Record Information
Version2.0
Creation Date2012-05-31 09:56:09 -0600
Update Date2015-09-13 12:56:05 -0600
Secondary Accession Numbers
  • ECMDB00051
Identification
Name:Ammonia
Description:Ammonia is a colorless alkaline gas with a characteristic sharp smell. Ammonia is one of the most abundant nitrogen-containing compounds in the atmosphere. It is an irritant with a characteristic pungent odor, which is widely used in industry. Because of its many uses, ammonia is one of the most highly produced inorganic chemicals.
Structure
Thumb
Synonyms:
  • Am-fol
  • Ammonia
  • Ammonia (conc 20% or greater)
  • Ammonia anhydrous
  • Ammonia gas
  • Ammonia inhalant
  • Ammonia solution
  • Ammonia solution strong (NF)
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammonia water (JP15)
  • Ammoniac [french]
  • Ammoniaca [italian]
  • Ammoniacum gummi
  • Ammoniak
  • Ammoniak kconzentrierter
  • Ammoniak [german]
  • Ammoniakgas
  • Ammonium ion
  • Amoniak [polish]
  • Anhydrous ammonia
  • Aromatic ammonia vaporole
  • Azane
  • Liquid ammonia
  • NH(3)
  • NH3
  • NH3
  • NH{3)
  • Nitro-sil
  • Primaeres amin
  • Sekundaeres amin
  • Spirit of hartshorn
  • Tertiaeres amin
Chemical Formula:H3N
Weight:Average: 17.0305
Monoisotopic: 17.026549101
InChI Key:QGZKDVFQNNGYKY-UHFFFAOYSA-N
InChI:InChI=1S/H3N/h1H3
CAS number:7664-41-7
IUPAC Name:ammonia
Traditional IUPAC Name:ammonia
SMILES:N
Chemical Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'.
KingdomChemical entities
Super ClassInorganic compounds
ClassHomogeneous non-metal compounds
Sub ClassHomogeneous other non-metal compounds
Direct ParentHomogeneous other non-metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous other non metal
Molecular FrameworkNot Available
External Descriptors
Physical Properties
State:Liquid
Charge:1
Melting point:-77.7 °C
Experimental Properties:
PropertyValueSource
Water Solubility:482 mg/mL at 24 oC [DEAN,JA (1985)]PhysProp
Predicted Properties
PropertyValueSource
logP-0.98ChemAxon
pKa (Strongest Basic)8.86ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area13.59 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity15.51 m3·mol-1ChemAxon
Polarizability1.99 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Cytoplasm
Reactions:
4 Porphobilinogen + Water <> Hydroxymethylbilane +4 Ammonia
Adenosine triphosphate + Ammonia + Carbon dioxide <> ADP + Carbamoylphosphate
Adenosine triphosphate + Nicotinic acid adenine dinucleotide + Ammonia <> Adenosine monophosphate + Pyrophosphate + NAD
L-Serine <> Pyruvic acid + Ammonia
D-Serine <> Pyruvic acid + Ammonia
L-Glutamate + NAD + Water <> alpha-Ketoglutarate + Ammonia + NADH + Hydrogen ion
L-Glutamate + NADP + Water <> alpha-Ketoglutarate + Ammonia + NADPH + Hydrogen ion
Adenosine triphosphate + L-Glutamate + Ammonia <> ADP + Phosphate + L-Glutamine
L-Glutamine + Water <> L-Glutamate + Ammonia
Pyridoxamine 5'-phosphate + Water + Oxygen <> Pyridoxal 5'-phosphate + Ammonia + Hydrogen peroxide
L-Aspartic acid + Water + Oxygen <> Oxalacetic acid + Ammonia + Hydrogen peroxide
(S)-Ureidoglycolic acid + Water <> Glyoxylic acid +2 Ammonia + Carbon dioxide
Adenosine triphosphate + L-Aspartic acid + Ammonia <> Adenosine monophosphate + Pyrophosphate + L-Asparagine
L-Asparagine + Water <> L-Aspartic acid + Ammonia
L-Aspartic acid <> Fumaric acid + Ammonia
Cytidine triphosphate + Water <> Uridine triphosphate + Ammonia
Adenosine triphosphate + Uridine triphosphate + Ammonia <> ADP + Phosphate + Cytidine triphosphate
L-Tryptophan + Water <> Indole + Pyruvic acid + Ammonia
Ethanolamine <> Acetaldehyde + Ammonia
Glucosamine 6-phosphate + Water <> Fructose 6-phosphate + Ammonia
L-Cysteine + Water <> Hydrogen sulfide + Pyruvic acid + Ammonia
Ammonium hydroxide + 3 NAD + Water + Ammonia <> Nitrite +3 NADH +3 Hydrogen ion
Cytosine + Water <> Uracil + Ammonia
Chorismate + Ammonia <> 2-Aminobenzoic acid + Pyruvic acid + Water
L-Threonine <> 2-Ketobutyric acid + Ammonia
O-Succinyl-L-homoserine + Water <> 2-Ketobutyric acid + Succinic acid + Ammonia
Inosinic acid + Ammonia + NADP <> Guanosine monophosphate + NADPH + Hydrogen ion
Glycine + Tetrahydrofolic acid + NAD <> 5,10-Methylene-THF + Ammonia + Carbon dioxide + NADH + Hydrogen ion
Adenosine triphosphate + Xanthylic acid + Ammonia <> Adenosine monophosphate + Pyrophosphate + Guanosine monophosphate
Adenine + Water <> Hypoxanthine + Ammonia
Niacinamide + Water <> Nicotinic acid + Ammonia
Cystathionine + Water <> L-Homocysteine + Ammonia + Pyruvic acid
L-Cystathionine + Water <> L-Homocysteine + Ammonia + Pyruvic acid
alpha-Amino acid + Water + Acceptor <> 2-Oxo acid + Ammonia + Reduced acceptor
D-Phenylalanine + Water + Acceptor <> Phenylpyruvic acid + Ammonia + Reduced acceptor
5-Methylcytosine + Water <> Thymine + Ammonia
Adenosine + Water <> Inosine + Ammonia
D-Glutamine + Water <> D-Glutamic acid + Ammonia
Guanine + Water <> Xanthine + Ammonia
Pyridoxamine + Water + Oxygen <> Pyridoxal + Ammonia + Hydrogen peroxide
D-Cysteine + Water <> Hydrogen sulfide + Ammonia + Pyruvic acid
Cytidine + Water <> Uridine + Ammonia
dCTP + Water <> Deoxyuridine triphosphate + Ammonia
Tyramine + Water + Oxygen <> 4-Hydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide
L-Cystine + Water <> Pyruvic acid + Ammonia + Thiocysteine
Allantoic acid + Water <> Ureidoglycine + Ammonia + Carbon dioxide
Deoxycytidine + Water <> Deoxyuridine + Ammonia
Aminoacetone + Water + Oxygen <> Pyruvaldehyde + Ammonia + Hydrogen peroxide
Deoxyadenosine + Water <> Deoxyinosine + Ammonia
Phenylethylamine + Oxygen + Water <> Phenylacetaldehyde + Ammonia + Hydrogen peroxide
Creatinine + Water <> N-Methylhydantoin + Ammonia
1,3-Diaminopropane + Oxygen + Water <> 3-Aminopropionaldehyde + Ammonia + Hydrogen peroxide
2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + Water + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine <> 5-Amino-6-(5'-phosphoribosylamino)uracil + Ammonia
N-Methylputrescine + Oxygen + Hydrogen ion <> 1-Methylpyrrolinium + Hydrogen peroxide + Ammonia
S-Aminomethyldihydrolipoylprotein + Tetrahydrofolic acid + S-Aminomethyldihydrolipoylprotein <> Dihydrolipoylprotein + 5,10-Methylene-THF + Ammonia
N2-Succinyl-L-arginine + 2 Water <> N2-Succinyl-L-ornithine + Carbon dioxide +2 Ammonia
Dopamine + Water + Oxygen <> 3,4-Dihydroxyphenylacetaldehyde + Ammonia + Hydrogen peroxide
Selenocystathionine + Water <> Selenohomocysteine + Ammonia + Pyruvic acid
Adenosine triphosphate + Nitrogen + 6 Reduced flavodoxin + Water <> Phosphate + ADP +6 Oxidized flavodoxin +2 Ammonia
Ureidoglycine + Water <> (S)-Ureidoglycolic acid + Ammonia
Ammonia + 2 Water + 6 Ferricytochrome c + Ferricytochrome c <> Nitrite +6 Ferrocytochrome c +6 Hydrogen ion + Ferrocytochrome c
Methylamine + Oxygen + Water <> Formaldehyde + Ammonia + Hydrogen peroxide
Cadaverine + Water + Oxygen <> 5-Aminopentanal + Ammonia + Hydrogen peroxide
gamma-Glutamyl-L-putrescine + Water + Oxygen <> gamma-Glutamyl-gamma-butyraldehyde + Ammonia + Hydrogen peroxide
Aniline + Oxygen <> Pyrocatechol + Ammonia
5'-Deoxy-5-fluorocytidine + Water <> 5'-Deoxy-5-fluorouridine + Ammonia
D-Galactosamine 6-phosphate + Water <> D-Tagatose 6-phosphate + Ammonia
Se-Methylselenocysteine + Water <> Pyruvic acid + Ammonia + Methaneselenol
3-Aminoacrylate + Water <> Malonic semialdehyde + Ammonia
6-Carboxy-5,6,7,8-tetrahydropterin <> 7-Carboxy-7-carbaguanine + Ammonia + 7-Deaza-7-carboxyguanine
Water + Deoxyadenosine > Ammonia + Deoxyinosine
NAD + Glycine + Tetrahydrofolic acid > Hydrogen ion + 5,10-Methylene-THF + Ammonia + Carbon dioxide + NADH
Ammonia + Water <> Ammonium + OH<SUP>-</SUP>
Dehydroglycine + Water > Glyoxylic acid + Ammonia
Ammonia + Hydrogen ion <> Ammonium
Carbamic acid + Hydrogen ion > Ammonia + Carbon dioxide
3-Aminoacrylate + Water > Malonic semialdehyde + Ammonia
isoguanine + Water > Xanthine + Ammonia
2,3-diaminopropanoate + Water > Hydrogen ion + Ammonia + Pyruvic acid
L-Serine > Hydrogen ion + Pyruvic acid + Ammonia
Water + Adenine > Ammonia + Hypoxanthine
Water + Adenosine > Ammonia + Inosine
Hydrogen ion + Allantoic acid + Water > <i>S</i>-ureidoglycine + Ammonia + Carbon dioxide
Aminoacetone + Water + Oxygen > Hydrogen ion + Pyruvaldehyde + Ammonia + Hydrogen peroxide
an aliphatic amine + Water + Oxygen > an aldehyde + Ammonia + Hydrogen peroxide + Hydrogen ion
Water + Oxygen + Phenylethylamine > Hydrogen ion + Hydrogen peroxide + Ammonia + Phenylacetaldehyde
Ammonia + L-Aspartic acid + Adenosine triphosphate > L-Asparagine + Pyrophosphate + Adenosine monophosphate
L-Asparagine + Water > Hydrogen ion + L-Aspartic acid + Ammonia
L-Aspartic acid <> Hydrogen ion + Fumaric acid + Ammonia
Ammonia + Carbon dioxide + Adenosine triphosphate < Hydrogen ion + Carbamoylphosphate + ADP
L-Cystathionine + Water > Hydrogen ion + Pyruvic acid + Ammonia + L-Homocysteine
Water + Cytosine > Ammonia + Uracil
Water + Deoxycytidine > Ammonia + Deoxyuridine
Water + Cytidine > Ammonia + Uridine
Water + dCTP > Ammonia + Deoxyuridine triphosphate
D-Cysteine + Water <> Pyruvic acid + Hydrogen sulfide + Ammonia + Hydrogen ion
D-Serine > Hydrogen ion + Pyruvic acid + Ammonia
Ethanolamine > Hydrogen ion + Acetaldehyde + Ammonia
Glucosamine 6-phosphate + Water <> Hydrogen ion + Fructose 6-phosphate + Ammonia
L-Glutamine + Water > Hydrogen ion + L-Glutamate + Ammonia
Ammonia + L-Glutamate + Adenosine triphosphate > L-Glutamine + ADP + Phosphate
L-Glutamate + Water + NADP <> Hydrogen ion + Oxoglutaric acid + Ammonia + NADPH
Ammonia + Inosinic acid + NADP < Hydrogen ion + Guanosine monophosphate + NADPH
Adenosine triphosphate + Xanthylic acid + Ammonia > Hydrogen ion + Adenosine monophosphate + Pyrophosphate + Guanosine monophosphate
Water + Guanine > Ammonia + Xanthine
Ammonia + Water + an oxidized electron acceptor < a reduced electron acceptor + hydroxylamine
L-Cysteine + Water > Pyruvic acid + Ammonia + Hydrogen sulfide + Hydrogen ion
Hydrogen ion + 2-Ketobutyric acid + Succinic acid + Ammonia O-Succinyl-L-homoserine + Water
Adenosine triphosphate + Nicotinic acid adenine dinucleotide + Ammonia > Adenosine monophosphate + Pyrophosphate + NAD
Niacinamide + Water > Hydrogen ion + Nicotinic acid + Ammonia
Nicotinamide ribotide + Water > Hydrogen ion + Nicotinamide ribotide + Ammonia
Water + Porphobilinogen <> Hydrogen ion + Ammonia + Hydroxymethylbilane
Oxygen + Water + Pyridoxamine 5'-phosphate > Hydrogen ion + Hydrogen peroxide + Ammonia + Pyridoxal 5'-phosphate
+ Water Hydrogen ion + Pyrazinic acid + Ammonia
Water + 2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine > 5-Amino-6-(5'-phosphoribosylamino)uracil + Ammonia
7-carboxy-7-deazaguanine + Ammonia + Adenosine triphosphate > 7-Cyano-7-carbaguanine + ADP + Phosphate + Water
Adenosine triphosphate + Hydrogen carbonate + Ammonia > ADP + Phosphate + Carbamoylphosphate + Hydrogen ion
a primary amine + Water + Oxygen > an aldehyde + Ammonia + Hydrogen peroxide
6-Carboxy-5,6,7,8-tetrahydropterin + S-Adenosylmethionine + Hydrogen ion > 7-carboxy-7-deazaguanine + 5'-Deoxyadenosine + L-Methionine + Ammonia
N2-Succinyl-L-arginine + Water > N2-Succinyl-L-ornithine + Ammonia + Carbon dioxide
L-Threonine > Hydrogen ion + 2-Ketobutyric acid + Ammonia
L-Tryptophan + Water <> Hydrogen ion + Indole + Pyruvic acid + Ammonia
<i>S</i>-ureidoglycine + Water > Hydrogen ion + Ammonia + (S)-Ureidoglycolic acid
Adenosine + Water > Inosine + Ammonia
Adenine + Water > Hypoxanthine + Ammonia
D-Galactosamine 6-phosphate + Water > D-Tagatose 6-phosphate + Ammonia
(S)-Ureidoglycolic acid + Water > Glyoxylic acid +2 Ammonia + Carbon dioxide
RCH(2)NH(2) + Water + Oxygen > RCHO + Ammonia + Hydrogen peroxide
Phenylethylamine + Water + Oxygen > Phenylacetaldehyde + Ammonia + Hydrogen peroxide
Adenosine triphosphate + Ammonia + Carbon dioxide > ADP + Carbamoylphosphate
Adenosine triphosphate + L-Aspartic acid + Ammonia > Adenosine monophosphate + Pyrophosphate + L-Asparagine
L-Aspartic acid > Fumaric acid + Ammonia
L-Asparagine + Water > L-Aspartic acid + Ammonia
L-Asparagine + Water > L-Aspartic acid + Ammonia
N2-Succinyl-L-arginine + 2 Water > N2-Succinyl-L-ornithine +2 Ammonia + Carbon dioxide
Cytidine + Water > Uridine + Ammonia
Cytosine + Water > Uracil + Ammonia
Cyanate + Carbonic acid + 2 Hydrogen ion > Ammonia +2 Carbon dioxide
A D-amino acid + Water + acceptor > a 2-oxo acid + Ammonia + reduced acceptor
dCTP + Water > Deoxyuridine triphosphate + Ammonia
D-Cysteine + Water > Hydrogen sulfide + Ammonia + Pyruvic acid
L-Glutamate + Water + NADP > Oxoglutaric acid + Ammonia + NADPH
2,3-diaminopropionate + Water > Pyruvic acid +2 Ammonia
Ethanolamine > Acetaldehyde + Ammonia
Ethanolamine > Acetaldehyde + Ammonia
[Protein]-S(8)-aminomethyldihydrolipoyllysine + Tetrahydrofolic acid > [protein]-dihydrolipoyllysine + 5,10-Methylene-THF + Ammonia
Adenosine triphosphate + L-Glutamate + Ammonia > ADP + Inorganic phosphate + L-Glutamine
L-Glutamine + Water > L-Glutamate + Ammonia
L-Glutamine + Water > L-Glutamate + Ammonia
Inosinic acid + Ammonia + NADP > Guanosine monophosphate + NADPH
Guanine + Water > Xanthine + Ammonia
4 Porphobilinogen + Water > Hydroxymethylbilane +4 Ammonia
L-Threonine > 2-Ketobutyric acid + Ammonia
L-Cystathionine + Water > L-Homocysteine + Ammonia + Pyruvic acid
L-Cystathionine + Water > L-Homocysteine + Ammonia + Pyruvic acid
Adenosine triphosphate + Nicotinic acid adenine dinucleotide + Ammonia > Adenosine monophosphate + Pyrophosphate + NAD
D-glucosamine 6-phosphate + Water > Fructose 6-phosphate + Ammonia
Ammonia + 2 Water + 6 Ferricytochrome c > Nitrite +6 Ferrocytochrome c +7 Hydrogen ion
Pyridoxamine 5'-phosphate + Water + Oxygen > Pyridoxal 5'-phosphate + Ammonia + Hydrogen peroxide
Niacinamide + Water > Nicotinic acid + Ammonia
gamma-Glutamyl-L-putrescine + Water + Oxygen > Gamma-glutamyl-gamma-aminobutyraldehyde + Ammonia + Hydrogen peroxide
Adenosine triphosphate + Uridine triphosphate + Ammonia > ADP + Inorganic phosphate + Cytidine triphosphate
7-Deaza-7-carboxyguanine + Ammonia + Adenosine triphosphate > 7-Cyano-7-carbaguanine + ADP + Inorganic phosphate + Water
6-Carboxy-5,6,7,8-tetrahydropterin > 7-Deaza-7-carboxyguanine + Ammonia
2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + Water > 5-Amino-6-(5'-phosphoribosylamino)uracil + Ammonia
Iminobutyrate + Water > 2-Ketobutyric acid + Ammonia
Ureidoacrylate peracid + Water > Peroxyaminoacrylate + Ammonia
(Z)-3-Ureidoacrylate + Water > 3-Aminoacrylate + Carbon dioxide + Ammonia
(Z)-2-Methyl-ureidoacrylate peracid + Water > (Z)-2-Methyl-peroxyaminoacrylate + Carbon dioxide + Ammonia
3-Aminoacrylate + Water > Malonic acid + Ammonia
D-Serine > Pyruvic acid + Ammonia
L-Serine > Pyruvic acid + Ammonia
L-Serine > Pyruvic acid + Ammonia
Adenosine + Water > Inosine + Ammonia
L-Threonine > 2-Ketobutyric acid + Ammonia
L-Serine > Pyruvic acid + Ammonia
L-Serine > Pyruvic acid + Ammonia
L-Tryptophan + Water > Indole + Pyruvic acid + Ammonia
L-Threonine + 2-Aminobut-2-enoate + 2-Iminobutanoate + Water <> 2-Ketobutyric acid + Ammonia
Adenosine triphosphate + Uridine triphosphate + L-Glutamine + Water + Ammonia <> ADP + Phosphate + Cytidine triphosphate + L-Glutamate
2 Adenosine triphosphate + L-Glutamine + Hydrogen carbonate + Water + Ammonia + Carbamic acid + Carboxyphosphate <>2 ADP + Phosphate + L-Glutamate + Carbamoylphosphate
Cyanate + Hydrogen carbonate + 2 Hydrogen ion + Carbamic acid <> Ammonia +2 Carbon dioxide
D-Amino acid + Water + Acceptor <> 2-Oxo acid + Ammonia + Reduced acceptor
L-Cystathionine + Water + 2-Aminoacrylic acid + 2-Iminopropanoate <> L-Homocysteine + Pyruvic acid + Ammonia
L-Serine + 2-Aminoacrylic acid + 2-Iminopropanoate + Water <> Pyruvic acid + Ammonia
Cytidine + Water + Deoxycytidine <> Uridine + Ammonia + Deoxyuridine
D-Serine + 2-Aminoacrylic acid + 2-Iminopropanoate + Water <> Pyruvic acid + Ammonia
2,3-Diaminopropanoate + Water <> Pyruvic acid +2 Ammonia
2 L-Glutamate + NADP + Ammonia + Water <> L-Glutamine + alpha-Ketoglutarate + NADPH + Hydrogen ion
L-Tryptophan + Water + 2-Aminoacrylic acid + 2-Iminopropanoate <> Indole + Pyruvic acid + Ammonia
7-Deaza-7-carboxyguanine + Ammonia + Adenosine triphosphate <> 7-Cyano-7-carbaguanine + ADP + Phosphate + Water
Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water + Ammonia <> Adenosine monophosphate + Pyrophosphate + L-Asparagine + L-Glutamate
Ammonia + Water + Acceptor <> Hydroxylamine + Reduced acceptor
Ureidoacrylate peracid + Water + Carbamic acid + (Z)-2-Methyl-ureidoacrylate peracid <> Peroxyaminoacrylate + Carbon dioxide + Ammonia + (Z)-2-Methyl-peroxyaminoacrylate
Primary amine + Water + Oxygen <> Aldehyde + Ammonia + Hydrogen peroxide
Pyridoxamine 5'-phosphate + Water + Oxygen + Pyridoxine 5'-phosphate <> Pyridoxal 5'-phosphate + Ammonia + Hydrogen peroxide
Adenosine triphosphate + Xanthylic acid + L-Glutamine + Water + Ammonia <> Adenosine monophosphate + Pyrophosphate + Guanosine monophosphate + L-Glutamate
Water <> Ammonia
NMN + Water <> Nicotinamide ribotide + Ammonia
Ammonia + NAD + 3 NADP + 2 Water <> Nitrite + NADH +3 NADPH +5 Hydrogen ion
Nitrite + 3 NADH + 5 Hydrogen ion + Nitrite Ammonia +2 Water +3 NAD
Nitrite + 6 ferrocytochrome c + 7 Hydrogen ion + Nitrite + 6 Ferrocytochrome c <> Ammonia +6 ferricytochrome c +2 Water +6 Ferricytochrome c
Hydroxylamine + cytochrome c nitrite reductase <> Ammonia + Water + cytochrome c nitrite reductase
Ammonia + L-Glutamic acid + Adenosine triphosphate + Oxoglutaric acid + L-Glutamate <> Phosphate + L-Glutamine + Adenosine diphosphate + ADP
Hydrogen ion + NADPH + Ammonia + NADPH <> Water + NADP + L-Glutamic acid + L-Glutamate
L-Glutamine + Water > L-Glutamic acid + Ammonia + L-Glutamate
D-Glutamine + Water > D-Glutamic acid + Ammonia
S-Aminomethyldihydrolipoylprotein; + Tetrahydrofolic acid + Tetrahydrofolic acid <> 5,10-Methylene-THF + Ammonia + dihydrolipoylprotein + 5,10-Methylene-THF
Adenosine triphosphate + L-Aspartic acid + Ammonia + L-Aspartic acid > Adenosine monophosphate + L-Asparagine + Pyrophosphate + L-Asparagine
L-Aspartic acid + Water + Oxygen + L-Aspartic acid > Oxalacetic acid + Ammonia + Hydrogen peroxide
L-Aspartic acid + L-Aspartic acid > Fumaric acid + Ammonia
Phenylpyruvic acid + Ammonia + cytochrome c nitrite reductase <> D-Phenylalanine + Water + cytochrome c nitrite reductase
Adenosine triphosphate + Nitrogen + 6 a reduced flavodoxin + Water <> Phosphate + Adenosine diphosphate + an oxidized flavodoxin +2 Ammonia + ADP
More...

SMPDB Pathways:
Aspartate metabolismPW000787 Pw000787Pw000787 greyscalePw000787 simple
D-Glutamine and D-glutamate metabolismPW000769 Pw000769Pw000769 greyscalePw000769 simple
Folate biosynthesisPW000908 Pw000908Pw000908 greyscalePw000908 simple
L-glutamate metabolismPW000789 Pw000789Pw000789 greyscalePw000789 simple
L-glutamate metabolism IIPW001886 Pw001886Pw001886 greyscalePw001886 simple
Nitrogen metabolismPW000755 Pw000755Pw000755 greyscalePw000755 simple
One Carbon Pool by Folate IPW001735 Pw001735Pw001735 greyscalePw001735 simple
One carbon pool by folatePW000773 Pw000773Pw000773 greyscalePw000773 simple
Phenylalanine metabolismPW000921 Pw000921Pw000921 greyscalePw000921 simple
Pyrimidine metabolismPW000942 Pw000942Pw000942 greyscalePw000942 simple
Sulfur metabolismPW000922 Pw000922Pw000922 greyscalePw000922 simple
Tryptophan metabolismPW000815 Pw000815Pw000815 greyscalePw000815 simple
beta-Alanine metabolismPW000896 Pw000896Pw000896 greyscalePw000896 simple
KEGG Pathways:
EcoCyc Pathways:
Concentrations
Not Available
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-MSNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014i-9000000000-88ae09421d46f7dea1c5View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-014i-9000000000-88ae09421d46f7dea1c5View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-014i-9000000000-88ae09421d46f7dea1c5View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-014i-9000000000-5e750288766bc8c562ffView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-014i-9000000000-5e750288766bc8c562ffView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-014i-9000000000-5e750288766bc8c562ffView in MoNA
MSMass Spectrum (Electron Ionization)splash10-014i-9000000000-e0a6e51ead158714099bView in MoNA
References
References:
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  • Brautbar N, Wu MP, Richter ED: Chronic ammonia inhalation and interstitial pulmonary fibrosis: a case report and review of the literature. Arch Environ Health. 2003 Sep;58(9):592-6. Pubmed: 15369278
  • Cohen BI: The significance of ammonia/gamma-aminobutyric acid (GABA) ratio for normality and liver disorders. Med Hypotheses. 2002 Dec;59(6):757-8. Pubmed: 12445521
  • Cooper AJ: Role of glutamine in cerebral nitrogen metabolism and ammonia neurotoxicity. Ment Retard Dev Disabil Res Rev. 2001;7(4):280-6. Pubmed: 11754523
  • Geier M, Bosch OJ, Boeckh J: Ammonia as an attractive component of host odour for the yellow fever mosquito, Aedes aegypti. Chem Senses. 1999 Dec;24(6):647-53. Pubmed: 10587497
  • Grasten SM, Juntunen KS, Poutanen KS, Gylling HK, Miettinen TA, Mykkanen HM: Rye bread improves bowel function and decreases the concentrations of some compounds that are putative colon cancer risk markers in middle-aged women and men. J Nutr. 2000 Sep;130(9):2215-21. Pubmed: 10958815
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  • Hussein HS, Flickinger EA, Fahey GC Jr: Petfood applications of inulin and oligofructose. J Nutr. 1999 Jul;129(7 Suppl):1454S-6S. Pubmed: 10395620
  • Iwata H, Ueda Y: Pharmacokinetic considerations in development of a bioartificial liver. Clin Pharmacokinet. 2004;43(4):211-25. Pubmed: 15005636
  • Kaiho T, Tanaka T, Tsuchiya S, Yanagisawa S, Takeuchi O, Miura M, Saigusa N, Miyazaki M: Effect of the herbal medicine Dai-kenchu-to for serum ammonia in hepatectomized patients. Hepatogastroenterology. 2005 Jan-Feb;52(61):161-5. Pubmed: 15783019
  • Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. Pubmed: 22080510
  • Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. Pubmed: 21097882
  • Kochar DK, Agarwal P, Kochar SK, Jain R, Rawat N, Pokharna RK, Kachhawa S, Srivastava T: Hepatocyte dysfunction and hepatic encephalopathy in Plasmodium falciparum malaria. QJM. 2003 Jul;96(7):505-12. Pubmed: 12881593
  • Norenberg MD, Rama Rao KV, Jayakumar AR: Ammonia neurotoxicity and the mitochondrial permeability transition. J Bioenerg Biomembr. 2004 Aug;36(4):303-7. Pubmed: 15377862
  • Nybo L, Dalsgaard MK, Steensberg A, Moller K, Secher NH: Cerebral ammonia uptake and accumulation during prolonged exercise in humans. J Physiol. 2005 Feb 15;563(Pt 1):285-90. Epub 2004 Dec 20. Pubmed: 15611036
  • Ohmoto K, Miyake I, Tsuduki M, Ohno S, Yamamoto S: Control of solitary gastric fundal varices and portosystemic encephalopathy accompanying liver cirrhosis by balloon-occluded retrograde transvenous obliteration (B-RTO): a case report. Hepatogastroenterology. 1999 Mar-Apr;46(26):1249-52. Pubmed: 10370701
  • Pita AM, Wakabayashi Y, Fernandez-Bustos MA, Virgili N, Riudor E, Soler J, Farriol M: Plasma urea-cycle-related amino acids, ammonium levels, and urinary orotic acid excretion in short-bowel patients managed with an oral diet. Clin Nutr. 2003 Feb;22(1):93-8. Pubmed: 12553956
  • Remer T: Influence of nutrition on acid-base balance--metabolic aspects. Eur J Nutr. 2001 Oct;40(5):214-20. Pubmed: 11842946
  • Satoh M, Yokoya S, Hachiya Y, Hachiya M, Fujisawa T, Hoshino K, Saji T: Two hyperandrogenic adolescent girls with congenital portosystemic shunt. Eur J Pediatr. 2001 May;160(5):307-11. Pubmed: 11388600
  • Seiler N: Ammonia and Alzheimer's disease. Neurochem Int. 2002 Aug-Sep;41(2-3):189-207. Pubmed: 12020619
  • Shawcross DL, Damink SW, Butterworth RF, Jalan R: Ammonia and hepatic encephalopathy: the more things change, the more they remain the same. Metab Brain Dis. 2005 Sep;20(3):169-79. Pubmed: 16167195
  • Suarez I, Bodega G, Fernandez B: Glutamine synthetase in brain: effect of ammonia. Neurochem Int. 2002 Aug-Sep;41(2-3):123-42. Pubmed: 12020613
  • Verrotti A, Greco R, Morgese G, Chiarelli F: Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs. Int J Clin Lab Res. 1999;29(1):36-40. Pubmed: 10356662
  • Yoshida Y, Higashi T, Nouso K, Nakatsukasa H, Nakamura SI, Watanabe A, Tsuji T: Effects of zinc deficiency/zinc supplementation on ammonia metabolism in patients with decompensated liver cirrhosis. Acta Med Okayama. 2001 Dec;55(6):349-55. Pubmed: 11779097
  • Zupke C, Sinskey AJ, Stephanopoulos G: Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36. Pubmed: 8579834
Synthesis Reference:Mohr, Rudolf. Ammonia separation from offgas obtained from melamine synthesis. U.S. (1971), 5 pp. CODEN: USXXAM US 3555784 19710119 CAN 77:50902 AN 1972:450902
Material Safety Data Sheet (MSDS)Download (PDF)
External Links:
ResourceLink
CHEBI ID16134
HMDB IDHMDB00051
Pubchem Compound ID222
Kegg IDC00014
ChemSpider ID217
WikipediaAmmonia
BioCyc IDAMMONIA
EcoCyc IDAMMONIA
Ligand ExpoNH4

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH
Gene Name:
gdhA
Uniprot ID:
P00370
Molecular weight:
48581
Reactions
L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH.
General function:
Involved in asparaginase activity
Specific function:
L-asparagine + H(2)O = L-aspartate + NH(3)
Gene Name:
ansB
Uniprot ID:
P00805
Molecular weight:
36851
Reactions
L-asparagine + H(2)O = L-aspartate + NH(3).
General function:
Involved in cyanate hydratase activity
Specific function:
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
Gene Name:
cynS
Uniprot ID:
P00816
Molecular weight:
17049
Reactions
Cyanate + HCO(3)(-) + 2 H(+) = NH(3) + 2 CO(2).
General function:
Involved in biosynthetic process
Specific function:
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
Gene Name:
trpE
Uniprot ID:
P00895
Molecular weight:
57494
Reactions
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
General function:
Involved in anthranilate phosphoribosyltransferase activity
Specific function:
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
Gene Name:
trpD
Uniprot ID:
P00904
Molecular weight:
56869
Reactions
Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in D-serine ammonia-lyase activity
Specific function:
D-serine = pyruvate + NH(3)
Gene Name:
dsdA
Uniprot ID:
P00926
Molecular weight:
47900
Reactions
D-serine = pyruvate + NH(3).
General function:
Involved in pyridoxal phosphate binding
Specific function:
O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate
Gene Name:
metB
Uniprot ID:
P00935
Molecular weight:
41550
Reactions
O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate.
General function:
Involved in nucleotide binding
Specific function:
ATP + L-aspartate + NH(3) = AMP + diphosphate + L-asparagine
Gene Name:
asnA
Uniprot ID:
P00963
Molecular weight:
36650
Reactions
ATP + L-aspartate + NH(3) = AMP + diphosphate + L-asparagine.
General function:
Involved in GMP synthase (glutamine-hydrolyzing) activity
Specific function:
Catalyzes the synthesis of GMP from XMP
Gene Name:
guaA
Uniprot ID:
P04079
Molecular weight:
58679
Reactions
ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent
Gene Name:
ilvA
Uniprot ID:
P04968
Molecular weight:
56195
Reactions
L-threonine = 2-oxobutanoate + NH(3).
General function:
Involved in pyridoxal phosphate binding
Specific function:
L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate
Gene Name:
metC
Uniprot ID:
P06721
Molecular weight:
43212
Reactions
L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate.
General function:
Involved in hydroxymethylbilane synthase activity
Specific function:
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
Gene Name:
hemC
Uniprot ID:
P06983
Molecular weight:
33851
Reactions
4 porphobilinogen + H(2)O = hydroxymethylbilane + 4 NH(3).
General function:
Involved in oxidation-reduction process
Specific function:
Ammonium hydroxide + 3 NAD(P)(+) + H(2)O = nitrite + 3 NAD(P)H
Gene Name:
nirB
Uniprot ID:
P08201
Molecular weight:
93121
Reactions
Ammonium hydroxide + 3 NAD(P)(+) + H(2)O = nitrite + 3 NAD(P)H.
General function:
Involved in catalytic activity
Specific function:
2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH
Gene Name:
gltB
Uniprot ID:
P09831
Molecular weight:
166708
Reactions
2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH.
General function:
Involved in iron-sulfur cluster binding
Specific function:
2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH
Gene Name:
gltD
Uniprot ID:
P09832
Molecular weight:
52015
Reactions
2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH.
General function:
Involved in D-amino-acid dehydrogenase activity
Specific function:
Oxidative deamination of D-amino acids
Gene Name:
dadA
Uniprot ID:
P0A6J5
Molecular weight:
47607
Reactions
A D-amino acid + H(2)O + acceptor = a 2-oxo acid + NH(3) + reduced acceptor.
General function:
Involved in glutaminase activity
Specific function:
L-glutamine + H(2)O = L-glutamate + NH(3)
Gene Name:
glsA2
Uniprot ID:
P0A6W0
Molecular weight:
33515
Reactions
L-glutamine + H(2)O = L-glutamate + NH(3).
General function:
Involved in carbohydrate metabolic process
Specific function:
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion
Gene Name:
nagB
Uniprot ID:
P0A759
Molecular weight:
29774
Reactions
D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3).
General function:
Involved in CTP synthase activity
Specific function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen
Gene Name:
pyrG
Uniprot ID:
P0A7E5
Molecular weight:
60374
Reactions
ATP + UTP + NH(3) = ADP + phosphate + CTP.
General function:
Involved in lyase activity
Specific function:
L-tryptophan + H(2)O = indole + pyruvate + NH(3)
Gene Name:
tnaA
Uniprot ID:
P0A853
Molecular weight:
52773
Reactions
L-tryptophan + H(2)O = indole + pyruvate + NH(3).
General function:
Involved in asparaginase activity
Specific function:
L-asparagine + H(2)O = L-aspartate + NH(3)
Gene Name:
ansA
Uniprot ID:
P0A962
Molecular weight:
37127
Reactions
L-asparagine + H(2)O = L-aspartate + NH(3).
General function:
Involved in glutamate-ammonia ligase activity
Specific function:
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine
Gene Name:
glnA
Uniprot ID:
P0A9C5
Molecular weight:
51903
Reactions
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.
General function:
Involved in nitrite reductase [NAD(P)H] activity
Specific function:
Required for activity of the reductase
Gene Name:
nirD
Uniprot ID:
P0A9I8
Molecular weight:
12284
Reactions
Ammonium hydroxide + 3 NAD(P)(+) + H(2)O = nitrite + 3 NAD(P)H.
General function:
Involved in oxidoreductase activity
Specific function:
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes
Gene Name:
lpdA
Uniprot ID:
P0A9P0
Molecular weight:
50688
Reactions
Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
General function:
Involved in zinc ion binding
Specific function:
This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
Gene Name:
cdd
Uniprot ID:
P0ABF6
Molecular weight:
31539
Reactions
Cytidine + H(2)O = uridine + NH(3).
General function:
Involved in nitrogen compound metabolic process
Specific function:
Plays a role in nitrite reduction
Gene Name:
nrfA
Uniprot ID:
P0ABK9
Molecular weight:
53703
Reactions
NH(3) + 2 H(2)O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H(+).
General function:
Involved in aspartate ammonia-lyase activity
Specific function:
L-aspartate = fumarate + NH(3)
Gene Name:
aspA
Uniprot ID:
P0AC38
Molecular weight:
52356
Reactions
L-aspartate = fumarate + NH(3).
General function:
Involved in catalytic activity
Specific function:
Ethanolamine = acetaldehyde + NH(3)
Gene Name:
eutB
Uniprot ID:
P0AEJ6
Molecular weight:
49403
Reactions
Ethanolamine = acetaldehyde + NH(3).
General function:
Involved in catalytic activity
Specific function:
Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase
Gene Name:
tdcB
Uniprot ID:
P0AGF6
Molecular weight:
35232
Reactions
L-threonine = 2-oxobutanoate + NH(3).
L-serine = pyruvate + NH(3).
General function:
Involved in electron carrier activity
Specific function:
Catalyzes the oxidation of L-aspartate to iminoaspartate
Gene Name:
nadB
Uniprot ID:
P10902
Molecular weight:
60337
Reactions
L-aspartate + O(2) = iminosuccinate + H(2)O(2).
General function:
Involved in L-serine ammonia-lyase activity
Specific function:
Deaminates also threonine, particularly when it is present in high concentration
Gene Name:
sdaA
Uniprot ID:
P16095
Molecular weight:
48906
Reactions
L-serine = pyruvate + NH(3).
General function:
Involved in NAD+ synthase (glutamine-hydrolyzing) activity
Specific function:
Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction
Gene Name:
nadE
Uniprot ID:
P18843
Molecular weight:
30637
Reactions
ATP + deamido-NAD(+) + NH(3) = AMP + diphosphate + NAD(+).
General function:
Involved in ethanolamine ammonia-lyase activity
Specific function:
Ethanolamine = acetaldehyde + NH(3)
Gene Name:
eutC
Uniprot ID:
P19636
Molecular weight:
31781
Reactions
Ethanolamine = acetaldehyde + NH(3).
General function:
Involved in catalytic activity
Specific function:
Nicotinamide + H(2)O = nicotinate + NH(3)
Gene Name:
pncA
Uniprot ID:
P21369
Molecular weight:
23362
Reactions
Nicotinamide + H(2)O = nicotinate + NH(3).
General function:
Involved in deaminase activity
Specific function:
Adenosine + H(2)O = inosine + NH(3)
Gene Name:
add
Uniprot ID:
P22333
Molecular weight:
36397
Reactions
Adenosine + H(2)O = inosine + NH(3).
General function:
Involved in transferase activity
Specific function:
Acts as a beta-cystathionase and as a repressor of the maltose regulon
Gene Name:
malY
Uniprot ID:
P23256
Molecular weight:
43641
Reactions
L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate.
General function:
Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Specific function:
Cytosine + H(2)O = uracil + NH(3)
Gene Name:
codA
Uniprot ID:
P25524
Molecular weight:
47591
Reactions
Cytosine + H(2)O = uracil + NH(3).
General function:
Involved in zinc ion binding
Specific function:
Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Gene Name:
ribD
Uniprot ID:
P25539
Molecular weight:
40338
Reactions
2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5-phosphoribosylamino)uracil + NH(3).
5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH.
General function:
Involved in aminomethyltransferase activity
Specific function:
The glycine cleavage system catalyzes the degradation of glycine
Gene Name:
gcvT
Uniprot ID:
P27248
Molecular weight:
40146
Reactions
[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3).
General function:
Involved in dCTP deaminase activity
Specific function:
dCTP + H(2)O = dUTP + NH(3)
Gene Name:
dcd
Uniprot ID:
P28248
Molecular weight:
21249
Reactions
dCTP + H(2)O = dUTP + NH(3).
General function:
Involved in L-serine ammonia-lyase activity
Specific function:
Deaminates also threonine, particularly when it is present in high concentration
Gene Name:
sdaB
Uniprot ID:
P30744
Molecular weight:
48753
Reactions
L-serine = pyruvate + NH(3).
General function:
Involved in adenine deaminase activity
Specific function:
Adenine + H(2)O = hypoxanthine + NH(3)
Gene Name:
ade
Uniprot ID:
P31441
Molecular weight:
63739
Reactions
Adenine + H(2)O = hypoxanthine + NH(3).
General function:
Involved in glycine dehydrogenase (decarboxylating) activity
Specific function:
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein
Gene Name:
gcvP
Uniprot ID:
P33195
Molecular weight:
104376
Reactions
Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO(2).
General function:
Involved in cellular amino acid biosynthetic process
Specific function:
ATP + NH(3) + CO(2) = ADP + carbamoyl phosphate
Gene Name:
arcC
Uniprot ID:
P37306
Molecular weight:
31644
Reactions
ATP + NH(3) + CO(2) = ADP + carbamoyl phosphate.
General function:
Involved in oxidoreductase activity
Specific function:
Involved in the breakdown of putrescine via the oxidation of L-glutamylputrescine
Gene Name:
puuB
Uniprot ID:
P37906
Molecular weight:
47169
Reactions
Gamma-glutamylputrescine + H(2)O + O(2) = Gamma-glutamyl-gamma-aminobutyraldehyde + NH(3) + H(2)O(2).
General function:
Involved in L-serine ammonia-lyase activity
Specific function:
L-serine = pyruvate + NH(3)
Gene Name:
tdcG
Uniprot ID:
P42630
Molecular weight:
48521
Reactions
L-serine = pyruvate + NH(3).
General function:
Involved in carbohydrate metabolic process
Specific function:
D-galactosamine 6-phosphate + H(2)O = D- tagatose 6-phosphate + NH(3)
Gene Name:
agaI
Uniprot ID:
P42912
Molecular weight:
27724
Reactions
D-galactosamine 6-phosphate + H(2)O = D-tagatose 6-phosphate + NH(3).
General function:
Involved in copper ion binding
Specific function:
The enzyme prefers aromatic over aliphatic amines
Gene Name:
tynA
Uniprot ID:
P46883
Molecular weight:
84378
Reactions
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
2-phenylethylamine + H(2)O + O(2) = phenylacetaldehyde + NH(3) + H(2)O(2).
General function:
Involved in catalytic activity
Specific function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides
Gene Name:
guaC
Uniprot ID:
P60560
Molecular weight:
37383
Reactions
Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH.
General function:
Involved in diaminopropionate ammonia-lyase activity
Specific function:
Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate, the most suitable substrates to form pyruvate and ammonia. The L- and D-isomers of serine are also degraded, though slowly; it is the only serine dehydratase which can eliminate an amino group at the beta-carbon position
Gene Name:
ygeX
Uniprot ID:
P66899
Molecular weight:
43327
Reactions
2,3-diaminopropionate + H(2)O = pyruvate + 2 NH(3).
General function:
Involved in oxidoreductase activity, acting on other nitrogenous compounds as donors
Specific function:
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. Is also able to reduce hydroxylamine analogs such as methylhydroxylamine and hydroxyquinone. Might have a role as a scavenger of potentially toxic by-products of nitrate metabolism
Gene Name:
hcp
Uniprot ID:
P75825
Molecular weight:
60063
General function:
Involved in N-succinylarginine dihydrolase activity
Specific function:
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2)
Gene Name:
astB
Uniprot ID:
P76216
Molecular weight:
49298
Reactions
N(2)-succinyl-L-arginine + 2 H(2)O = N(2)-succinyl-L-ornithine + 2 NH(3) + CO(2).
General function:
Involved in D-cysteine desulfhydrase activity
Specific function:
Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine. Can also catalyze the degradation of 3-chloro-D-alanine
Gene Name:
dcyD
Uniprot ID:
P76316
Molecular weight:
35153
Reactions
D-cysteine + H(2)O = H(2)S + NH(3) + pyruvate.
General function:
Involved in hydrolase activity
Specific function:
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia
Gene Name:
guaD
Uniprot ID:
P76641
Molecular weight:
50244
Reactions
Guanine + H(2)O = xanthine + NH(3).
General function:
Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Specific function:
Involved in the anaerobic utilization of allantoin. Converts allantoate to (S)-ureidoglycolate and ammonia
Gene Name:
allC
Uniprot ID:
P77425
Molecular weight:
45694
General function:
Involved in metabolic process
Specific function:
Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo
Gene Name:
sufS
Uniprot ID:
P77444
Molecular weight:
44433
Reactions
L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.
L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor.
General function:
Involved in glutaminase activity
Specific function:
L-glutamine + H(2)O = L-glutamate + NH(3)
Gene Name:
glsA1
Uniprot ID:
P77454
Molecular weight:
32903
Reactions
L-glutamine + H(2)O = L-glutamate + NH(3).
General function:
Involved in cellular amino acid biosynthetic process
Specific function:
Specific function unknown
Gene Name:
yahI
Uniprot ID:
P77624
Molecular weight:
33931
General function:
Involved in ureidoglycolate hydrolase activity
Specific function:
Involved in the anaerobic utilization of allantoin. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate
Gene Name:
allA
Uniprot ID:
P77731
Molecular weight:
18169
Reactions
(S)-ureidoglycolate + H(2)O = glyoxylate + 2 NH(3) + CO(2).
General function:
Involved in cellular amino acid biosynthetic process
Specific function:
Specific function unknown
Gene Name:
yqeA
Uniprot ID:
Q46807
Molecular weight:
33071
General function:
Involved in FMN binding
Specific function:
Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase
Gene Name:
fldA
Uniprot ID:
P61949
Molecular weight:
19737
General function:
Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Specific function:
Makes part of the rut operon, which is required for the utilization of pyrimidines as sole nitrogen source
Gene Name:
rutB
Uniprot ID:
P75897
Molecular weight:
25209
Reactions
(Z)-3-ureidoacrylate peracid + H(2)O = (Z)-3-peroxyaminoacrylate + NH(3).
(Z)-3-ureidoacrylate + H(2)O = (Z)-3-aminoacrylate + CO(2) + NH(3).
(Z)-2-methyl-ureidoacrylate peracid + H(2)O = (Z)-2-methyl-peroxyaminoacrylate + CO(2) + NH(3).
General function:
Involved in argininosuccinate synthase activity
Specific function:
Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Gene Name:
queC
Uniprot ID:
P77756
Molecular weight:
25514
Reactions
7-carboxy-7-carbaguanine + NH(3) + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H(2)O.
General function:
Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Specific function:
Makes part of the rut operon, which is required for the utilization of pyrimidines as sole nitrogen source
Gene Name:
rutD
Uniprot ID:
P75895
Molecular weight:
28898
Reactions
(Z)-3-aminoacrylate + H(2)O = malonate semialdehyde + NH(3).
General function:
Amino acid transport and metabolism
Specific function:
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein
Gene Name:
gcvH
Uniprot ID:
P0A6T9
Molecular weight:
13811
General function:
Coenzyme transport and metabolism
Specific function:
Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)
Gene Name:
pdxH
Uniprot ID:
P0AFI7
Molecular weight:
25545
Reactions
Pyridoxamine 5'-phosphate + H(2)O + O(2) = pyridoxal 5'-phosphate + NH(3) + H(2)O(2).
Pyridoxine 5'-phosphate + O(2) = pyridoxal 5'-phosphate + H(2)O(2).
General function:
Not Available
Specific function:
Not Available
Gene Name:
eutA
Uniprot ID:
P76551
Molecular weight:
Not Available
General function:
Not Available
Specific function:
Not Available
Gene Name:
cobB
Uniprot ID:
P75960
Molecular weight:
Not Available
General function:
Not Available
Specific function:
Not Available
Gene Name:
yeaW
Uniprot ID:
P0ABR7
Molecular weight:
Not Available
General function:
Not Available
Specific function:
Not Available
Gene Name:
ylbA
Uniprot ID:
P75713
Molecular weight:
Not Available
General function:
Not Available
Specific function:
Not Available
Gene Name:
nrfE
Uniprot ID:
P32710
Molecular weight:
Not Available
General function:
Not Available
Specific function:
Not Available
Gene Name:
queE
Uniprot ID:
P64554
Molecular weight:
Not Available
General function:
Translation, ribosomal structure and biogenesis
Specific function:
May have a phosphotransferase activity
Gene Name:
yjgF
Uniprot ID:
P0AF93
Molecular weight:
13612
Reactions
Iminobutyrate + H(2)O = 2-oxobutanoate + NH(3).
General function:
Energy production and conversion
Specific function:
Deaminates adenosine-34 to inosine in tRNA-Arg2. Mutation in this protein makes E.coli resistant to the toxic proteins encoded by the gef gene family. Essential for cell viability
Gene Name:
tadA
Uniprot ID:
P68398
Molecular weight:
18717
Reactions
Adenosine + H(2)O = inosine + NH(3).
General function:
pyridine nucleotide biosynthetic process
Specific function:
Has nicotinamidemononucleotide (NMN) aminohydrolase activity, not active on other substrates.
Gene Name:
pncC
Uniprot ID:
P0A6G3
Molecular weight:
17581
Reactions
Beta-nicotinamide D-ribonucleotide + H(2)O = beta-nicotinate D-ribonucleotide + NH(3)

Transporters

General function:
Involved in ammonium transmembrane transporter activity
Specific function:
Involved in the uptake of ammonia
Gene Name:
amtB
Uniprot ID:
P69681
Molecular weight:
44514