AdenosylhomocysteineR049932-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine <> Ubiquinone-8 + S-AdenosylhomocysteineR056142-Phytyl-1,4-naphthoquinone + S-Adenosylmethionine <> Phylloquinone + S-AdenosylhomocysteineR06859S-Adenosylmethionine + rRNA <> S-Adenosylhomocysteine + rRNA containing N6-methyladenineR07232S-Adenosylmethionine + rRNA <> S-Adenosylhomocysteine + rRNA containing N1-methylguanineR07233S-Adenosylmethionine + rRNA <> S-Adenosylhomocysteine + rRNA containing N2-methylguanineR072342-Polyprenyl-6-hydroxyphenol + S-Adenosylmethionine <> 2-Polyprenyl-6-methoxyphenol + S-AdenosylhomocysteineR087692-Polyprenyl-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine <> 2-Polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-AdenosylhomocysteineR087742-Polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine <> Ubiquinone-1 + S-AdenosylhomocysteineR08781Demethylmenaquinol + S-Adenosylmethionine + Demethylmenaquinol <> Menaquinol 6 + S-AdenosylhomocysteineR09736S-Adenosylmethionine + precorrin-1 > S-Adenosylhomocysteine + Precorrin 2RXN-8675S-Adenosylmethionine + a [protein]-L-glutamine > Hydrogen ion + S-Adenosylhomocysteine + a [protein]-N<sup>5</sup>-methyl-L-glutamineRXN0-1241tellurite + S-Adenosylmethionine methylated tellurite + S-AdenosylhomocysteineRXN0-6576S-Adenosylmethionine + Uroporphyrinogen III <> S-Adenosylhomocysteine + precorrin-1 + Hydrogen ionUROPORIIIMETHYLTRANSA-RXNS-Adenosylmethionine + a [protein]-L-β-isoaspartate > S-Adenosylhomocysteine + a protein L-β-isoaspartate α-methyl ester + Hydrogen ion2.1.1.77-RXNa phospholipid olefinic fatty acid + S-Adenosylmethionine > a phospholipid cyclopropane fatty acid + S-Adenosylhomocysteine + Hydrogen ion2.1.1.79-RXNS-Ribosyl-L-homocysteine + Adenine < S-Adenosylhomocysteine + WaterR00194ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine > Hydrogen ion + Ubiquinol-8 + S-AdenosylhomocysteineDHHB-METHYLTRANSFER-RXNL-Homocysteine + S-Adenosylmethionine Hydrogen ion + L-Methionine + S-AdenosylhomocysteineHOMOCYSTEINE-S-METHYLTRANSFERASE-RXNS-Adenosylmethionine + a demethylated methyl acceptor > S-Adenosylhomocysteine + a methylated methyl acceptorRXN-7605N-6-isopentyl adenosine-37 tRNA + S-Adenosylmethionine + <i>S</i>-sulfanyl-[acceptor] 2-methylthio-N-6-isopentyl adenosine-37 tRNA + S-Adenosylhomocysteine + L-Methionine + 5'-Deoxyadenosine + an unsulfurated sulfur acceptor + Hydrogen ionRXN0-5063a guanine<sup>1516</sup> in 16S rRNA + S-Adenosylmethionine > an <i>N</i><sup>2</sup>-methylguanine<sup>1516</sup> in 16S rRNA + S-Adenosylhomocysteine + Hydrogen ionRXN0-6731guanine<sup>2069</sup> in 23S rRNA + S-Adenosylmethionine > N<sup>7</sup>-methylguanine<sup>2069</sup> in 23S rRNA + S-AdenosylhomocysteineRXN0-6950S-adenosyl-L-methionine + Malonyl-CoA > S-Adenosylhomocysteine + malonyl-CoA methyl esterS-adenosyl-L-methionine + phospholipid olefinic fatty acid > S-Adenosylhomocysteine + phospholipid cyclopropane fatty acidS-adenosyl-L-methionine + protein L-glutamate > S-Adenosylhomocysteine + protein L-glutamate methyl esterS-adenosyl-L-methionine + Uroporphyrinogen III > S-Adenosylhomocysteine + Precorrin-1S-adenosyl-L-methionine + Precorrin-1 > S-Adenosylhomocysteine + Precorrin-2S-adenosyl-L-methionine + DNA > S-Adenosylhomocysteine + DNA containing 5-methylcytosineS-adenosyl-L-methionine + DNA adenine > S-Adenosylhomocysteine + DNA 6-methylaminopurineS-adenosyl-L-methionine + tRNA > S-Adenosylhomocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylateS-Adenosylhomocysteine + Water > S-Ribosyl-L-homocysteine + AdenineS-adenosyl-L-methionine + protein L-isoaspartate > S-Adenosylhomocysteine + protein L-isoaspartate alpha-methyl esterS-adenosyl-L-methionine + glutamine in ribosomal protein L3 > S-Adenosylhomocysteine + N5-methylglutamine in ribosomal protein L3S-adenosyl-L-methionine + glutamine in release factor > S-Adenosylhomocysteine + N5-methylglutamine in release factorS-adenosyl-L-methionine + guanine(745) in 23S rRNA > S-Adenosylhomocysteine + N(1)-methylguanine(745) in 23S rRNAS-adenosyl-L-methionine + guanosine(2251) in 23S rRNA > S-Adenosylhomocysteine + 2'-O-methylguanosine(2251) in 23S rRNAS-adenosyl-L-methionine + uracil(747) in 23S rRNA > S-Adenosylhomocysteine + 5-methyluracil(747) in 23S rRNAS-adenosyl-L-methionine + uracil(1939) in 23S rRNA > S-Adenosylhomocysteine + 5-methyluracil(1939) in 23S rRNAS-adenosyl-L-methionine + uridine(2552) in 23S rRNA > S-Adenosylhomocysteine + 2'-O-methyluridine(2552) in 23S rRNAS-adenosyl-L-methionine + adenine(1618) in 23S rRNA > S-Adenosylhomocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNAS-adenosyl-L-methionine + guanine(1835) in 23S rRNA > S-Adenosylhomocysteine + N(2)-methylguanine(1835) in 23S rRNAS-adenosyl-L-methionine + rRNA > S-Adenosylhomocysteine + rRNA containing N3-methylpseudouridineS-adenosyl-L-methionine + pseudouridine(1915) in 23S rRNA > S-Adenosylhomocysteine + N(3)-methylpseudouridine(1915) in 23S rRNAS-adenosyl-L-methionine + cytosine(1962) in 23S rRNA > S-Adenosylhomocysteine + 5-methylcytosine(1962) in 23S rRNAS-adenosyl-L-methionine + guanine(2445) in 23S rRNA > S-Adenosylhomocysteine + N(2)-methylguanine(2445) in 23S rRNAS-adenosyl-L-methionine + cytidine(2498) in 23S rRNA > S-Adenosylhomocysteine + 2'-O-methylcytidine(2498) in 23S rRNA2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA > S-Adenosylhomocysteine + L-Methionine + 5'-Deoxyadenosine + 2-methyladenine(2503) in 23S rRNA4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA >4 S-Adenosylhomocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNAS-adenosyl-L-methionine + cytosine(967) in 16S rRNA > S-Adenosylhomocysteine + 5-methylcytosine(967) in 16S rRNAS-adenosyl-L-methionine + guanine(1207) in 16S rRNA > S-Adenosylhomocysteine + N(2)-methylguanine(1207) in 16S rRNAS-adenosyl-L-methionine + guanine(966) in 16S rRNA > S-Adenosylhomocysteine + N(2)-methylguanine(966) in 16S rRNAS-adenosyl-L-methionine + uracil(1498) in 16S rRNA > S-Adenosylhomocysteine + N(3)-methyluracil(1498) in 16S rRNAS-adenosyl-L-methionine + cytosine(1407) in 16S rRNA > S-Adenosylhomocysteine + 5-methylcytosine(1407) in 16S rRNAS-adenosyl-L-methionine + guanine(527) in 16S rRNA > S-Adenosylhomocysteine + N(7)-methylguanine(527) in 16S rRNAS-adenosyl-L-methionine + cytosine(1402) in 16S rRNA > S-Adenosylhomocysteine + N(4)-methylcytosine(1402) in 16S rRNAS-adenosyl-L-methionine + cytidine(1402) in 16S rRNA > S-Adenosylhomocysteine + 2'-O-methylcytidine(1402) in 16S rRNAS-adenosyl-L-methionine + guanine(1516) in 16S rRNA > S-Adenosylhomocysteine + N(2)-methylguanine(1516) in 16S rRNAS-adenosyl-L-methionine + trans-Aconitic acid > S-Adenosylhomocysteine + (E)-3-(Methoxycarbonyl)pent-2-enedioateS-adenosyl-L-methionine + uridine(54) in tRNA > S-Adenosylhomocysteine + 5-methyluridine(54) in tRNAS-adenosyl-L-methionine + guanine(46) in tRNA > S-Adenosylhomocysteine + N(7)-methylguanine(46) in tRNAS-adenosyl-L-methionine + guanine(37) in tRNA > S-Adenosylhomocysteine + N(1)-methylguanine(37) in tRNAS-adenosyl-L-methionine + guanosine(18) in tRNA > S-Adenosylhomocysteine + 2'-O-methylguanosine(18) in tRNAS-adenosyl-L-methionine + cytidine(32) in tRNA > S-Adenosylhomocysteine + 2'-O-methylcytidine(32) in tRNAS-adenosyl-L-methionine + uridine(32) in tRNA > S-Adenosylhomocysteine + 2'-O-methyluridine(32) in tRNAS-adenosyl-L-methionine + cytidine(34) in tRNA > S-Adenosylhomocysteine + 2'-O-methylcytidine(34) in tRNAS-adenosyl-L-methionine + 5-carboxymethylaminomethyluridine(34) in tRNA(Leu) > S-Adenosylhomocysteine + 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu)S-adenosyl-L-methionine + adenine(37) in tRNA(1)(Val) > S-Adenosylhomocysteine + N(6)-methyladenine(37) in tRNA(1)(Val)A demethylmenaquinone + S-adenosyl-L-methionine > Menaquinol 6 + S-AdenosylhomocysteineS-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol > S-Adenosylhomocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinolS-adenosyl-L-methionine + 3-demethylubiquinone-n > S-Adenosylhomocysteine + ubiquinone-nS-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol > S-Adenosylhomocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenolS-Adenosylmethionine <> S-AdenosylhomocysteineR02917 S-Adenosylmethionine + trans-Aconitic acid <> S-Adenosylhomocysteine + E-3-Carboxy-2-pentenedioate 6-methyl esterR05763 S-Adenosylmethionine + Phospholipid olefinic fatty acid <> S-Adenosylhomocysteine + Phospholipid cyclopropane fatty acidR03411 S-Adenosylmethionine + tRNA containing 5-aminomethyl-2-thiouridine <> S-Adenosylhomocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylateR00601 S-Adenosylmethionine + DNA adenine <> S-Adenosylhomocysteine + DNA 6-methylaminopurineR02961 2 S-Adenosylmethionine + Uroporphyrinogen III + Precorrin-1 <>2 S-Adenosylhomocysteine + Precorrin 2R03194 2 S-Adenosylmethionine <> S-Adenosylhomocysteine +2 L-Methionine + 5'-DeoxyadenosineR10645 2 S-Adenosylmethionine + Reduced acceptor <> S-Adenosylhomocysteine +2 L-Methionine + 5'-DeoxyadenosineR10652 S-Adenosylmethionine + Protein glutamate <> S-Adenosylhomocysteine + Protein glutamate methyl esterR02623 S-Adenosylmethionine <> S-Adenosylhomocysteine + DNA 5-methylcytosineR00380 S-Adenosylmethionine + Protein L-isoaspartate <> S-Adenosylhomocysteine + Protein L-isoaspartate methyl esterR04190 S-Adenosylmethionine + tRNA <> S-Adenosylhomocysteine + tRNA containing N6-methyladenineR00599 S-Adenosylhomocysteine + Water > Adenine + S-ribosyl-L-homocysteine + S-ribosyl-L-homocysteinePW_R003067a malonyl-[acp] + S-adenosyl-L-methionine > S-Adenosylhomocysteine + a malonyl-[acp] methyl esterPW_R002455Uroporphyrinogen III + S-adenosyl-L-methionine > Hydrogen ion + S-Adenosylhomocysteine + Precorrin-1PW_R0034892-Octaprenyl-6-hydroxyphenol + S-adenosyl-L-methionine + 2-Octaprenyl-6-hydroxyphenol > Hydrogen ion + S-Adenosylhomocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenolPW_R0037193-demethylubiquinol-8 + S-adenosyl-L-methionine > Hydrogen ion + S-Adenosylhomocysteine + Ubiquinol 8 + Ubiquinol-8PW_R0037232-Octaprenyl-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine > S-Adenosylhomocysteine + Hydrogen ion + 6-Methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinolPW_R0037212-Demethylmenaquinol 8 + S-adenosyl-L-methionine > Hydrogen ion + S-Adenosylhomocysteine + Menaquinol 8PW_R005240S-Adenosylhomocysteine + Water > AdeninePW_R0060772-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine > S-Adenosylhomocysteine + Ubiquinol-8 + Hydrogen ionPW_R0059482-Octaprenyl-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine > 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + S-Adenosylhomocysteine + Hydrogen ionPW_R005949a [phospholipid] olefinic fatty acid + S-adenosyl-L-methionine > a [phospholipid] cyclopropane fatty acid + S-Adenosylhomocysteine + Hydrogen ionPW_R006143S-Adenosylmethionine + Protein glutamate <> S-Adenosylhomocysteine + Protein glutamate methyl esterS-Adenosylmethionine + rRNA <> S-Adenosylhomocysteine + rRNA containing N2-methylguanineS-Adenosylmethionine <> S-Adenosylhomocysteine2 S-Adenosylmethionine + Reduced acceptor <> S-Adenosylhomocysteine +2 L-Methionine +5 5'-DeoxyadenosineS-Adenosylmethionine + DNA adenine <> S-Adenosylhomocysteine + DNA 6-methylaminopurine2 S-Adenosylmethionine + Uroporphyrinogen III >2 S-Adenosylhomocysteine + Precorrin 2 + Hydrogen ion2 2-Octaprenyl-6-hydroxyphenol + S-Adenosylmethionine >2 2-Octaprenyl-6-methoxyphenol + S-Adenosylhomocysteine + Hydrogen ionS-Adenosylmethionine + Protein L-isoaspartate <> S-Adenosylhomocysteine + Protein L-isoaspartate methyl esterS-Adenosylmethionine + rRNA <> S-Adenosylhomocysteine + rRNA containing N6-methyladenine2 S-Adenosylmethionine <> S-Adenosylhomocysteine +2 L-Methionine +5 5'-Deoxyadenosine2 2-Demethylmenaquinone 8 + S-Adenosylmethionine <> Menaquinone + S-Adenosylhomocysteine2 2-Phytyl-1,4-naphthoquinone + S-Adenosylmethionine <> Phylloquinone + S-AdenosylhomocysteineS-Adenosylmethionine + Protein glutamate <> S-Adenosylhomocysteine + Protein glutamate methyl ester2 S-Adenosylmethionine + Reduced acceptor <> S-Adenosylhomocysteine +2 L-Methionine +5 5'-DeoxyadenosineS-Adenosylmethionine + DNA adenine <> S-Adenosylhomocysteine + DNA 6-methylaminopurine2 S-Adenosylmethionine + Uroporphyrinogen III >2 S-Adenosylhomocysteine + Precorrin 2 + Hydrogen ionS-Adenosylmethionine + Protein L-isoaspartate <> S-Adenosylhomocysteine + Protein L-isoaspartate methyl esterS-Adenosylmethionine <> S-AdenosylhomocysteineS-Adenosylmethionine + rRNA <> S-Adenosylhomocysteine + rRNA containing N6-methyladenine